{"id":"https://openalex.org/W2033606333","doi":"https://doi.org/10.1053/j.ajkd.2010.06.006","title":"The Role of Endothelial Cell Injury in Thrombotic Microangiopathy","display_name":"The Role of Endothelial Cell Injury in Thrombotic Microangiopathy","publication_year":2010,"publication_date":"2010-09-17","ids":{"openalex":"https://openalex.org/W2033606333","doi":"https://doi.org/10.1053/j.ajkd.2010.06.006","mag":"2033606333","pmid":"https://pubmed.ncbi.nlm.nih.gov/20843591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148799"},"language":"en","primary_location":{"id":"doi:10.1053/j.ajkd.2010.06.006","doi":"https://doi.org/10.1053/j.ajkd.2010.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.ajkd.2010.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S18197459","display_name":"American Journal of Kidney Diseases","issn_l":"0272-6386","issn":["0272-6386","1523-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Kidney Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148799","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029995920","display_name":"Ryan J. Goldberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan J. Goldberg","raw_affiliation_strings":["Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA. rygoldberg@sbhcs.com","Division of Renal Diseases & Hypertension, University of Colorado Denver, Aurora, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA. rygoldberg@sbhcs.com","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Division of Renal Diseases & Hypertension, University of Colorado Denver, Aurora, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043202842","display_name":"Takahiko Nakagawa","orcid":"https://orcid.org/0000-0002-0127-1529","observed_orcids":["https://orcid.org/0000-0002-0127-1529"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takahiko Nakagawa","raw_affiliation_strings":["Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004471228","display_name":"Richard J. Johnson","orcid":"https://orcid.org/0000-0003-3312-8193","observed_orcids":["https://orcid.org/0000-0003-3312-8193"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Johnson","raw_affiliation_strings":["Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069245735","display_name":"Joshua M. Thurman","orcid":"https://orcid.org/0000-0002-3476-9956","observed_orcids":["https://orcid.org/0000-0002-3476-9956","https://orcid.org/0000-0001-9062-3559"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua M. Thurman","raw_affiliation_strings":["Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029995920"],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":2.3133,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.88143123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"56","issue":"6","first_page":"1168","last_page":"1174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8759999871253967},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide","display_name":"endothelial nitric oxide","score":0.8820000290870667},{"id":"https://openalex.org/keywords/microangiopathic-hemolytic-anemia","display_name":"microangiopathic hemolytic anemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.9290000200271606},{"id":"https://openalex.org/keywords/von-willebrand-factor-cleavage","display_name":"von Willebrand factor cleavage","score":0.8240000009536743},{"id":"https://openalex.org/keywords/endothelial-protection","display_name":"endothelial protection","score":0.5339999794960022},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9909999966621399},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.8510000109672546},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.8882580995559692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.870592474937439},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.7304275035858154},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6296725273132324},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.62659752368927},{"id":"https://openalex.org/C2776513394","wikidata":"https://www.wikidata.org/wiki/Q1412400","display_name":"Microangiopathy","level":3,"score":0.5429023504257202},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.44462576508522034},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4322143495082855},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41435515880584717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2765401601791382},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18394264578819275},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.09234067797660828},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07750916481018066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0625753104686737},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006463","descriptor_name":"Hemolytic-Uremic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006463","descriptor_name":"Hemolytic-Uremic Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010951","descriptor_name":"Plasma Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D065766","descriptor_name":"Atypical Hemolytic Uremic Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1053/j.ajkd.2010.06.006","doi":"https://doi.org/10.1053/j.ajkd.2010.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.ajkd.2010.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S18197459","display_name":"American Journal of Kidney Diseases","issn_l":"0272-6386","issn":["0272-6386","1523-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Kidney Diseases","raw_type":"journal-article"},{"id":"pmid:20843591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20843591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of kidney diseases : the official journal of the National Kidney Foundation","raw_type":"Case Reports"},{"id":"pmh:oai:europepmc.org:2156744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3148799","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3148799/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Kidney Dis","raw_type":"Text"},{"id":"mag:2779626913","doi":null,"is_oa":false,"landing_page_url":"https://www.ajkd.org/article/S0272-6386(10)01039-5/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2156744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7681360128","display_name":"Endothelial Cell in Progressive Renal Disease","funder_award_id":"R01DK052121","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000857006","display_name":"Complement-mediated injury of the kidney: New mechanisms and novel therapies","funder_award_id":"R01DK076690","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W179239628","https://openalex.org/W1870404453","https://openalex.org/W1917101340","https://openalex.org/W1970913092","https://openalex.org/W1983289139","https://openalex.org/W1986088447","https://openalex.org/W1988334706","https://openalex.org/W1989797372","https://openalex.org/W1997746165","https://openalex.org/W2001592623","https://openalex.org/W2008198181","https://openalex.org/W2008607429","https://openalex.org/W2009708858","https://openalex.org/W2011784685","https://openalex.org/W2012542707","https://openalex.org/W2015046929","https://openalex.org/W2023724259","https://openalex.org/W2028031291","https://openalex.org/W2029132172","https://openalex.org/W2032218413","https://openalex.org/W2039660350","https://openalex.org/W2045488836","https://openalex.org/W2049316656","https://openalex.org/W2051608653","https://openalex.org/W2054729118","https://openalex.org/W2056922312","https://openalex.org/W2064910821","https://openalex.org/W2064985699","https://openalex.org/W2066911756","https://openalex.org/W2078299561","https://openalex.org/W2081518693","https://openalex.org/W2084467546","https://openalex.org/W2085728170","https://openalex.org/W2086962838","https://openalex.org/W2093441969","https://openalex.org/W2096735552","https://openalex.org/W2101391992","https://openalex.org/W2105632053","https://openalex.org/W2109460872","https://openalex.org/W2112791998","https://openalex.org/W2116977643","https://openalex.org/W2117019199","https://openalex.org/W2117310528","https://openalex.org/W2124342337","https://openalex.org/W2126092981","https://openalex.org/W2130928200","https://openalex.org/W2134111229","https://openalex.org/W2143180984","https://openalex.org/W2145630112","https://openalex.org/W2147978034","https://openalex.org/W2150027863","https://openalex.org/W2150893441","https://openalex.org/W2157039673","https://openalex.org/W2157991535","https://openalex.org/W2159442474","https://openalex.org/W2159584550","https://openalex.org/W2166421772","https://openalex.org/W2169190847","https://openalex.org/W2169673413","https://openalex.org/W2286057595","https://openalex.org/W2292060081","https://openalex.org/W2419546676","https://openalex.org/W2469405187","https://openalex.org/W4255377991","https://openalex.org/W4299438478"],"related_works":["https://openalex.org/W2779626913","https://openalex.org/W4224869638","https://openalex.org/W85840762","https://openalex.org/W4311138749","https://openalex.org/W3126835512","https://openalex.org/W4230901927","https://openalex.org/W2031360287","https://openalex.org/W4386084861","https://openalex.org/W2199334745","https://openalex.org/W2524643118"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}