{"id":"https://openalex.org/W2033341963","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.281","title":"Ablative Local Therapy Extends the Clinical Benefit of Crizotinib in Alk-positive Lung Cancer","display_name":"Ablative Local Therapy Extends the Clinical Benefit of Crizotinib in Alk-positive Lung Cancer","publication_year":2012,"publication_date":"2012-10-25","ids":{"openalex":"https://openalex.org/W2033341963","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.281","mag":"2033341963"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2012.07.281","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.281","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2012.07.281","pdf_url":"http://www.redjournal.org/article/S0360301612012254/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.redjournal.org/article/S0360301612012254/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044093871","display_name":"Gregory N. Gan","orcid":"https://orcid.org/0000-0001-5090-0064","observed_orcids":["https://orcid.org/0000-0001-5090-0064"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.N. Gan","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082517668","display_name":"D. Ross Camidge","orcid":"https://orcid.org/0000-0003-3430-3213","observed_orcids":["https://orcid.org/0000-0003-3430-3213"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.R. Camidge","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044715236","display_name":"Andrew James Weickhardt","orcid":"https://orcid.org/0000-0002-6482-9681","observed_orcids":["https://orcid.org/0000-0002-6482-9681"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.J. Weickhardt","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034705456","display_name":"Robert Charles Doebele","orcid":"https://orcid.org/0000-0001-6728-6857","observed_orcids":["https://orcid.org/0000-0001-6728-6857"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.C. Doebele","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070076045","display_name":"Wayne Dzingle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Dzingle","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005886886","display_name":"Benjamin Y. Scheier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Scheier","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052966036","display_name":"Brian D. Kavanagh","orcid":"https://orcid.org/0000-0001-5579-1725","observed_orcids":["https://orcid.org/0000-0001-5579-1725"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.D. Kavanagh","raw_affiliation_strings":["University of Colorado Denver, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1504488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"3","first_page":"S67","last_page":"S68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/alk-positive-non-small-cell-lung-cancer","display_name":"ALK-positive non-small cell lung cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oligoprogression","display_name":"oligoprogression","score":0.8970000147819519},{"id":"https://openalex.org/keywords/crizotinib-resistance","display_name":"crizotinib resistance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/suvmax","display_name":"SUVmax","score":0.8640000224113464},{"id":"https://openalex.org/keywords/metabolic-tumor-volume","display_name":"metabolic tumor volume","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9392596483230591},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.9324609041213989},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6471525430679321},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.567025363445282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5167593359947205},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4910461902618408},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4684479534626007},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ijrobp.2012.07.281","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.281","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2012.07.281","pdf_url":"http://www.redjournal.org/article/S0360301612012254/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ijrobp.2012.07.281","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.281","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2012.07.281","pdf_url":"http://www.redjournal.org/article/S0360301612012254/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033341963.pdf","grobid_xml":"https://content.openalex.org/works/W2033341963.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2898175629","https://openalex.org/W2030227571","https://openalex.org/W2898536080","https://openalex.org/W7197035206","https://openalex.org/W2139483106","https://openalex.org/W2602210469","https://openalex.org/W2036896519","https://openalex.org/W2928412052","https://openalex.org/W2611405279","https://openalex.org/W2767715369"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}