{"id":"https://openalex.org/W2033186197","doi":"https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","title":"Wild-type and mutant forms ofv-src differentially alter neuronal migration and differentiation in vivo","display_name":"Wild-type and mutant forms ofv-src differentially alter neuronal migration and differentiation in vivo","publication_year":2000,"publication_date":"2000-01-15","ids":{"openalex":"https://openalex.org/W2033186197","doi":"https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","mag":"2033186197","pmid":"https://pubmed.ncbi.nlm.nih.gov/10650881"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","doi":"https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078787421","display_name":"John C. Morgan","orcid":"https://orcid.org/0000-0001-5279-5026","observed_orcids":["https://orcid.org/0000-0001-5279-5026"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Morgan","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912-2000, USA","Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912-2000, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta,","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072009238","display_name":"John E. Majors","orcid":"https://orcid.org/0000-0001-9857-9230","observed_orcids":["https://orcid.org/0000-0001-9857-9230"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Majors","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081857171","display_name":"Deni S. Galileo","orcid":"https://orcid.org/0000-0002-0089-2198","observed_orcids":["https://orcid.org/0000-0002-0089-2198"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deni S. Galileo","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081857171"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.2278,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.52712477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"2","first_page":"226","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/v-src","display_name":"v-Src","score":0.9580000042915344},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.6499999761581421},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.8849999904632568},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/radial-glial-cells","display_name":"radial glia","score":0.6990000009536743},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8149999976158142},{"id":"https://openalex.org/keywords/optic-tectum","display_name":"optic tectum","score":0.7789999842643738},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.7070000171661377},{"id":"https://openalex.org/keywords/embryonic-brain-development","display_name":"embryonic brain development","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tangential-migration","display_name":"tangential migration","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.8595548868179321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7780158519744873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5761204957962036},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5246515274047852},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4966047406196594},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.47817593812942505},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.47205764055252075},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4682667553424835},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3671947121620178},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3619702458381653},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32526350021362305},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2847055196762085},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25500255823135376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12906938791275024}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013477","descriptor_name":"Superior Colliculi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016391","descriptor_name":"Genes, src","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","doi":"https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<226::aid-jnr9>3.0.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:10650881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10650881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1524996824","https://openalex.org/W1531756231","https://openalex.org/W1667992367","https://openalex.org/W1817075347","https://openalex.org/W1824239451","https://openalex.org/W1891830703","https://openalex.org/W1910399711","https://openalex.org/W1918581737","https://openalex.org/W1958241920","https://openalex.org/W1966087966","https://openalex.org/W1971344067","https://openalex.org/W1978184416","https://openalex.org/W1979324468","https://openalex.org/W1984841015","https://openalex.org/W1985873746","https://openalex.org/W1988651587","https://openalex.org/W1988762432","https://openalex.org/W1991776568","https://openalex.org/W1998412502","https://openalex.org/W1999831963","https://openalex.org/W2000170431","https://openalex.org/W2003904482","https://openalex.org/W2008203029","https://openalex.org/W2009009539","https://openalex.org/W2016503493","https://openalex.org/W2031514932","https://openalex.org/W2031687737","https://openalex.org/W2034409530","https://openalex.org/W2037710468","https://openalex.org/W2039895922","https://openalex.org/W2046713890","https://openalex.org/W2047814166","https://openalex.org/W2050893705","https://openalex.org/W2060359861","https://openalex.org/W2064812124","https://openalex.org/W2066367871","https://openalex.org/W2091726041","https://openalex.org/W2104413763","https://openalex.org/W2106293814","https://openalex.org/W2108449104","https://openalex.org/W2140034535","https://openalex.org/W2142364395","https://openalex.org/W2142550741","https://openalex.org/W2144838141","https://openalex.org/W2154976496","https://openalex.org/W2161651018","https://openalex.org/W2164188891","https://openalex.org/W2255005089","https://openalex.org/W2277203213","https://openalex.org/W2277822186","https://openalex.org/W2313907974","https://openalex.org/W2361981071","https://openalex.org/W2402085029","https://openalex.org/W2435708663","https://openalex.org/W2472071666","https://openalex.org/W4301874737"],"related_works":["https://openalex.org/W1976689058","https://openalex.org/W1975433026","https://openalex.org/W2411874880","https://openalex.org/W1824239451","https://openalex.org/W2106293814","https://openalex.org/W2060359861","https://openalex.org/W1979324468","https://openalex.org/W2126659419","https://openalex.org/W1999214130","https://openalex.org/W1871067980"],"abstract_inverted_index":{"The":[0],"effects":[1,202],"of":[2,6,34,79,85,184,203],"three":[3],"different":[4],"forms":[5,33],"v-src":[7,27,35,139,153,167,176,204],"on":[8,64,205],"brain":[9,186,206],"cell":[10,80,88,97,118,131,160],"development":[11,161],"were":[12,40,56,90,120],"determined":[13],"in":[14,47,58,76,152,166,196],"vivo.":[15],"Recombinant":[16],"retroviral":[17,62],"vectors":[18],"encoding":[19],"the":[20,48,59],"marker":[21],"lacZ":[22],"(control)":[23],"and":[24,69,74,83,110,140,154,162,168,182,188],"either":[25],"wild-type":[26],"or":[28,30,37],"SH2":[29],"SH3":[31],"domain-deleted":[32],"(deltaSH2":[36],"deltaSH3,":[38],"respectively)":[39],"used":[41],"to":[42,94],"infect":[43],"neuronal":[44,134,145],"progenitor":[45],"cells":[46,187,207],"embryonic":[49,65],"chicken":[50],"midbrain":[51],"(optic":[52],"tectum;":[53],"OT).":[54],"Embryos":[55],"injected":[57],"OT":[60],"with":[61],"concentrates":[63],"day":[66],"(E)":[67],"3":[68],"sacrificed":[70],"at":[71,100],"E6,":[72],"E9,":[73,116],"later":[75],"development.":[77],"Patterns":[78],"proliferation,":[81,179],"migration,":[82,180],"differentiation":[84,163,183],"lacZ-marked":[86],"clonal":[87],"progeny":[89],"then":[91],"analyzed.":[92],"Relative":[93],"lacZ-only":[95],"controls,":[96,124],"clone":[98],"size":[99],"E6":[101],"was":[102,136,147,164],"significantly":[103,121],"increased":[104,126],"for":[105,108,112,138],"v-src-,":[106],"unchanged":[107],"deltaSH2-,":[109],"smaller":[111],"deltaSH3-injected":[113],"embryos.":[114],"At":[115],"deltaSH2":[117,155],"clones":[119],"larger":[122],"than":[123],"suggesting":[125],"survival":[127],"from":[128],"normal":[129],"programmed":[130],"death.":[132],"Radial":[133],"migration":[135,146],"impaired":[137],"deltaSH3":[141,169],"clones,":[142],"whereas":[143],"tangential":[144],"enhanced":[148],"along":[149],"fiber":[150],"tracts":[151],"clones.":[156,170],"Moreover,":[157],"radial":[158],"glial":[159],"hindered":[165],"These":[171],"experiments":[172],"demonstrate":[173],"that":[174,190],"ectopic":[175],"signaling":[177,192],"alters":[178],"survival,":[181],"developing":[185],"suggest":[189],"src":[191,210],"pathways":[193],"are":[194],"involved":[195],"these":[197],"developmental":[198],"processes.":[199],"Furthermore,":[200],"certain":[201],"require":[208],"specific":[209],"homology":[211],"domains.":[212]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}