{"id":"https://openalex.org/W2033570261","doi":"https://doi.org/10.1016/j.neurobiolaging.2012.01.032","title":"14 Inhibition of glutaminyl cyclase targeting neurodegeneration and neuroinflammation in Alzheimer's disease","display_name":"14 Inhibition of glutaminyl cyclase targeting neurodegeneration and neuroinflammation in Alzheimer's disease","publication_year":2012,"publication_date":"2012-04-04","ids":{"openalex":"https://openalex.org/W2033570261","doi":"https://doi.org/10.1016/j.neurobiolaging.2012.01.032","mag":"2033570261"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurobiolaging.2012.01.032","doi":"https://doi.org/10.1016/j.neurobiolaging.2012.01.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2012.01.032","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102711941","display_name":"Hans\u2010Ulrich Demuth","orcid":"https://orcid.org/0000-0003-3505-6795","observed_orcids":["https://orcid.org/0000-0003-3505-6795"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans-Ulrich Demuth","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101728684","display_name":"Stephan Schilling","orcid":"https://orcid.org/0000-0002-0233-4763","observed_orcids":["https://orcid.org/0000-0002-0233-4763"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Schilling","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064065407","display_name":"Holger Cynis","orcid":"https://orcid.org/0000-0001-6655-7539","observed_orcids":["https://orcid.org/0000-0001-6655-7539"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Cynis","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040602339","display_name":"Ulrich F. Heiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Heiser","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040786000","display_name":"Susanne Manhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Manhart","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000192634","display_name":"Sigrid Graubner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099772","display_name":"Ingenium (Germany)","ror":"https://ror.org/00wvsjr52","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099772"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Graubner","raw_affiliation_strings":["Ingenium GmbH, Munich-Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ingenium GmbH, Munich-Martinsried, Germany","institution_ids":["https://openalex.org/I4210099772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066384320","display_name":"Anca Alexandru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099772","display_name":"Ingenium (Germany)","ror":"https://ror.org/00wvsjr52","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099772"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Alexandru","raw_affiliation_strings":["Ingenium GmbH, Munich-Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ingenium GmbH, Munich-Martinsried, Germany","institution_ids":["https://openalex.org/I4210099772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034364271","display_name":"Wolfgang Jagla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099772","display_name":"Ingenium (Germany)","ror":"https://ror.org/00wvsjr52","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099772"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Jagla","raw_affiliation_strings":["Ingenium GmbH, Munich-Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ingenium GmbH, Munich-Martinsried, Germany","institution_ids":["https://openalex.org/I4210099772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111615153","display_name":"Ingeborg Lues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Lues","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F. Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Weber","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111849781","display_name":"K. Glund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Glund","raw_affiliation_strings":["Probiodrug AG, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102711941"],"corresponding_institution_ids":["https://openalex.org/I4210144058"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"S7","last_page":"S7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9391233921051025},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.9236229658126831},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5139963030815125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5095968246459961},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4203595519065857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39877381920814514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16451475024223328},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10627654194831848}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.neurobiolaging.2012.01.032","doi":"https://doi.org/10.1016/j.neurobiolaging.2012.01.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2012.01.032","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7132355528","https://openalex.org/W7132342648","https://openalex.org/W6982536759","https://openalex.org/W4252340991","https://openalex.org/W2044269554","https://openalex.org/W2028637164","https://openalex.org/W2105072974","https://openalex.org/W1992808511","https://openalex.org/W4234980028","https://openalex.org/W2144144797"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}