{"id":"https://openalex.org/W2033471108","doi":"https://doi.org/10.1074/jbc.m706494200","title":"Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line","display_name":"Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line","publication_year":2008,"publication_date":"2008-03-26","ids":{"openalex":"https://openalex.org/W2033471108","doi":"https://doi.org/10.1074/jbc.m706494200","mag":"2033471108","pmid":"https://pubmed.ncbi.nlm.nih.gov/18364355","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2475696"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m706494200","doi":"https://doi.org/10.1074/jbc.m706494200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m706494200","pdf_url":"http://www.jbc.org/article/S002192581954683X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581954683X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110061781","display_name":"Hyuntae Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hyuntae Yoo","raw_affiliation_strings":["Department of Chemistry and Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060360737","display_name":"Maciek R. Antoniewicz","orcid":"https://orcid.org/0000-0002-0087-2875","observed_orcids":["https://orcid.org/0000-0002-0087-2875"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maciek R. Antoniewicz","raw_affiliation_strings":["Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110867449","display_name":"Joanne K. Kelleher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joanne K. Kelleher","raw_affiliation_strings":["Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060360737","https://openalex.org/A5110061781","https://openalex.org/A5110867449"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.1313,"has_fulltext":true,"cited_by_count":302,"citation_normalized_percentile":{"value":0.9492627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"283","issue":"30","first_page":"20621","last_page":"20627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.2443999946117401,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0908999964594841,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reductive-carboxylation","display_name":"reductive carboxylation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/brown-adipocytes","display_name":"brown adipocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.6949999928474426},{"id":"https://openalex.org/keywords/isocitrate-dehydrogenase","display_name":"isocitrate dehydrogenase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mass-isotopomer-distributions","display_name":"mass isotopomer distributions","score":0.7020000219345093},{"id":"https://openalex.org/keywords/flux-analysis","display_name":"flux analysis","score":0.4259999990463257},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.5099999904632568},{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7087184190750122},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5672852396965027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5390339493751526},{"id":"https://openalex.org/C24428623","wikidata":"https://www.wikidata.org/wiki/Q901081","display_name":"Carboxylation","level":3,"score":0.5035466551780701},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4988706111907959},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4767209589481354},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33290550112724304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2819603681564331},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11871963739395142},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10365694761276245},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.06900542974472046},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000105","descriptor_name":"Acetyl Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010070","descriptor_name":"Oxalates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052437","descriptor_name":"Adipocytes, Brown","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m706494200","doi":"https://doi.org/10.1074/jbc.m706494200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m706494200","pdf_url":"http://www.jbc.org/article/S002192581954683X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1931232","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2475696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2475696","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2475696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:18364355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18364355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m706494200","doi":"https://doi.org/10.1074/jbc.m706494200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m706494200","pdf_url":"http://www.jbc.org/article/S002192581954683X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7875077486","display_name":"Elucidating modulators of hepatic metabolism by quantitative flux analysis","funder_award_id":"R01DK075850","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320310143","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033471108.pdf","grobid_xml":"https://content.openalex.org/works/W2033471108.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W10140315","https://openalex.org/W31596435","https://openalex.org/W133863196","https://openalex.org/W1489331825","https://openalex.org/W1542309964","https://openalex.org/W1754310888","https://openalex.org/W1811132283","https://openalex.org/W1916510256","https://openalex.org/W1972806358","https://openalex.org/W1978777057","https://openalex.org/W1980738702","https://openalex.org/W2005093036","https://openalex.org/W2014323212","https://openalex.org/W2016253024","https://openalex.org/W2039701153","https://openalex.org/W2055425726","https://openalex.org/W2065785909","https://openalex.org/W2072361374","https://openalex.org/W2072885613","https://openalex.org/W2073947892","https://openalex.org/W2075636558","https://openalex.org/W2086719628","https://openalex.org/W2092493462","https://openalex.org/W2101986593","https://openalex.org/W2108648814","https://openalex.org/W2131960328"],"related_works":["https://openalex.org/W2005093036","https://openalex.org/W2215229515","https://openalex.org/W2040780833","https://openalex.org/W1971050223","https://openalex.org/W2116516144","https://openalex.org/W2016253024","https://openalex.org/W2082158946","https://openalex.org/W2328727275","https://openalex.org/W2924911015","https://openalex.org/W1963816254"],"abstract_inverted_index":{"We":[0,103],"previously":[1],"reported":[2],"that":[3,96,118],"glutamine":[4,30,122,152,201,217],"was":[5],"a":[6,18,197,203,230],"major":[7],"source":[8],"of":[9,34,61,91,107,121,148,151,216],"carbon":[10],"for":[11,25,146,200,238],"de":[12],"novo":[13],"fatty":[14,26],"acid":[15,27,43,51,64,126],"synthesis":[16,28],"in":[17,59,73,81],"brown":[19,78],"adipocyte":[20,79],"cell":[21,169],"line.":[22],"The":[23,45,115,141,155],"pathway":[24,47,57,213],"from":[29,66],"may":[31],"follow":[32],"either":[33],"two":[35],"distinct":[36],"pathways":[37,75],"after":[38],"it":[39],"enters":[40],"the":[41,49,54,62,87,98,124,135,187,211],"citric":[42,50,63,125],"cycle.":[44],"glutaminolysis":[46,212],"follows":[48],"cycle,":[52],"whereas":[53],"reductive":[55,132,142,161,223],"carboxylation":[56,133,143,162],"travels":[58,128],"reverse":[60],"cycle":[65,127],"alpha-ketoglutarate":[67,172],"to":[68,101,129,153,210,218],"citrate.":[69],"To":[70],"quantify":[71],"fluxes":[72],"these":[74,184,194],"we":[76],"incubated":[77],"cells":[80],"[U-(13)C]glutamine":[82],"or":[83],"[5-(13)C]glutamine":[84],"and":[85,111,171,206,234],"analyzed":[86],"mass":[88],"isotopomer":[89,99],"distribution":[90,100],"key":[92],"metabolites":[93],"using":[94],"models":[95],"fit":[97],"fluxes.":[102],"also":[104],"investigated":[105],"inhibitors":[106],"NADP-dependent":[108],"isocitrate":[109,166],"dehydrogenase":[110],"mitochondrial":[112,165,188],"citrate":[113,130,170],"export.":[114],"results":[116],"indicated":[117],"one":[119],"third":[120],"entering":[123],"via":[131,222],"while":[134],"remainder":[136],"is":[137],"oxidized":[138],"through":[139,164],"succinate.":[140],"flux":[144,150,163,215,240],"accounted":[145],"90%":[147],"all":[149],"lipid.":[154],"inhibitor":[156],"studies":[157,195],"were":[158,173,227],"compatible":[159],"with":[160],"dehydrogenase.":[167],"Total":[168],"near":[174],"isotopic":[175],"equilibrium":[176],"as":[177,202],"expected":[178],"if":[179],"rapid":[180],"cycling":[181],"exists":[182],"between":[183],"compounds":[185],"involving":[186],"membrane":[189],"NAD/NADP":[190],"transhydrogenase.":[191],"Taken":[192],"together,":[193],"demonstrate":[196],"new":[198,231],"role":[199],"lipogenic":[204,219],"precursor":[205],"propose":[207],"an":[208],"alternative":[209],"where":[214],"acetyl-CoA":[220],"occurs":[221],"carboxylation.":[224],"These":[225],"findings":[226],"enabled":[228],"by":[229],"modeling":[232],"tool":[233],"software":[235],"implementation":[236],"(Metran)":[237],"global":[239],"estimation.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}