{"id":"https://openalex.org/W2033598288","doi":"https://doi.org/10.1210/en.2005-0853","title":"Allelic Variation on Chromosome 5 Controls \u03b2-Cell Mass Expansion during Hyperglycemia in Leptin Receptor-Deficient Diabetes Mice","display_name":"Allelic Variation on Chromosome 5 Controls \u03b2-Cell Mass Expansion during Hyperglycemia in Leptin Receptor-Deficient Diabetes Mice","publication_year":2006,"publication_date":"2006-02-17","ids":{"openalex":"https://openalex.org/W2033598288","doi":"https://doi.org/10.1210/en.2005-0853","mag":"2033598288","pmid":"https://pubmed.ncbi.nlm.nih.gov/16484328"},"language":"en","primary_location":{"id":"doi:10.1210/en.2005-0853","doi":"https://doi.org/10.1210/en.2005-0853","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2005-0853","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100782144","display_name":"Na Luo","orcid":"https://orcid.org/0000-0003-4411-773X","observed_orcids":["https://orcid.org/0000-0003-4411-773X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Na Luo","raw_affiliation_strings":["Institute of Human Nutrition, Department of Pediatrics, Columbia University, New York, New York 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition, Department of Pediatrics, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110728595","display_name":"Shun-Mei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shun Mei Liu","raw_affiliation_strings":["Division of Endocrinology (S.M.L., S.C.), Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (S.M.L., S.C.), Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410371","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0003-3685-6268","observed_orcids":["https://orcid.org/0000-0003-3685-6268","https://orcid.org/0000-0002-7256-5751"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358443","display_name":"Qiong Li","orcid":"https://orcid.org/0000-0002-8915-8781","observed_orcids":["https://orcid.org/0000-0002-8915-8781"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiong Li","raw_affiliation_strings":["Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037838582","display_name":"Qun Xu","orcid":"https://orcid.org/0000-0003-0141-4427","observed_orcids":["https://orcid.org/0000-0003-0141-4427"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qun Xu","raw_affiliation_strings":["Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xi Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Sun","raw_affiliation_strings":["Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063971820","display_name":"Brandi Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi Davis","raw_affiliation_strings":["Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439965","display_name":"Jing Li","orcid":"https://orcid.org/0009-0008-1301-2533","observed_orcids":["https://orcid.org/0009-0008-1301-2533"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics (H.L., Q.L., Q.X., X.S., B.D., J.L.), Department of Pediatrics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066893639","display_name":"Streamson C. Chua","orcid":"https://orcid.org/0000-0002-9437-9925","observed_orcids":["https://orcid.org/0000-0002-9437-9925"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Streamson Chua","raw_affiliation_strings":["Division of Endocrinology (S.M.L., S.C.), Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (S.M.L., S.C.), Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066893639"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.9068,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7612696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"147","issue":"5","first_page":"2287","last_page":"2295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin-receptor-deficiency","display_name":"leptin receptor deficiency","score":0.8799999952316284},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.7590000033378601},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/beta-cell-mass-expansion","display_name":"beta-cell mass expansion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/chromosome-5","display_name":"chromosome 5","score":0.777999997138977},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.703000009059906},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6520000100135803},{"id":"https://openalex.org/keywords/congenic-strains","display_name":"congenic strains","score":0.7149999737739563},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fvb-mice","display_name":"FVB mice","score":0.48899999260902405},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.9649999737739563},{"id":"https://openalex.org/keywords/backcrossing","display_name":"backcrossing","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8476762771606445},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8397341966629028},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7087138891220093},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.6081114411354065},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5943705439567566},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5459638237953186},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5111568570137024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4628656804561615},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.4383406937122345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42077717185020447},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4111385941505432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2672906816005707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17427310347557068},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/en.2005-0853","doi":"https://doi.org/10.1210/en.2005-0853","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2005-0853","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:16484328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16484328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4188449624","display_name":"Leptin