{"id":"https://openalex.org/W2033515535","doi":"https://doi.org/10.1158/1538-7445.am2011-2282","title":"Abstract 2282: The K303R estrogen receptor \u03b1 mutation and hormone resistance in breast cancer","display_name":"Abstract 2282: The K303R estrogen receptor \u03b1 mutation and hormone resistance in breast cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2033515535","doi":"https://doi.org/10.1158/1538-7445.am2011-2282","mag":"2033515535"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-2282","doi":"https://doi.org/10.1158/1538-7445.am2011-2282","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2282","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Guowei Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guowei Gu","raw_affiliation_strings":["1Baylor College of Medicine, Houston, TX","#N#1Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"#N#1Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103722195","display_name":"Weiyan Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiyan Cai","raw_affiliation_strings":["1Baylor College of Medicine, Houston, TX","#N#1Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"#N#1Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004954310","display_name":"Katherine Stemke\u2010Hale","orcid":"https://orcid.org/0000-0002-1231-4192","observed_orcids":["https://orcid.org/0000-0002-1231-4192"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Stemke Hale","raw_affiliation_strings":["2MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":["2MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102010816","display_name":"Sebastiano And\u00f2","orcid":"https://orcid.org/0000-0002-5412-7045","observed_orcids":["https://orcid.org/0000-0002-5412-7045"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sebastiano Ando'","raw_affiliation_strings":["3Centro Sanitario, University of Calabria, Cosenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Centro Sanitario, University of Calabria, Cosenza, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054255756","display_name":"Suzanne A.W. Fuqua","orcid":"https://orcid.org/0000-0001-8886-5161","observed_orcids":["https://orcid.org/0000-0001-8886-5161"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne A.W. Fuqua","raw_affiliation_strings":["1Baylor College of Medicine, Houston, TX","#N#1Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"#N#1Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"2282","last_page":"2282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7940000295639038},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tamoxifen-resistance","display_name":"tamoxifen resistance","score":0.8920000195503235},{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/anastrozole","display_name":"anastrozole","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pik3ca-e545k-mutation","display_name":"PIK3CA E545K mutation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/akt1-e17k-mutation","display_name":"AKT1 E17K mutation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/growth-factor-receptor-signaling","display_name":"growth factor receptor signaling","score":0.6290000081062317},{"id":"https://openalex.org/keywords/adjuvant-tamoxifen","display_name":"adjuvant tamoxifen","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7580910921096802},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.6991147994995117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6142109632492065},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5898319482803345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5547241568565369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5143519639968872},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47241607308387756},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4535178244113922},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.38855302333831787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3259294033050537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24442800879478455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12674367427825928},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-2282","doi":"https://doi.org/10.1158/1538-7445.am2011-2282","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2282","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018053964","https://openalex.org/W1971737318","https://openalex.org/W1965012758","https://openalex.org/W2121409164","https://openalex.org/W7098140710","https://openalex.org/W1606675799","https://openalex.org/W2120052914","https://openalex.org/W2102726822","https://openalex.org/W1607418737","https://openalex.org/W4299944323"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"We":[2,46,100,197