{"id":"https://openalex.org/W2033033734","doi":"https://doi.org/10.1186/ar4389","title":"Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity","display_name":"Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity","publication_year":2013,"publication_date":"2013-11-25","ids":{"openalex":"https://openalex.org/W2033033734","doi":"https://doi.org/10.1186/ar4389","mag":"2033033734","pmid":"https://pubmed.ncbi.nlm.nih.gov/24267267","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978471"},"language":"en","primary_location":{"id":"doi:10.1186/ar4389","doi":"https://doi.org/10.1186/ar4389","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar4389","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4389","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060640169","display_name":"John M. Davis","orcid":"https://orcid.org/0000-0002-9710-8143","observed_orcids":["https://orcid.org/0000-0002-9710-8143"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M Davis","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I4210131476","display_name":"Vaccine & Gene Therapy Institute of Florida","ror":"https://ror.org/03ez2en98","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210131476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith L Knutson","raw_affiliation_strings":["Cancer Vaccine and Immune Therapies Program, Vaccine & Gene Therapy Institute of Florida, 9801 S.W. Discovery Way, Port Saint Lucie, FL, 34987, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Vaccine and Immune Therapies Program, Vaccine & Gene Therapy Institute of Florida, 9801 S.W. Discovery Way, Port Saint Lucie, FL, 34987, USA","institution_ids":["https://openalex.org/I4210131476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011647544","display_name":"Michael A. Strausbauch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Strausbauch","raw_affiliation_strings":["Department of Surgical Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063143134","display_name":"Abigail B. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail B Green","raw_affiliation_strings":["Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091454890","display_name":"Cynthia S. Crowson","orcid":"https://orcid.org/0000-0001-5847-7475","observed_orcids":["https://orcid.org/0000-0001-5847-7475"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia S Crowson","raw_affiliation_strings":["Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014433885","display_name":"Terry M. Therneau","orcid":"https://orcid.org/0000-0003-1490-6711","observed_orcids":["https://orcid.org/0000-0003-1490-6711"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry M Therneau","raw_affiliation_strings":["Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052273654","display_name":"Eric L. Matteson","orcid":"https://orcid.org/0000-0002-9866-0124","observed_orcids":["https://orcid.org/0000-0002-9866-0124"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L Matteson","raw_affiliation_strings":["Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106342090","display_name":"Sherine E. Gabriel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherine E Gabriel","raw_affiliation_strings":["Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060640169"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":1.6379,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82518654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"6","first_page":"R199","last_page":"R199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.949999988079071},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7570000290870667},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":1.0},{"id":"https://openalex.org/keywords/t-cell-cytokines","display_name":"T cell cytokines","score":0.7799999713897705},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9169999957084656},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.8679999709129333},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.45100000500679016},{"id":"https://openalex.org/keywords/cmv-igg","display_name":"CMV IgG","score":0.5799999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.722000002861023},{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8649762272834778},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7859811782836914},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6715025305747986},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.6477146148681641},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6127899289131165},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.508398711681366},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4800509214401245},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.42361822724342346}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/ar4389","doi":"https://doi.org/10.1186/ar4389","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar4389","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4389","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2961091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3978471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:24267267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24267267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/ar4389","doi":"https://doi.org/10.1186/ar4389","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar4389","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4389","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1249096266","display_name":null,"funder_award_id":"RR-024150","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3825399106","display_name":"Mayo Clinic Center for Translational Science Activities","funder_award_id":"KL2RR024151","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G496563027","display_name":null,"funder_award_id":"RR024151","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5671986908","display_name":null,"funder_award_id":"UL1 RR024150","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G6078569299","display_name":null,"funder_award_id":"UL1 RR024150","funder_id":"https://openalex.org/F4320309464","funder_display_name":"Mayo Foundation for Medical Education and Research"},{"id":"https://openalex.org/G8875974309","display_name":"Mayo Clinic Center for Translational Science Activities","funder_award_id":"UL1RR024150","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000025438","display_name":null,"funder_award_id":"RR024150","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306237","display_name":"Arthritis Foundation","ror":"https://ror.org/04zk9fe75"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033033734.pdf","grobid_xml":"https://content.openalex.org/works/W2033033734.