Receptor and the Obesity/Diabetes Syndrome","funder_award_id":"R01DK057621","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6604127207","display_name":"Genetic Modifiers of Diabetes","funder_award_id":"R01DK063306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G788956770","display_name":"Diabetes Research and Training Center","funder_award_id":"P60DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000867824","display_name":"New York Obesity Research Center","funder_award_id":"P30DK026687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868310","display_name":"Columbia Diabetes Research Center","funder_award_id":"P30DK063608","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W54560069","https://openalex.org/W1520222296","https://openalex.org/W1530654453","https://openalex.org/W1975591343","https://openalex.org/W1981387915","https://openalex.org/W1986991051","https://openalex.org/W1994892275","https://openalex.org/W1995338231","https://openalex.org/W1999179141","https://openalex.org/W2000511325","https://openalex.org/W2002646221","https://openalex.org/W2003264741","https://openalex.org/W2016979581","https://openalex.org/W2017735272","https://openalex.org/W2020053653","https://openalex.org/W2052481221","https://openalex.org/W2063966134","https://openalex.org/W2064681938","https://openalex.org/W2079075339","https://openalex.org/W2098915229","https://openalex.org/W2107471483","https://openalex.org/W2117642801","https://openalex.org/W2122998674","https://openalex.org/W2126255897","https://openalex.org/W2127741441","https://openalex.org/W2144803025","https://openalex.org/W2149364745","https://openalex.org/W2150793125","https://openalex.org/W2154652388","https://openalex.org/W2155666326","https://openalex.org/W2161381121","https://openalex.org/W2162560823","https://openalex.org/W2163285329","https://openalex.org/W2169206971","https://openalex.org/W2326319116"],"related_works":["https://openalex.org/W2063966134","https://openalex.org/W1979403492","https://openalex.org/W2161003704","https://openalex.org/W2118631685","https://openalex.org/W192617961","https://openalex.org/W2319535267","https://openalex.org/W2090113277","https://openalex.org/W1993445904","https://openalex.org/W1555779060","https://openalex.org/W2166767145"],"abstract_inverted_index":{"Leptin":[0],"signaling":[1,24],"is":[2,129,147,165,185],"a":[3],"critical":[4],"component":[5],"of":[6,22,30,45,84,110,134,152,157,180,192],"normal":[7],"insulin":[8,40,57,70,97,172],"sensitivity.":[9],"Overt":[10],"hyperglycemia":[11,141,153],"and":[12,42,59,72,170],"type":[13],"2":[14],"diabetes":[15,48],"mellitus":[16],"can":[17],"be":[18],"manifested":[19],"in":[20,143,154],"states":[21,44],"leptin":[23],"deficiencies":[25],"by":[26,131],"the":[27,38,88,111,132,140,160,190],"additional":[28],"effects":[29],"other":[31],"genetic":[32,94],"factors.":[33],"We":[34],"have":[35,55,68],"previously":[36],"described":[37],"contrasting":[39],"sensitivities":[41],"glycemic":[43],"two":[46,89],"congenic":[47,137,183,194],"(db/db)":[49],"mouse":[50],"strains.":[51,195],"C57BL/6J":[52],"db/db":[53,66],"mice":[54,67,146,156],"mild":[56,63],"resistance":[58,71],"achieve":[60],"euglycemia":[61],"with":[62,78,167],"hyperinsulinemia.":[64],"FVB":[65,114,145],"severe":[69],"are":[73,99,122],"hyperglycemic":[74],"despite":[75],"escalating":[76],"hyperinsulinemia":[77],"expanded":[79],"pancreatic":[80],"beta-cell":[81,105,168],"mass.":[82,106],"Analysis":[83],"obese":[85,144,155],"progeny":[86],"from":[87,101],"reciprocal":[90],"backcrosses":[91],"suggests":[92,115],"that":[93,103,116,178],"modifiers":[95],"for":[96],"sensitivity":[98],"separable":[100],"loci":[102],"modulate":[104],"A":[107],"genome":[108],"scan":[109],"backcross":[112],"to":[113,189],"one":[117],"or":[118],"more":[119],"modifier":[120],"genes":[121],"present":[123],"on":[124],"chromosome":[125,163],"5.":[126],"This":[127],"evidence":[128],"supported":[130],"phenotypes":[133],"multiple":[135,181],"incipient":[136,182],"strains":[138],"wherein":[139],"observed":[142],"reproduced.":[148],"With":[149],"similar":[150],"degrees":[151],"these":[158],"strains,":[159],"haplotype":[161],"at":[162],"5":[164],"associated":[166],"mass":[169],"circulating":[171],"concentrations.":[173],"Finally,":[174],"we":[175],"offer":[176],"arguments":[177],"production":[179,191],"lines":[184],"an":[186],"economical":[187],"alternative":[188],"speed":[193]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
