{"id":"https://openalex.org/W2033081563","doi":"https://doi.org/10.1016/s0022-5347(05)66299-4","title":"URETHRA IS MORE SENSITIVE TO ISCHEMIA THAN BLADDER:","display_name":"URETHRA IS MORE SENSITIVE TO ISCHEMIA THAN BLADDER:","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W2033081563","doi":"https://doi.org/10.1016/s0022-5347(05)66299-4","mag":"2033081563","pmid":"https://pubmed.ncbi.nlm.nih.gov/11371933"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(05)66299-4","doi":"https://doi.org/10.1016/s0022-5347(05)66299-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(05)66299-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007706410","display_name":"Gennady Bratslavsky","orcid":"https://orcid.org/0000-0002-2712-4375","observed_orcids":["https://orcid.org/0000-0002-2712-4375"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]},{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GENNADY BRATSLAVSKY","raw_affiliation_strings":["From the Albany College of Medicine, Albany College of Pharmacy and Stratton Veterans Affairs Medical Center, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Albany College of Medicine, Albany College of Pharmacy and Stratton Veterans Affairs Medical Center, Albany, New York","institution_ids":["https://openalex.org/I365282","https://openalex.org/I4210109456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022002081","display_name":"Barry Kogan","orcid":"https://orcid.org/0000-0002-1396-5720","observed_orcids":["https://orcid.org/0000-0002-1396-5720"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]},{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BARRY KOGAN","raw_affiliation_strings":["From the Albany College of Medicine, Albany College of Pharmacy and Stratton Veterans Affairs Medical Center, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Albany College of Medicine, Albany College of Pharmacy and Stratton Veterans Affairs Medical Center, Albany, New York","institution_ids":["https://openalex.org/I365282","https://openalex.org/I4210109456"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]},{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT M. LEVIN","raw_affiliation_strings":["From the Albany College of Medicine, Albany College of Pharmacy and Stratton Veterans Affairs Medical Center, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Albany College of Medicine, Albany College of Pharmacy and Stratton Veterans Affairs Medical Center, Albany, New York","institution_ids":["https://openalex.org/I365282","https://openalex.org/I4210109456"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.515,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81226561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"165","issue":"6 Part 1","first_page":"2086","last_page":"2090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-ischemia","display_name":"bladder ischemia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/detrusor-muscle","display_name":"detrusor muscle","score":0.8259999752044678},{"id":"https://openalex.org/keywords/prostatic-urethra","display_name":"prostatic urethra","score":0.902999997138977},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neurogenic-dysfunction","display_name":"neurogenic dysfunction","score":0.7139999866485596},{"id":"https://openalex.org/keywords/urinary-incontinence","display_name":"urinary incontinence","score":0.9279999732971191},{"id":"https://openalex.org/keywords/electrical-field-stimulation","display_name":"electrical field stimulation","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.9000062942504883},{"id":"https://openalex.org/C2777085111","wikidata":"https://www.wikidata.org/wiki/Q9386","display_name":"Urethra","level":2,"score":0.8215702176094055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7693692445755005},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5640379786491394},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5209652185440063},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49991369247436523},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.4991581439971924},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4174022674560547},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3338462710380554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2909006178379059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10470220446586609},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014521","descriptor_name":"Urethra","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D014563","descriptor_name":"Urodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-5347(05)66299-4","doi":"https://doi.org/10.1016/s0022-5347(05)66299-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(05)66299-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"doi:10.1097/00005392-200106000-00075","doi":"https://doi.org/10.1097/00005392-200106000-00075","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-200106000-00075","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},{"id":"pmid:11371933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11371933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5051918649","display_name":"MOLECULAR