{"id":"https://openalex.org/W2033338296","doi":"https://doi.org/10.1371/journal.pone.0123978","title":"Differential Impact of Relative Dose-Intensity Reductions in Diffuse Large B-Cell Lymphoma Treated with R-CHOP21 or R-CHOP14","display_name":"Differential Impact of Relative Dose-Intensity Reductions in Diffuse Large B-Cell Lymphoma Treated with R-CHOP21 or R-CHOP14","publication_year":2015,"publication_date":"2015-04-24","ids":{"openalex":"https://openalex.org/W2033338296","doi":"https://doi.org/10.1371/journal.pone.0123978","mag":"2033338296","pmid":"https://pubmed.ncbi.nlm.nih.gov/25909361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4409365"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0123978","doi":"https://doi.org/10.1371/journal.pone.0123978","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0123978","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123978&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123978&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006074198","display_name":"Antonio M. Gutierrez","orcid":"https://orcid.org/0000-0001-9062-077X","observed_orcids":["https://orcid.org/0000-0001-9062-077X"]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio Guti\u00e9rrez","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003809364","display_name":"Leyre Bento","orcid":"https://orcid.org/0000-0001-9929-8617","observed_orcids":["https://orcid.org/0000-0001-9929-8617"]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Leyre Bento","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065241418","display_name":"Antonia Mar\u00eda Bautista-Gili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonia Maria Bautista-Gili","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068975608","display_name":"Francesc Garc\u00eda\u2010Pallarols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francesc Garcia","raw_affiliation_strings":["Hematology Department, Hospital del Mar, Barcelona, Spain","Oncology Department, University Hospital Son Espases, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]},{"raw_affiliation_string":"Oncology Department, University Hospital Son Espases, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110721408","display_name":"Jordi Mart\u00ednez-Serra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Martinez-Serra","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103690660","display_name":"Blanca S\u00e1nchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca Sanchez","raw_affiliation_strings":["Hematology Department, Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075000513","display_name":"C. Nicolau Martorell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Clara Martorell","raw_affiliation_strings":["Pharmacy Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108408994","display_name":"Jordi Gin\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Gines","raw_affiliation_strings":["Pharmacy Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007139199","display_name":"Luc\u00eda Garc\u00eda","orcid":"https://orcid.org/0000-0001-6589-2781","observed_orcids":["https://orcid.org/0000-0001-6589-2781"]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lucia Garcia","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067708412","display_name":"Eva Gimeno","orcid":"https://orcid.org/0000-0002-3534-6189","observed_orcids":["https://orcid.org/0000-0002-3534-6189"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Gimeno","raw_affiliation_strings":["Hematology Department, Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078093996","display_name":"Mariana Paola Ferraro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mariana Ferraro","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015753706","display_name":"Raquel Del Campo","orcid":"https://orcid.org/0000-0002-1504-4730","observed_orcids":["https://orcid.org/0000-0002-1504-4730"]},"institutions":[{"id":"https://openalex.org/I4210087626","display_name":"Hospital Son Llatzer","ror":"https://ror.org/003ez4w63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210087626"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Del Campo","raw_affiliation_strings":["Hematology Department, Son Llatzer Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Llatzer Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210087626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035866456","display_name":"Joan Bargay","orcid":"https://orcid.org/0000-0002-6739-3916","observed_orcids":["https://orcid.org/0000-0002-6739-3916"]},"institutions":[{"id":"https://openalex.org/I4210087626","display_name":"Hospital Son Llatzer","ror":"https://ror.org/003ez4w63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210087626"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan Bargay","raw_affiliation_strings":["Hematology Department, Son Llatzer Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Llatzer Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210087626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109321035","display_name":"Albert P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Albert Perez","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037263853","display_name":"Javier Vercher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135574","display_name":"Hospital Can Misses","ror":"https://ror.org/03q0mrg27","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135574"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Vercher","raw_affiliation_strings":["Hematology Department, Can Misses Hospital, Ibiza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Can Misses