,242,337],"have":[3,390],"previously":[4],"identified":[5],"a":[6,28,292,309],"A":[7,180,296],"to":[8,30,44,56,107,186,206,212,229,361],"G":[9],"somatic":[10],"mutation":[11,25,52,87,110,261,302,329,342,353],"at":[12,33,291,303],"nucleotide":[13],"908":[14],"of":[15,83,92,123,139,172,216,236,258,286,312,320,325,349,368,384,415,420],"ER\u03b1":[16,51,86,227,260,352],"(A908G)":[17],"in":[18,27,37,69,111,126,210,251,271,282,305,354],"premalignant":[19],"and":[20,61,98,129,131,134,150,170,240,332,398],"invasive":[21],"breast":[22,113,154,247,273,404],"cancers.":[23],"This":[24],"results":[26,189],"lysine":[29],"arginine":[31],"transition":[32],"residue":[34],"303":[35],"(K303R)":[36],"the":[38,49,57,84,95,109,137,173,201,214,217,226,237,259,265,283,300,317,326,340,347,350,379,416,421],"hinge":[39],"domain":[40,285],"which":[41,280],"confers":[42,54],"hypersensitivity":[43],"estrogen.":[45],"discovered":[47],"that":[48,339],"K303R":[50,85,351],"also":[53,200,289],"resistance":[55],"aromatase":[58],"inhibitor":[59],"anastrazole":[60],"blocks":[62],"tamoxifen's":[63],"(Tam)":[64],"antagonist":[65],"action":[66],"when":[67],"engaged":[68],"crosstalk":[70],"with":[71,81,117,121,142,152,157,164,233,346,371],"growth":[72],"factor":[73],"receptor":[74],"signaling":[75],"pathways.":[76],"The":[77,256,276,323],"resistant":[78],"phenotype":[79],"associated":[80,345],"expression":[82],"is":[88,184],"dependent":[89],"on":[90],"activation":[91],"phospho-S305":[93,228],"within":[94],"receptor.":[96],"Aims":[97],"Methods:":[99],"are":[101,359,366],"currently":[102],"using":[103,190],"mass":[104],"spectroscopy":[105],"(sequenom)":[106],"detect":[108],"204":[112],"cancer":[114,274,405],"patients":[115,397],"treated":[116,156,396],"monotherapy":[118,178],"Tam,":[119],"along":[120],"detection":[122],"specific":[124],"mutations":[125,141,209,365,386],"PIK3CA":[127,277,327,341],"(E545K":[128],"H1047R/L)":[130],"AKT1":[132,333],"(E17K),":[133],"will":[135,198,222,377],"correlate":[136],"presence":[138,348],"these":[140,188,208,364,382],"clinical":[143,392],"outcomes.":[144],"Patients":[145],"were":[146],"diagnosed":[147],"between":[148],"1973":[149],"1993":[151],"primary":[153],"cancer,":[155],"mastectomy":[158],"or":[159,165,387],"lumpectomy":[160],"plus":[161],"axillary":[162],"dissestion,":[163],"without":[166],"post-operative":[167],"radiation":[168],"therapy,":[169],"all":[171],"women":[174],"underwent":[175],"adjuvant":[176],"tamoxifen":[177],"treatment.":[179,406],"larger":[181],"validation":[182],"study":[183],"ongoing":[185,360],"confirm":[187,207],"DNA":[191,244,306],"samples":[192,249,307],"from":[193,245,308],"500":[194],"Tam-treated":[195,355],"patients.":[196,238,275,356],"use":[199],"ABI":[202],"3730XL":[203],"SNAPSHOT":[204],"machine":[205],"order":[211],"compare":[213],"sensitivity":[215],"two":[218],"techniques.":[219],"Immunohistochemistry":[220],"staining":[221],"be":[223],"developed":[224],"for":[225,394,403,424],"further":[230],"evaluate":[231],"correlations":[232],"clicnical":[234],"outcome":[235,370],"Results":[239],"Conclusion:":[241],"sequenced":[243],"n=204":[246],"tumor":[248,310],"archived":[250],"formalin-fixed,":[252],"paraffin-embedded":[253],"tissue":[254],"microarrays.":[255],"frequency":[257,267,294,319],"was":[262,288,330,335,343],"57%,":[263],"replicating":[264],"high":[266,293],"we":[268],"previousl":[269],"reported":[270,299],"untreated":[272],"A3140G/T":[278,301],"mutation,":[279],"occurs":[281],"catalytic":[284],"PIK3CA,":[287],"found":[290,338],"(19%).":[295],"previous":[297],"publication":[298],"13%":[304,331],"bank":[311],"547":[313],"patients,":[314],"thus":[315],"confirming":[316],"relative":[318],"this":[321],"mutation.":[322],"percentage":[324],"G1633A":[328],"G49A":[334],"3.4%.":[336],"significantly":[344],"Survival":[357],"analyses":[358],"determine":[362],"if":[363],"predictive":[367],"treatment":[369],"Tam.":[372],"In":[373],"summary,":[374],"our":[375],"finding":[376],"answer":[378],"question":[380],"whether":[381],"gain":[383],"function":[385],"combination":[388],"might":[389],"worse":[391],"outcomes":[393],"Tam":[395],"establish":[399],"new":[400],"prognostic":[401],"markers":[402],"Citation":[407],"Format:":[408],"{Authors}.":[409],"{Abstract":[410],"title}":[411],"[abstract].":[412],"In:":[413],"Proceedings":[414],"102nd":[417],"Annual":[418],"Meeting":[419],"American":[422],"Association":[423],"Cancer":[425,435],"Research;":[426],"2011":[427],"Apr":[428],"2-6;":[429],"Orlando,":[430],"FL.":[431],"Philadelphia":[432],"(PA):":[433],"AACR;":[434],"Res":[436],"2011;71(8":[437],"Suppl):Abstract":[438],"nr":[439],"2282.":[440],"doi:10.1158/1538-7445.AM2011-2282":[441]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}