{"id":"https://openalex.org/W2033490663","doi":"https://doi.org/10.1111/j.1365-2184.1979.tb00166.x","title":"THYMUS DERIVED INHIBITOR OF LYMPHOCYTE PROLIFERATION I. ISOLATION AND ASSESSMENT OF TISSUE SPECIFICITY","display_name":"THYMUS DERIVED INHIBITOR OF LYMPHOCYTE PROLIFERATION I. ISOLATION AND ASSESSMENT OF TISSUE SPECIFICITY","publication_year":1979,"publication_date":"1979-07-01","ids":{"openalex":"https://openalex.org/W2033490663","doi":"https://doi.org/10.1111/j.1365-2184.1979.tb00166.x","mag":"2033490663","pmid":"https://pubmed.ncbi.nlm.nih.gov/314336"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2184.1979.tb00166.x","doi":"https://doi.org/10.1111/j.1365-2184.1979.tb00166.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2184.1979.tb00166.x","pdf_url":null,"source":{"id":"https://openalex.org/S86484535","display_name":"Cell Proliferation","issn_l":"0960-7722","issn":["0960-7722","1365-2184"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Proliferation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021011649","display_name":"E. Rijke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"E. O. Rijke","raw_affiliation_strings":["Department of Clinical Immunology, University Hospital, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, University Hospital, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109901607","display_name":"RUDY E. BALLIEUX","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. E. Ballieux","raw_affiliation_strings":["Department of Clinical Immunology, University Hospital, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, University Hospital, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021011649"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":0.7168,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.66666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"4","first_page":"435","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphocyte-proliferation-inhibition","display_name":"lymphocyte proliferation inhibition","score":0.9070000052452087},{"id":"https://openalex.org/keywords/thymus-extract","display_name":"thymus extract","score":0.6919999718666077},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.8230000138282776},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tissue-specificity","display_name":"tissue specificity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bovine-thymus","display_name":"bovine thymus","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dose-dependent-inhibition","display_name":"dose-dependent inhibition","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6844050884246826},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.653264045715332},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6285726428031921},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.6127367615699768},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.6005260944366455},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5732347369194031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5344347953796387},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4977095425128937},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4889758825302124},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4749997854232788},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4143187999725342},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38169142603874207},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3665022850036621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3212314248085022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21438607573509216},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10748043656349182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013949","descriptor_name":"Thymus Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2184.1979.tb00166.x","doi":"https://doi.org/10.1111/j.1365-2184.1979.tb00166.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2184.1979.tb00166.x","pdf_url":null,"source":{"id":"https://openalex.org/S86484535","display_name":"Cell Proliferation","issn_l":"0960-7722","issn":["0960-7722","1365-2184"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Proliferation","raw_type":"journal-article"},{"id":"pmid:314336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/314336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and tissue kinetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W30676514","https://openalex.org/W1490731433","https://openalex.org/W1556561888","https://openalex.org/W1965849296","https://openalex.org/W1968005192","https://openalex.org/W1977646157","https://openalex.org/W1977904979","https://openalex.org/W1990126094","https://openalex.org/W2006726310","https://openalex.org/W2022181875","https://openalex.org/W2029447387","https://openalex.org/W2045317574","https://openalex.org/W2057264099","https://openalex.org/W2085948243","https://openalex.org/W2087342348","https://openalex.org/W2093431264","https://openalex.org/W2414494063","https://openalex.org/W2434881119","https://openalex.org/W2468119228","https://openalex.org/W4254542218"],"related_works":["https://openalex.org/W1515344289","https://openalex.org/W2093431264","https://openalex.org/W2019047701","https://openalex.org/W194646155","https://openalex.org/W1992438900","https://openalex.org/W2046961945","https://openalex.org/W2002325234","https://openalex.org/W2415490812","https://openalex.org/W2399923968","https://openalex.org/W2395025587"],"abstract_inverted_index":{"Preparations":[0],"from":[1,76],"bovine":[2,77],"thymus":[3],"tissue":[4],"were":[5],"analyzed":[6],"for":[7,71],"their":[8],"inhibitory":[9,67],"effects":[10],"during":[11],"in":[12,26,86],"vitro":[13],"lymphocyte":[14],"proliferation.":[15],"The":[16],"results":[17],"indicate":[18],"that":[19,65],"these":[20],"preparations":[21,75],"strongly":[22],"inhibit":[23],"DNA":[24],"synthesis":[25],"stimulated":[27],"human":[28,62],"peripheral":[29],"lymphocytes,":[30],"bone":[31],"marrow":[32],"cells,":[33],"thymocytes":[34],"and":[35,42,61],"lymphoblastoid":[36],"cells.":[37],"This":[38],"inhibition":[39,51],"was":[40,52,69],"dose-dependent":[41],"not":[43,82],"due":[44],"to":[45],"cytotoxicity":[46],"of":[47,54,58],"the":[48,55,66,87],"preparations.":[49],"No":[50],"found":[53],"spontaneous":[56],"proliferation":[57],"HeLa":[59],"cells":[60],"fibroblasts":[63],"indicating":[64],"effect":[68],"specific":[70],"proliferating":[72],"lymphocytes.":[73],"Control":[74],"liver":[78],"or":[79],"kidney":[80],"did":[81],"show":[83],"any":[84],"suppression":[85],"test":[88],"systems":[89],"used.":[90]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}