{"id":"https://openalex.org/W2033071979","doi":"https://doi.org/10.1016/j.jsgi.2003.07.007","title":"Renal Handling of Homocysteine During Normal Pregnancy and Preeclampsia","display_name":"Renal Handling of Homocysteine During Normal Pregnancy and Preeclampsia","publication_year":2003,"publication_date":"2003-12-31","ids":{"openalex":"https://openalex.org/W2033071979","doi":"https://doi.org/10.1016/j.jsgi.2003.07.007","mag":"2033071979","pmid":"https://pubmed.ncbi.nlm.nih.gov/14706683"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsgi.2003.07.007","doi":"https://doi.org/10.1016/j.jsgi.2003.07.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsgi.2003.07.007","pdf_url":null,"source":{"id":"https://openalex.org/S142156365","display_name":"Journal of the Society for Gynecologic Investigation","issn_l":"1071-5576","issn":["1071-5576","1556-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society for Gynecologic Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015633775","display_name":"Robert W. Powers","orcid":"https://orcid.org/0000-0002-7773-6433","observed_orcids":["https://orcid.org/0000-0002-7773-6433"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Powers","raw_affiliation_strings":["Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania and Cleveland Clinic Foundation, Cleveland, Ohio;","Cleveland Clinic Foundation, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania and Cleveland Clinic Foundation, Cleveland, Ohio;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I170201317","https://openalex.org/I4210097282"]},{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032855231","display_name":"Alana K. Majors","orcid":"https://orcid.org/0000-0002-3698-1838","observed_orcids":["https://orcid.org/0000-0002-3698-1838"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alana K. Majors","raw_affiliation_strings":["Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210097282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040480830","display_name":"Laurie J. Kerchner","orcid":"https://orcid.org/0000-0003-0690-5786","observed_orcids":["https://orcid.org/0000-0003-0690-5786"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie J. Kerchner","raw_affiliation_strings":["Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210097282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082749921","display_name":"Kirk P. Conrad","orcid":"https://orcid.org/0000-0003-4748-5765","observed_orcids":["https://orcid.org/0000-0003-4748-5765"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk P. Conrad","raw_affiliation_strings":["Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania and Cleveland Clinic Foundation, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magee-Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania and Cleveland Clinic Foundation, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I170201317","https://openalex.org/I4210097282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015633775"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I170201317","https://openalex.org/I4210097282"],"apc_list":null,"apc_paid":null,"fwci":4.4349,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.93475194,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"1","first_page":"45","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.984000027179718},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.734000027179718},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/plasma-homocysteine","display_name":"plasma homocysteine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.6520000100135803},{"id":"https://openalex.org/keywords/trimester-changes","display_name":"trimester changes","score":0.5270000100135803},{"id":"https://openalex.org/keywords/postpartum-period","display_name":"postpartum period","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.8577994108200073},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8167164921760559},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7927026748657227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7148442268371582},{"id":"https://openalex.org/C3017560507","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Plasma homocysteine","level":3,"score":0.6888763308525085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.656430721282959},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6331961154937744},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5225372314453125},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4860592186450958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05128410458564758},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jsgi.2003.07.007","doi":"https://doi.org/10.1016/j.jsgi.2003.07.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsgi.2003.07.007","pdf_url":null,"source":{"id":"https://openalex.org/S142156365","display_name":"Journal of the Society for Gynecologic Investigation","issn_l":"1071-5576","issn":["1071-5576","1556-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society for Gynecologic Investigation","raw_type":"journal-article"},{"id":"pmid:14706683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14706683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society for Gynecologic Investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1602458144","display_name":"Mechanisms of Preeclampsia: Impact of Obesity","funder_award_id":"P01HD030367","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G163663990","display_name":"Mechanisms of Vasodilation in Pregancy","funder_award_id":"R01DK063321","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1961531618","display_name":null,"funder_award_id":"P01 HD30367-07","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3396019356","display_name":"General Clinical Research Center","funder_award_id":"M01RR000056","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4821144202","display_name":null,"funder_award_id":"R01 DK63321-10","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4994305735","display_name":null,"funder_award_id":"R01 HD36110-02","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6083425144","display_name":"University of New Mexico - General Clinical Research Center","funder_award_id":"M01RR000997","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7135266260","display_name":"HYPERHOMOCYSTEINEMIA IN PREGNANCY AND PREECLAMPSIA","funder_award_id":"5r01hd036110-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1496821788","https://openalex.org/W1530587475","https://openalex.org/W1793327536","https://openalex.org/W1816872835","https://openalex.org/W1883798927","https://openalex.org/W1908315299","https://openalex.org/W1977349752","https://openalex.org/W1984638705","https://openalex.org/W1987685681","https://openalex.org/W1990376420","https://openalex.org/W1993449694","https://openalex.org/W1995594168","https://openalex.org/W2007672696","https://openalex.org/W2015399522","https://openalex.org/W2015517071","https://openalex.org/W2015859532","https://openalex.org/W2026754030","https://openalex.org/W2029538063","https://openalex.org/W2037946707","https://openalex.org/W2049511789","https://openalex.org/W2059746783","https://openalex.org/W2060639189","https://openalex.org/W2061921166","https://openalex.org/W2077923751","https://openalex.org/W2080773893","https://openalex.org/W2081297662","https://openalex.org/W2088562611","https://openalex.org/W2088643190","https://openalex.org/W2098374890","https://openalex.org/W2115353211","https://openalex.org/W2119348567","https://openalex.org/W2123440310","https://openalex.org/W2133645165","https://openalex.org/W2141324606","https://openalex.org/W2145083272","https://openalex.org/W2156756679","https://openalex.org/W2196504482","https://openalex.org/W2422367979","https://openalex.org/W2472091358","https://openalex.org/W4232522257","https://openalex.org/W4246134835"],"related_works":["https://openalex.org/W1985935048","https://openalex.org/W1898444179","https://openalex.org/W3010332730","https://openalex.org/W2015517071","https://openalex.org/W7098118626","https://openalex.org/W2115166939","https://openalex.org/W2337781154","https://openalex.org/W7218105672","https://openalex.org/W7132580049","https://openalex.org/W2008783534"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}