{"id":"https://openalex.org/W2033247996","doi":"https://doi.org/10.1016/0041-008x(87)90270-5","title":"The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats","display_name":"The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W2033247996","doi":"https://doi.org/10.1016/0041-008x(87)90270-5","mag":"2033247996","pmid":"https://pubmed.ncbi.nlm.nih.gov/3564032"},"language":"en","primary_location":{"id":"doi:10.1016/0041-008x(87)90270-5","doi":"https://doi.org/10.1016/0041-008x(87)90270-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(87)90270-5","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008006547","display_name":"Donald M. Maxwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald M. Maxwell","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109074975","display_name":"David E. Lenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Lenz","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031026081","display_name":"William A. Groff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Groff","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074440518","display_name":"Andris Kaminskis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andris Kaminskis","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056145621","display_name":"Harry L. Froehlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry L. Froehlich","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, 21010-5425, USA","institution_ids":["https://openalex.org/I4210088792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008006547"],"corresponding_institution_ids":["https://openalex.org/I4210088792"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":5.0079,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.95068115,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"88","issue":"1","first_page":"66","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soman","display_name":"soman","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cholinesterase-inhibition","display_name":"cholinesterase inhibition","score":0.9459999799728394},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.859000027179718},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.6729999780654907},{"id":"https://openalex.org/keywords/tissue-blood-flow","display_name":"tissue blood flow","score":0.7419999837875366},{"id":"https://openalex.org/keywords/detoxification","display_name":"detoxification","score":0.6359999775886536},{"id":"https://openalex.org/keywords/carboxylesterase","display_name":"carboxylesterase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/diisopropyl-fluorophosphate","display_name":"diisopropylfluorophosphate","score":0.9179999828338623},{"id":"https://openalex.org/keywords/organophosphate-poisoning","display_name":"organophosphate poisoning","score":0.6470000147819519},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.4740000069141388},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.8159999847412109},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2780266723","wikidata":"https://www.wikidata.org/wiki/Q408044","display_name":"Soman","level":4,"score":0.911531925201416},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.8356565237045288},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.7260820269584656},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7219609022140503},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5248203873634338},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5208021402359009},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5182111859321594},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3948568105697632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24938175082206726},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.2347436249256134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21544727683067322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19425824284553528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1320255994796753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12670645117759705},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006867","descriptor_name":"Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012999","descriptor_name":"Soman","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044345","descriptor_name":"Phosphoric Triester Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0041-008x(87)90270-5","doi":"https://doi.org/10.1016/0041-008x(87)90270-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(87)90270-5","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:3564032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3564032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1512019646","https://openalex.org/W1672769285","https://openalex.org/W1747667807","https://openalex.org/W1971566556","https://openalex.org/W1972016267","https://openalex.org/W1986452745","https://openalex.org/W2007272869","https://openalex.org/W2019610610","https://openalex.org/W2024619105","https://openalex.org/W2028696484","https://openalex.org/W2028715861","https://openalex.org/W2031110696","https://openalex.org/W2042518718","https://openalex.org/W2046253951","https://openalex.org/W2046850657","https://openalex.org/W2050234871","https://openalex.org/W2060201297","https://openalex.org/W2067882777","https://openalex.org/W2074059351","https://openalex.org/W2097731489","https://openalex.org/W2122065234","https://openalex.org/W2152416963","https://openalex.org/W2175172617","https://openalex.org/W2402552551","https://openalex.org/W2414286919","https://openalex.org/W2415325935","https://openalex.org/W2418318023","https://openalex.org/W2501306189","https://openalex.org/W3022047930"],"related_works":["https://openalex.org/W2081686337","https://openalex.org/W2015575699","https://openalex.org/W2409418854","https://openalex.org/W2472102943","https://openalex.org/W2058239923","https://openalex.org/W2073324273","https://openalex.org/W2056928006","https://openalex.org/W1985833184","https://openalex.org/W2095989237","https://openalex.org/W2085221247"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