Hospital, Ibiza, Spain","institution_ids":["https://openalex.org/I4210135574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086818120","display_name":"Miguel Scaff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104708","display_name":"Fundaci\u00f3n Hospital Manacor","ror":"https://ror.org/01dmnvb64","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210104708"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Scaff","raw_affiliation_strings":["Hematology Department, Hospital of Manacor, Manacor, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital of Manacor, Manacor, Spain","institution_ids":["https://openalex.org/I4210104708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102921736","display_name":"ANA PAULA DA SILVA PACHECO","orcid":"https://orcid.org/0009-0007-7189-0062","observed_orcids":["https://orcid.org/0009-0007-7189-0062"]},"institutions":[{"id":"https://openalex.org/I4210121232","display_name":"Hospital General Mateu Orfila","ror":"https://ror.org/01xst2e75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210121232"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Pacheco","raw_affiliation_strings":["Hematology Department, Mateu Orfila Hospital, Mahon, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Mateu Orfila Hospital, Mahon, Spain","institution_ids":["https://openalex.org/I4210121232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022554263","display_name":"Carm\u00e9n Ballester","orcid":"https://orcid.org/0009-0009-9436-9370","observed_orcids":["https://orcid.org/0009-0009-9436-9370"]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Ballester","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084240123","display_name":"Florencia Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Florencia Garcia","raw_affiliation_strings":["Hematology Department, Hospital del Mar, Barcelona, Spain","Oncology Department, University Hospital Son Espases, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]},{"raw_affiliation_string":"Oncology Department, University Hospital Son Espases, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103970825","display_name":"Rafael F. Ramos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Ramos","raw_affiliation_strings":["Pathology Department, University Hospital Son Espases, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, University Hospital Son Espases, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010206363","display_name":"Antonio Salar","orcid":"https://orcid.org/0000-0002-4652-4825","observed_orcids":["https://orcid.org/0000-0002-4652-4825"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Salar","raw_affiliation_strings":["Hematology Department, Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081168775","display_name":"Joan Besalduch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan Besalduch","raw_affiliation_strings":["Hematology Department, Son Espases University Hospital, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Son Espases University Hospital, Palma, Spain","institution_ids":["https://openalex.org/I4210152826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006074198"],"corresponding_institution_ids":["https://openalex.org/I4210152826"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6573,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84180938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"10","issue":"4","first_page":"e0123978","last_page":"e0123978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/relative-dose-intensity","display_name":"relative dose intensity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/dose-density","display_name":"dose density","score":0.4830000102519989},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9789999723434448},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/international-prognostic-index","display_name":"International Prognostic Index","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bulky-disease","display_name":"bulky disease","score":0.8799999952316284},{"id":"https://openalex.org/keywords/b-symptoms","display_name":"B symptoms","score":0.8199999928474426},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.732160210609436},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.5944013595581055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5787279009819031},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5480626821517944},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3818463087081909},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35406678915023804}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058846","descriptor_name":"Antibodies, Monoclonal, Murine-Derived","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0123978","doi":"https://doi.org/10.1371/journal.pone.0123978","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0123978","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123978&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3388756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4409365","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25909361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25909361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4409365","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4409365/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d7e01404cc3342578811658f0dda65ea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d7e01404cc3342578811658f0dda65ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 4, p e0123978 (2015)","raw_type":"article"},{"id":"pmh:oai:docusalut.com:20.500.13003/10877","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.13003/10877","pdf_url":null,"source":{"id":"https://openalex.org/S4306402504","display_name":"Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089844","host_organization_name":"Servei de Salut de les Illes Balears","host_organization_lineage":["https://openalex.org/I4210089844"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:hispana.mcu.es:57577898","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.13003/10877","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:repositori.upf.edu:10230/23650","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/23650","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0123978","doi":"https://doi.org/10.1371/journal.pone.0123978","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0123978","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123978&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033338296.pdf","grobid_xml":"https://content.openalex.org/works/W2033338296.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W117021016","https://openalex.org/W1549268762","https://openalex.org/W1580788756","https://openalex.org/W1605230984","https://openalex.org/W1641876683","https://openalex.org/W1899541887","https://openalex.org/W1912693401","https://openalex.org/W1933587402","https://openalex.org/W1979300931","https://openalex.org/W1990148861","https://openalex.org/W2035811581","https://openalex.org/W2038252730","https://openalex.org/W2058015212","https://openalex.org/W2063691874","https://openalex.org/W2066561309","https://openalex.org/W2072351874","https://openalex.org/W2078719089","https://openalex.org/W2102030459","https://openalex.org/W2106810047","https://openalex.org/W2108465006","https://openalex.org/W2133120925","https://openalex.org/W2142195688","https://openalex.org/W2152124377","https://openalex.org/W2152474929","https://openalex.org/W2152807596","https://openalex.org/W2153665789","https://openalex.org/W2156636734","https://openalex.org/W2166900358","https://openalex.org/W2169403306","https://openalex.org/W2171356556","https://openalex.org/W2235063564","https://openalex.org/W2254092548","https://openalex.org/W2318772898","https://openalex.org/W2416340253","https://openalex.org/W2605539363","https://openalex.org/W2741983725","https://openalex.org/W2914878951","https://openalex.org/W3041047318","https://openalex.org/W3147894994","https://openalex.org/W4205736005"],"related_works":["https://openalex.org/W2556509969","https://openalex.org/W2396727612","https://openalex.org/W2915736552","https://openalex.org/W2962584716","https://openalex.org/W2558349019","https://openalex.org/W2564840906","https://openalex.org/W2584378227","https://openalex.org/W3158033047","https://openalex.org/W2895858698","https://openalex.org/W2895403217"],"abstract_inverted_index":{"DLBCL":[0,67,82],"is":[1,37,43],"an":[2,232],"aggressive":[3],"lymphoma":[4],"treated":[5,69,85],"with":[6,70,86,90,170],"R-CHOP.":[7],"Recently,":[8],"attempts":[9],"have":[10,25],"been":[11,26],"made":[12,231],"to":[13,39,55,77,115,273],"improve":[14],"the":[15,57,119,125,141,146,150,188,225,235],"outcome":[16],"by":[17],"increasing":[18],"both":[19,153],"dose-density":[20],"and":[21,104,128,163,194,205,242,251,268],"intensity":[22],"but":[23,41,228,253],"there":[24,42],"no":[27,138],"benefits":[28],"in":[29,63,140,159,178,224,234,247,271],"terms":[30,248],"of":[31,51,61,66,102,108,220,249],"survival.":[32],"When":[33],"treating":[34],"malignancies":[35],"RDI":[36,62,160,179,221,256,275],"important":[38],"consider":[40],"little":[44],"published":[45],"information":[46],"on":[47],"DLBCL.":[48],"The":[49],"purpose":[50],"this":[52],"study":[53],"was":[54,133,137,182,213],"analyze":[56],"differential":[58],"prognostic":[59],"impact":[60,233],"two":[64,147],"cohorts":[65],"patients":[68,83,120,261],"R-CHOP21":[71,87,151,236,241,263],"or":[72,88,91,143],"R-CHOP14.":[73],"From":[74],"January":[75],"2001":[76],"August":[78],"2013":[79],"we":[80,264],"included":[81],"homogenously":[84],"R-CHOP14,":[89],"without":[92],"radiotherapy,":[93],"at":[94],"University":[95],"Hospital":[96,99,105],"Son":[97,100],"Espases,":[98],"Llatzer":[101],"Palma":[103],"del":[106],"Mar":[107],"Barcelona":[109],"(N":[110],"=":[111],"157).":[112],"In":[113,149,187],"order":[114,272],"avoid":[116,274],"selection":[117],"bias":[118],"were":[121,167],"retrospectively":[122],"identified":[123],"from":[124],"Pathology":[126],"Department":[127],"Pharmacy":[129],"registries.":[130],"Median":[131],"follow-up":[132],"68":[134],"months.":[135],"There":[136,212],"difference":[139],"response":[142,250],"survival":[144],"between":[145],"cohorts.":[148],"group,":[152,190],"a":[154,173,214,217],"reduction":[155,174,222],"higher":[156,175,218],"than":[157,176],"15%":[158,177],"(RR":[161,165,180,192,196,203,208],"7.41)":[162],"R-IPI":[164],"2.99)":[166],"independently":[168],"associated":[169],"OS.":[171],"However,":[172],"4.41)":[181],"only":[183,230,254],"noted":[184],"for":[185,198,210],"PFS.":[186,211],"R-CHOP14":[189,226,243],"NCCN-IPI":[191],"7.09)":[193],"B-symptoms":[195],"5.37)":[197],"OS;":[199],"AA":[200],"stage":[201],"III-IV":[202],"6.26)":[204],"bulky":[206],"disease":[207],"4.05)":[209],"trend":[215],"towards":[216],"rate":[219],"observed":[223],"group":[227],"it":[229],"group.":[237],"We":[238],"conclude":[239],"that":[240],"are":[244,258],"equivalent":[245],"regimens":[246],"survival,":[252],"if":[255],"reductions":[257],"avoided.":[259],"For":[260],"receiving":[262],"recommend":[265],"using":[266],"clinical":[267],"support":[269],"measures":[270],"reductions.":[276]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}