{"id":"https://openalex.org/W2033465348","doi":"https://doi.org/10.1016/j.gde.2004.12.009","title":"Mutational analysis of gene families in human cancer","display_name":"Mutational analysis of gene families in human cancer","publication_year":2004,"publication_date":"2004-12-24","ids":{"openalex":"https://openalex.org/W2033465348","doi":"https://doi.org/10.1016/j.gde.2004.12.009","mag":"2033465348","pmid":"https://pubmed.ncbi.nlm.nih.gov/15661527"},"language":"en","primary_location":{"id":"doi:10.1016/j.gde.2004.12.009","doi":"https://doi.org/10.1016/j.gde.2004.12.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2004.12.009","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics & Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064011158","display_name":"Alberto Bardelli","orcid":"https://orcid.org/0000-0003-1647-5070","observed_orcids":["https://orcid.org/0000-0003-1647-5070"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alberto Bardelli","raw_affiliation_strings":["The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (To), Italy. a.bardelli@unito.it","The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (To), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (To), Italy. a.bardelli@unito.it","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]},{"raw_affiliation_string":"The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (To), Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006560755","display_name":"Victor E. Velculescu","orcid":"https://orcid.org/0000-0003-1195-438X","observed_orcids":["https://orcid.org/0000-0003-1195-438X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victor E Velculescu","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006560755","https://openalex.org/A5064011158"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210151091","https://openalex.org/I4210164401","https://openalex.org/I55143463"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.3367,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.39351852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"5","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutation-analysis","display_name":"mutation analysis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/gene-family","display_name":"gene family","score":0.9700000286102295},{"id":"https://openalex.org/keywords/human-tumors","display_name":"human cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8190000057220459},{"id":"https://openalex.org/keywords/kinases","display_name":"kinases","score":0.9629999995231628},{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.8920000195503235},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8418734073638916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6568483114242554},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.65618896484375},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.6188427209854126},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5953896045684814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5888937711715698},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.5611950755119324},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.49953699111938477},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4958392083644867},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48951852321624756},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.44445809721946716},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3396740257740021},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11278292536735535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08933776617050171},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016045","descriptor_name":"Human Genome Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.gde.2004.12.009","doi":"https://doi.org/10.1016/j.gde.2004.12.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2004.12.009","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics & Development","raw_type":"journal-article"},{"id":"pmid:15661527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15661527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in genetics & development","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/31204","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/31204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2899213437","display_name":null,"funder_award_id":"CA 57345","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3900205185","display_name":null,"funder_award_id":"CA43460","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8373782936","display_name":"SPORE in Gastrointestinal Cancers","funder_award_id":"P50CA062924","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G970037175","display_name":null,"funder_award_id":"CA 62924","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1607745684","https://openalex.org/W1639582946","https://openalex.org/W1970847438","https://openalex.org/W1971278063","https://openalex.org/W1985035689","https://openalex.org/W1990281533","https://openalex.org/W1992945955","https://openalex.org/W1995088117","https://openalex.org/W1995414238","https://openalex.org/W1996729627","https://openalex.org/W1998947396","https://openalex.org/W2000771269","https://openalex.org/W2011912935","https://openalex.org/W2013973825","https://openalex.org/W2014923568","https://openalex.org/W2030205108","https://openalex.org/W2043617798","https://openalex.org/W2043696829","https://openalex.org/W2049449785","https://openalex.org/W2055614052","https://openalex.org/W2058743530","https://openalex.org/W2062116003","https://openalex.org/W2067040565","https://openalex.org/W2079977894","https://openalex.org/W2080175465","https://openalex.org/W2082777785","https://openalex.org/W2094548766","https://openalex.org/W2096371251","https://openalex.org/W2099224719","https://openalex.org/W2101214437","https://openalex.org/W2102140136","https://openalex.org/W2108914190","https://openalex.org/W2119415736","https://openalex.org/W2120718661","https://openalex.org/W2121695889","https://openalex.org/W2122673439","https://openalex.org/W2129172946","https://openalex.org/W2139236349","https://openalex.org/W2141885858","https://openalex.org/W2154692501","https://openalex.org/W2161821474","https://openalex.org/W2163188200","https://openalex.org/W2257356373","https://openalex.org/W2329648702","https://openalex.org/W3147254695","https://openalex.org/W7095600766"],"related_works":["https://openalex.org/W2144497460","https://openalex.org/W7099793199","https://openalex.org/W2230762127","https://openalex.org/W1984268193","https://openalex.org/W2616865409","https://openalex.org/W1978553451","https://openalex.org/W2132751137","https://openalex.org/W2085070983","https://openalex.org/W1542117945","https://openalex.org/W2352779628"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}