PATHWAY TO BLADDER DYSFUNCTION","funder_award_id":"R01DK053965","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5634912814","display_name":"AUTONOMIC CONTROL OF LOWER URINARY TRACT FUNCTION","funder_award_id":"R01DK026508","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8586170543","display_name":"BENIGN BLADDER DISEASE AND MITOCHONDRIAL FUNCTION","funder_award_id":"R01DK047949","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W3758058","https://openalex.org/W63727678","https://openalex.org/W1038351292","https://openalex.org/W1484891484","https://openalex.org/W1552751776","https://openalex.org/W1586519380","https://openalex.org/W1599348510","https://openalex.org/W1631214209","https://openalex.org/W1798204859","https://openalex.org/W1970813153","https://openalex.org/W1979314126","https://openalex.org/W1979433005","https://openalex.org/W1980158028","https://openalex.org/W1980708476","https://openalex.org/W1981309908","https://openalex.org/W1981680619","https://openalex.org/W1993117921","https://openalex.org/W2004086480","https://openalex.org/W2011325953","https://openalex.org/W2034074655","https://openalex.org/W2046710786","https://openalex.org/W2053255482","https://openalex.org/W2061107198","https://openalex.org/W2061286597","https://openalex.org/W2085563172","https://openalex.org/W2106645381","https://openalex.org/W2153218198","https://openalex.org/W2181033881","https://openalex.org/W2186357119","https://openalex.org/W2239266442","https://openalex.org/W2366214013","https://openalex.org/W2405295577","https://openalex.org/W2409705981","https://openalex.org/W2411669679","https://openalex.org/W2432223366","https://openalex.org/W2439411988","https://openalex.org/W2485501581","https://openalex.org/W4229620005","https://openalex.org/W4298217076","https://openalex.org/W4298356947"],"related_works":["https://openalex.org/W4246107006","https://openalex.org/W2015735686","https://openalex.org/W1985015854","https://openalex.org/W2074816441","https://openalex.org/W2432223366","https://openalex.org/W1586477719","https://openalex.org/W2122488055","https://openalex.org/W1038351292","https://openalex.org/W2411669679","https://openalex.org/W3175980473"],"abstract_inverted_index":{"PURPOSE:":[0],"Experimental":[1],"studies":[2],"have":[3],"demonstrated":[4,138,258],"that":[5,45,139,224,259],"ischemia":[6,18,30,72,102,129,132,144,171],"may":[7,238],"induce":[8],"significant":[9,194],"bladder":[10,17,38,66,83,184,212,252,262],"dysfunction.":[11],"Because":[12],"multiple":[13],"causes":[14],"leading":[15],"to":[16,69,164,217,230,248,267,278],"also":[19,59,257],"decrease":[20,173,182,195],"urethral":[21,49,175],"perfusion,":[22],"we":[23],"assessed":[24],"the":[25,32,36,43,64,148,158,172,181,197,209,225,234,240,261,265,272],"effect":[26],"of":[27,35,63,81,122,143,151,170,200,244,276],"in":[28,48,70,91,108,157,162,174,183,190,196,208,215,260],"vitro":[29,71,101],"on":[31],"contractile":[33,61,176,185],"responses":[34,62,177],"rat":[37,65,82],"and":[39,67,86,95,98,119,130,160,211,242,263],"urethra.":[40],"We":[41,58,137,256],"evaluated":[42],"hypothesis":[44],"neurogenic":[46],"dysfunction":[47,55,253],"ischemic":[50,109,231],"injury":[51,232],"occurs":[52],"before":[53,128,251],"myogenic":[54],"is":[56,227,254,271],"present.":[57,255],"compared":[60],"urethra":[68,88,159,210,226,264],"followed":[73,133,145],"by":[74,105,134,146],"reoxygenation.":[75,135],"MATERIALS":[76],"AND":[77],"METHODS:":[78],"Isolated":[79],"strips":[80],"detrusor":[84],"muscle":[85],"prostatic":[87],"were":[89,125],"incubated":[90],"normal":[92],"physiological":[93],"medium":[94,110],"stimulated":[96],"electrically":[97],"chemically.":[99],"In":[100],"was":[103,178],"produced":[104],"incubating":[106],"tissue":[107],"for":[111],"30":[112,141],"or":[113],"60":[114,168,188],"minutes.":[115],"The":[116],"maximal":[117,120,149,198,206],"tension":[118,123,152,201,207],"rate":[121,150,199],"generated":[124,153,202],"analyzed":[126],"digitally":[127],"after":[131,140],"RESULTS:":[136],"minutes":[142,169,189],"reperfusion":[147],"decreased":[154],"significantly":[155],"only":[156,161,214],"response":[163,216,266],"field":[165,218,268],"stimulation.":[166,219],"After":[167],"greater":[179],"than":[180,233],"responses.":[186],"Ischemia":[187],"duration":[191],"caused":[192],"a":[193],"as":[203,205],"well":[204],"but":[213],"CONCLUSIONS:":[220],"This":[221],"experiment":[222],"demonstrates":[223],"more":[228],"sensitive":[229,274],"bladder.":[235],"Our":[236],"finding":[237],"explain":[239],"development":[241],"symptoms":[243],"urinary":[245],"incontinence":[246],"secondary":[247],"sphincteric":[249],"damage":[250],"(neurogenic)":[269],"stimulation":[270,277],"most":[273],"form":[275],"ischemia.":[279]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}