{"id":"https://openalex.org/W2033210503","doi":"https://doi.org/10.1210/endo-83-6-1166","title":"Metabolic Effects of Insulin on Rat Kidney After Inhibiting Degradation of the Hormone","display_name":"Metabolic Effects of Insulin on Rat Kidney After Inhibiting Degradation of the Hormone","publication_year":1968,"publication_date":"1968-12-01","ids":{"openalex":"https://openalex.org/W2033210503","doi":"https://doi.org/10.1210/endo-83-6-1166","mag":"2033210503","pmid":"https://pubmed.ncbi.nlm.nih.gov/5721989"},"language":"en","primary_location":{"id":"doi:10.1210/endo-83-6-1166","doi":"https://doi.org/10.1210/endo-83-6-1166","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-83-6-1166","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111849909","display_name":"Richard J. Mahler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD J. MAHLER","raw_affiliation_strings":["Section of Endocrinology and Metabolism New York, New York 10029; Department of Medicine, New York Medical College New York, New York 10029","Department of Medicine, New York Medical College New York, New York 10029","Section of Endocrinology and Metabolism New York, New York 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Endocrinology and Metabolism New York, New York 10029; Department of Medicine, New York Medical College New York, New York 10029","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Medicine, New York Medical College New York, New York 10029","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Section of Endocrinology and Metabolism New York, New York 10029","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084918498","display_name":"Olga Szab\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"OLGA SZABO","raw_affiliation_strings":["Section of Endocrinology and Metabolism New York, New York 10029; Department of Medicine, New York Medical College New York, New York 10029","Department of Medicine, New York Medical College New York, New York 10029","Section of Endocrinology and Metabolism New York, New York 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Endocrinology and Metabolism New York, New York 10029; Department of Medicine, New York Medical College New York, New York 10029","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Medicine, New York Medical College New York, New York 10029","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Section of Endocrinology and Metabolism New York, New York 10029","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.046,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.74837592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"6","first_page":"1166","last_page":"1172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.05900000035762787,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-degradation","display_name":"insulin degradation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/insulin-metabolism","display_name":"insulin metabolism","score":0.652999997138977},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.6489999890327454},{"id":"https://openalex.org/keywords/alloxan","display_name":"alloxan","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.3330000042915344},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8488912582397461},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.8331924676895142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8085778951644897},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7824162840843201},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6162682771682739},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4255245625972748},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3846238851547241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31019484996795654},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2671439051628113}],"mesh":[{"descriptor_ui":"D000496","descriptor_name":"Alloxan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007456","descriptor_name":"Iodine Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011773","descriptor_name":"Pyruvates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-83-6-1166","doi":"https://doi.org/10.1210/endo-83-6-1166","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-83-6-1166","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:5721989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5721989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1566830427"],"related_works":["https://openalex.org/W2321134233","https://openalex.org/W2325960688","https://openalex.org/W2331536749","https://openalex.org/W2062619026","https://openalex.org/W2724852226","https://openalex.org/W1927888914","https://openalex.org/W1988787121","https://openalex.org/W2261123106","https://openalex.org/W2432956084","https://openalex.org/W2034482795"],"abstract_inverted_index":{"The":[0],"intravenous":[1],"administration":[2,81],"of":[3,14,16,31,41,50,55,86,115,121,148,155],"alloxan":[4,36,77,80,102],"(20":[5],"mg/100":[6],"g)":[7],"to":[8,38,83,132],"intact":[9],"rats":[10],"causes":[11,43],"marked":[12],"inhibition":[13],"destruction":[15,33],"135I":[17],"insulin.":[18],"Either":[19],"\u201cfunctional\u201d":[20,57],"evisceration":[21,58],"or":[22,109],"nephrectomy":[23,60],"results":[24],"in":[25,28,47,95,107,112,137],"40%":[26],"diminution":[27],"the":[29,48,113,146,152,158],"rate":[30,49,147],"insulin":[32,51,69,87,116,118,135,149,156],"and":[34,59,92,105,151],"prior":[35,76],"injection":[37],"both":[39],"groups":[40],"animals":[42,104,130],"still":[44,67],"further":[45,73],"reduction":[46],"degradation.":[52],"A":[53],"procedure":[54],"combined":[56],"is":[61,72],"followed":[62],"by":[63,75,89],"much":[64],"reduced":[65],"but":[66],"apparent":[68],"degradation,":[70],"which":[71],"inhibited":[74],"injection.":[78],"Thus,":[79],"appears":[82],"cause":[84],"impairment":[85],"degradation":[88,150],"liver,":[90],"kidney":[91,125],"possibly":[93],"other":[94],"vivo":[96],"sites.":[97],"Kidney":[98],"slices":[99,126],"obtained":[100],"from":[101,127],"injected":[103,129],"incubated":[106],"glucose":[108],"pyruvate":[110],"buffer":[111],"presence":[114],"demonstrate":[117,133],"enhanced":[119],"utilization":[120],"these":[122],"substrates,":[123],"whereas":[124],"saline":[128],"fail":[131],"an":[134],"effect":[136],"vitro.":[138],"These":[139],"observations":[140],"suggest":[141],"a":[142],"regulatory":[143],"role":[144],"between":[145],"biologic":[153],"effectiveness":[154],"upon":[157],"kidney.":[159],"(Endocrinology83:":[160],"1166,":[161],"1968)":[162]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
