{"id":"https://openalex.org/W2033560699","doi":"https://doi.org/10.1530/jrf.0.0690523","title":"Influence of complement depletion on sperm function in the female rabbit","display_name":"Influence of complement depletion on sperm function in the female rabbit","publication_year":1983,"publication_date":"1983-11-01","ids":{"openalex":"https://openalex.org/W2033560699","doi":"https://doi.org/10.1530/jrf.0.0690523","mag":"2033560699","pmid":"https://pubmed.ncbi.nlm.nih.gov/6631819"},"language":"en","primary_location":{"id":"doi:10.1530/jrf.0.0690523","doi":"https://doi.org/10.1530/jrf.0.0690523","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0690523","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/69/2/jrf_69_2_016.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/69/2/jrf_69_2_016.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111946405","display_name":"J. MICHAEL BEDFORD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Bedford","raw_affiliation_strings":["Departments of*Obstetrics and Gynaecology and \\Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Obstetrics and Gynaecology and \\Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, U.S.A","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055608441","display_name":"Steven Sol Witkin","orcid":"https://orcid.org/0000-0002-3502-3929","observed_orcids":["https://orcid.org/0000-0002-3502-3929"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Witkin","raw_affiliation_strings":["Departments of*Obstetrics and Gynaecology and \\Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Obstetrics and Gynaecology and \\Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, U.S.A","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":0.8492,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68124554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"2","first_page":"523","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-depletion","display_name":"complement depletion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sperm-function","display_name":"sperm function","score":0.7099999785423279},{"id":"https://openalex.org/keywords/acrosome-reaction","display_name":"acrosome reaction","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cobra-venom-factor","display_name":"cobra venom factor","score":0.7350000143051147},{"id":"https://openalex.org/keywords/female-rabbits","display_name":"female rabbits","score":0.49799999594688416},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.49399998784065247},{"id":"https://openalex.org/keywords/sperm-egg-interaction","display_name":"sperm-egg interaction","score":0.48500001430511475},{"id":"https://openalex.org/keywords/vaginal-insemination","display_name":"vaginal insemination","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6824317574501038},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.6706805229187012},{"id":"https://openalex.org/C2779995066","wikidata":"https://www.wikidata.org/wiki/Q163261","display_name":"Acrosome reaction","level":3,"score":0.5874689221382141},{"id":"https://openalex.org/C2777005246","wikidata":"https://www.wikidata.org/wiki/Q1379223","display_name":"Insemination","level":3,"score":0.574289858341217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5242969393730164},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.520347535610199},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.49362075328826904},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.4867089092731476},{"id":"https://openalex.org/C2778252442","wikidata":"https://www.wikidata.org/wiki/Q421111","display_name":"Acrosome","level":3,"score":0.41147294640541077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30596235394477844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2720855474472046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19441741704940796},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1817193627357483}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005306","descriptor_name":"Fertilization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013083","descriptor_name":"Sperm Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013084","descriptor_name":"Sperm-Ovum Interactions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/jrf.0.0690523","doi":"https://doi.org/10.1530/jrf.0.0690523","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0690523","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/69/2/jrf_69_2_016.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:6631819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6631819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of reproduction and fertility","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1530/jrf.0.0690523","doi":"https://doi.org/10.1530/jrf.0.0690523","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0690523","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/69/2/jrf_69_2_016.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033560699.pdf","grobid_xml":"https://content.openalex.org/works/W2033560699.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W66712894","https://openalex.org/W1419032123","https://openalex.org/W1493618746","https://openalex.org/W1511796519","https://openalex.org/W1988122177","https://openalex.org/W2004060764","https://openalex.org/W2011199011","https://openalex.org/W2014991861","https://openalex.org/W2036501071","https://openalex.org/W2049200105","https://openalex.org/W2051466847","https://openalex.org/W2051877934","https://openalex.org/W2068979554","https://openalex.org/W2082443992","https://openalex.org/W2093223700","https://openalex.org/W2095688796","https://openalex.org/W2116591857","https://openalex.org/W2124400594","https://openalex.org/W2151619719","https://openalex.org/W2157598670","https://openalex.org/W2288368577","https://openalex.org/W2300792535","https://openalex.org/W2410476973","https://openalex.org/W2414957766"],"related_works":["https://openalex.org/W2051466847","https://openalex.org/W2068979554","https://openalex.org/W7097963519","https://openalex.org/W2157598670","https://openalex.org/W2093223700","https://openalex.org/W2008069172","https://openalex.org/W2097740324","https://openalex.org/W2032723100","https://openalex.org/W2055611387","https://openalex.org/W2410476973"],"abstract_inverted_index":{"Female":[0],"rabbits":[1],"were":[2,55],"wholly":[3],"depleted":[4],"of":[5,25,34,102],"complement":[6,88],"by":[7,31],"treatment":[8],"with":[9],"anti-complementary":[10],"cobra":[11],"venom":[12],"factor":[13],"(CVF)":[14],"36":[15],"h":[16,38],"before":[17],"mating.":[18],"Complement":[19],"depletion":[20],"did":[21],"not":[22],"compromise":[23],"occurrence":[24],"the":[26,50,60,64,72,80,103],"acrosome":[27,81],"reaction,":[28],"as":[29],"judged":[30],"sperm":[32],"penetration":[33],"eggs":[35],"collected":[36],"12-13":[37],"post":[39],"coitum.":[40],"However,":[41],"in":[42,57,67],"CVF-treated":[43],"females,":[44],"significantly":[45],"more":[46,53],"spermatozoa":[47,54,98],"had":[48],"penetrated":[49],"egg":[51],"vestments,":[52],"present":[56],"flushings":[58],"from":[59],"oviducts,":[61],"and":[62],"sometimes":[63],"uterus,":[65],"than":[66],"control":[68],"females":[69],"mated":[70],"to":[71,85],"same":[73],"males.":[74],"The":[75],"results":[76],"indicate":[77],"that,":[78],"although":[79],"reaction":[82],"is":[83],"unlikely":[84],"depend":[86],"on":[87,97],"activation,":[89],"complement-dependent":[90],"factors":[91],"may":[92],"exert":[93],"a":[94],"restrictive":[95],"effect":[96],"after":[99],"vaginal":[100],"insemination":[101],"normal":[104],"female":[105],"rabbit.":[106]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}