{"id":"https://openalex.org/W2033337283","doi":"https://doi.org/10.1126/science.3001938","title":"Irreversible Block of the Mycelial-to-Yeast Phase Transition of Histoplasma capsulatum","display_name":"Irreversible Block of the Mycelial-to-Yeast Phase Transition of Histoplasma capsulatum","publication_year":1986,"publication_date":"1986-01-31","ids":{"openalex":"https://openalex.org/W2033337283","doi":"https://doi.org/10.1126/science.3001938","mag":"2033337283","pmid":"https://pubmed.ncbi.nlm.nih.gov/3001938"},"language":"en","primary_location":{"id":"doi:10.1126/science.3001938","doi":"https://doi.org/10.1126/science.3001938","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3001938","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007105955","display_name":"Gerald Medoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Medoff","raw_affiliation_strings":["Departments of Internal Medicine and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, MO 63110","Infectious Diseases Division of Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Infectious Diseases Division of Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110255528","display_name":"Margherita Sacco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Sacco","raw_affiliation_strings":["Istituto Intemazionale di Genetica e Biofisica, CNR, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Intemazionale di Genetica e Biofisica, CNR, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047637129","display_name":"Bruno Maresca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bruno Maresca","raw_affiliation_strings":["Istituto Intemazionale di Genetica e Biofisica, CNR, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Intemazionale di Genetica e Biofisica, CNR, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079340049","display_name":"David Schlessinger","orcid":"https://orcid.org/0000-0002-4622-3352","observed_orcids":["https://orcid.org/0000-0002-4622-3352"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Schlessinger","raw_affiliation_strings":["Departments of Internal Medicine and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111870096","display_name":"Audrey A. Painter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Painter","raw_affiliation_strings":["Infectious Diseases Division of Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Division of Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111812095","display_name":"George S. Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George S. Kobayashi","raw_affiliation_strings":["Departments of Internal Medicine and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021155403","display_name":"Luisella Carrat\u00f9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisella Carratu","raw_affiliation_strings":["Istituto Intemazionale di Genetica e Biofisica, CNR, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Intemazionale di Genetica e Biofisica, CNR, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5548,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.92712622,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"231","issue":"4737","first_page":"476","last_page":"479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histoplasma-capsulatum","display_name":"Histoplasma capsulatum","score":1.0},{"id":"https://openalex.org/keywords/dimorphic-fungi","display_name":"dimorphic fungi","score":0.8109999895095825},{"id":"https://openalex.org/keywords/p-chloromercuriphenylsulfonic-acid","display_name":"p-chloromercuriphenylsulfonic acid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sulfhydryl-inhibitors","display_name":"sulfhydryl inhibitors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.6290000081062317},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.5370000004768372},{"id":"https://openalex.org/keywords/murine-infection","display_name":"mouse infection","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C133479454","wikidata":"https://www.wikidata.org/wiki/Q326228","display_name":"Mycelium","level":2,"score":0.9374673366546631},{"id":"https://openalex.org/C2778803964","wikidata":"https://www.wikidata.org/wiki/Q143747","display_name":"Histoplasma capsulatum","level":3,"score":0.8987395763397217},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.8530893921852112},{"id":"https://openalex.org/C21717790","wikidata":"https://www.wikidata.org/wiki/Q3291858","display_name":"Dimorphic fungus","level":3,"score":0.7540392875671387},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6615591049194336},{"id":"https://openalex.org/C2777802930","wikidata":"https://www.wikidata.org/wiki/Q10941019","display_name":"Histoplasma","level":4,"score":0.579209566116333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5287662744522095},{"id":"https://openalex.org/C2775839086","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Pathogenic fungus","level":3,"score":0.5202480554580688},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.47053655982017517},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4345702528953552},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.4164561629295349},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.23137634992599487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16409635543823242},{"id":"https://openalex.org/C2780318139","wikidata":"https://www.wikidata.org/wiki/Q627625","display_name":"Histoplasmosis","level":2,"score":0.10625824332237244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.05696257948875427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04605752229690552}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002731","descriptor_name":"4-Chloromercuribenzenesulfonate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006658","descriptor_name":"Histoplasma","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006658","descriptor_name":"Histoplasma","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D006658","descriptor_name":"Histoplasma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006660","descriptor_name":"Histoplasmosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.3001938","doi":"https://doi.org/10.1126/science.3001938","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3001938","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:3001938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3001938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unicampania.it:11591/221630","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/221630","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2966729015","display_name":null,"funder_award_id":"AI 07015","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8725122132","display_name":"MEDICAL MYCOLOGY","funder_award_id":"P01AI016228","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000875762","display_name":"Infectious Disease/Basic Microbial Pathogenic Mechanisms","funder_award_id":"T32AI007172","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1252201420","https://openalex.org/W1531234934","https://openalex.org/W1546120922","https://openalex.org/W1556589772","https://openalex.org/W1919158126","https://openalex.org/W1970395142","https://openalex.org/W1978781393","https://openalex.org/W2008578126","https://openalex.org/W2015387867","https://openalex.org/W2019188970","https://openalex.org/W2019840836","https://openalex.org/W2036122175","https://openalex.org/W2037906550","https://openalex.org/W2061090948","https://openalex.org/W2065925457","https://openalex.org/W2066347579","https://openalex.org/W2088931192","https://openalex.org/W2090416567","https://openalex.org/W2099200936","https://openalex.org/W2139584976","https://openalex.org/W2168269215"],"related_works":["https://openalex.org/W1915674390","https://openalex.org/W2404615547","https://openalex.org/W2084987400","https://openalex.org/W2155014461","https://openalex.org/W2077598481","https://openalex.org/W2088931192","https://openalex.org/W244326789","https://openalex.org/W6983530328","https://openalex.org/W2069103263","https://openalex.org/W1951272385"],"abstract_inverted_index":{"p-Chloromercuriphenylsulfonic":[0],"acid":[1],"(PCMS),":[2],"a":[3,71,80],"sulfhydryl":[4],"inhibitor,":[5],"prevented":[6],"the":[7,11,24,35,42],"mycelial-to-yeast":[8,25],"transition":[9],"of":[10,19,33,47,74],"dimorphic":[12,91],"fungal":[13],"pathogen,":[14],"Histoplasma":[15,75],"capsulatum.":[16,76],"The":[17,45],"effect":[18,30],"PCMS":[20],"was":[21,54],"specific":[22],"for":[23,84],"transformation;":[26],"it":[27],"had":[28],"no":[29],"on":[31,41],"growth":[32],"either":[34],"yeast":[36,53],"or":[37,40],"mycelial":[38],"forms":[39],"yeast-to-mycelial":[43],"transition.":[44],"failure":[46],"PCMS-treated":[48,58],"mycelia":[49,59],"to":[50,52,68],"transform":[51],"permanent":[55],"and":[56],"irreversible.":[57],"could":[60,65],"not":[61],"infect":[62],"mice":[63],"but":[64],"stimulate":[66],"resistance":[67],"infection":[69],"by":[70,90],"pathogenic":[72],"strain":[73],"These":[77],"results":[78],"suggest":[79],"new":[81],"general":[82],"strategy":[83],"vaccine":[85],"development":[86],"in":[87],"diseases":[88],"caused":[89],"pathogens.":[92]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