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W45832520","https://openalex.org/W46420290","https://openalex.org/W67343583","https://openalex.org/W1483140880","https://openalex.org/W1500489979","https://openalex.org/W1500526256","https://openalex.org/W1584371093","https://openalex.org/W1984792692","https://openalex.org/W1985004174","https://openalex.org/W1988660834","https://openalex.org/W2000832741","https://openalex.org/W2009098629","https://openalex.org/W2011649071","https://openalex.org/W2032169254","https://openalex.org/W2034332027","https://openalex.org/W2052219721","https://openalex.org/W2053663054","https://openalex.org/W2054343352","https://openalex.org/W2059074535","https://openalex.org/W2085192536","https://openalex.org/W2088808688","https://openalex.org/W2092829005","https://openalex.org/W2101832744","https://openalex.org/W2102096947","https://openalex.org/W2109237866","https://openalex.org/W2110177517","https://openalex.org/W2116314748","https://openalex.org/W2117738981","https://openalex.org/W2127532898","https://openalex.org/W2136624067","https://openalex.org/W2140249125","https://openalex.org/W2141217635","https://openalex.org/W2142165059","https://openalex.org/W2142328050","https://openalex.org/W2147798113","https://openalex.org/W2155109530","https://openalex.org/W2156712409","https://openalex.org/W2160097074","https://openalex.org/W2167939282","https://openalex.org/W2168547915","https://openalex.org/W2169772272","https://openalex.org/W2171364167","https://openalex.org/W2171953655"],"related_works":["https://openalex.org/W4242790635","https://openalex.org/W2141217635","https://openalex.org/W2101832744","https://openalex.org/W2198144447","https://openalex.org/W7160309690","https://openalex.org/W2981986693","https://openalex.org/W3083830923","https://openalex.org/W2920823803","https://openalex.org/W4411396741","https://openalex.org/W4379523054"],"abstract_inverted_index":{"INTRODUCTION:":[0],"It":[1],"remains":[2],"challenging":[3],"to":[4,22,63,129,161,165,172,230,242,294,311],"predict":[5],"the":[6,71,125,136,168,180,223,245,259,268,308],"outcomes":[7,32,347],"of":[8,18,40,66,97,102,143,148,179,258,267,300,348],"therapy":[9,313],"in":[10,33,75,135,159,314,333],"patients":[11,34,43,216,238,315],"with":[12,29,35,44,49,94,124,167,265,276,304,316,324],"rheumatoid":[13],"arthritis":[14],"(RA).":[15],"The":[16,198,271],"objective":[17],"this":[19,290],"study":[20],"was":[21,54,68,82,138,163,202,263,274,292],"identify":[23],"immune":[24,182],"response":[25,80,160,183,201,291,310,343],"signatures":[26],"that":[27,331],"correlate":[28,166],"clinical":[30,309],"treatment":[31,48,342],"RA.":[36,318,349],"METHODS:":[37],"A":[38,131,146,298],"cohort":[39],"71":[41],"consecutive":[42],"early":[45,317],"RA":[46],"starting":[47],"disease-modifying":[50],"antirheumatic":[51],"drugs":[52],"(DMARDs)":[53],"recruited.":[55],"Disease":[56,72],"activity":[57],"at":[58],"baseline":[59,128,171,199,229],"and":[60,106,156,210,344],"after":[61],"21":[62],"24":[64],"weeks":[65],"follow-up":[67,231],"measured":[69],"using":[70],"Activity":[73],"Score":[74],"28":[76],"joints":[77],"(DAS28).":[78],"Immune":[79],"profiling":[81],"performed":[83],"by":[84,205,337],"analyzing":[85],"multi-cytokine":[86],"production":[87],"from":[88,127,170,228],"peripheral":[89],"blood":[90],"cells":[91],"following":[92],"incubation":[93],"a":[95,100,141,176],"panel":[96],"stimuli,":[98],"including":[99],"mixture":[101],"human":[103],"cytomegalovirus":[104],"(CMV)":[105],"Epstein-Barr":[107],"virus":[108],"(EBV)":[109],"lysates.":[110],"Profiles":[111],"identified":[112],"via":[113],"principal":[114],"components":[115],"analysis":[116],"(PCA)":[117],"for":[118],"each":[119],"stimulus":[120],"were":[121],"then":[122],"correlated":[123],"\u0394DAS28":[126,169],"follow-up.":[130,173],"clinically":[132,219],"meaningful":[133,220],"improvement":[134,188],"DAS28":[137,187,221],"defined":[139],"as":[140],"decrease":[142],"\u22651.2.":[144],"RESULTS:":[145],"profile":[147,184,273,299],"T-cell":[149,301,334],"cytokines":[150],"(IL-13,":[151],"IL-4,":[152],"IL-5,":[153],"IL-2,":[154],"IL-12,":[155],"IFN-\u03b3)":[157],"produced":[158],"CMV/EBV":[162,181,200,224,246,269,272],"found":[164],"At":[174],"baseline,":[175],"higher":[177],"magnitude":[178],"predicted":[185],"inadequate":[186],"(mean":[189,232,250],"PCA-1":[190,225,247],"scores:":[191],"65.6":[192],"versus":[193],"50.2;":[194],"P":[195,254],"=":[196,208,213,255,287],"0.029).":[197],"particularly":[203],"driven":[204],"IFN-\u03b3":[206],"(P":[207,212,280,286],"0.039)":[209],"IL-4":[211],"0.027).":[214],"Among":[215],"who":[217,239],"attained":[218],"improvement,":[222],"score":[226,248],"increased":[227],"+11.6,":[233],"SD":[234,252],"25.5),":[235],"whereas":[236],"among":[237],"responded":[240],"inadequately":[241],"DMARD":[243,312],"therapy,":[244],"decreased":[249],"-12.8,":[251],"25.4;":[253],"0.002).":[256],"Irrespective":[257],"\u0394DAS28,":[260],"methotrexate":[261],"use":[262],"associated":[264,275,303,323],"up-regulation":[266],"response.":[270],"positive":[277],"CMV":[278,295,305,320],"IgG":[279,285],"<0.001),":[281],"but":[282],"not":[283],"EBV":[284],"0.32),":[288],"suggesting":[289],"related":[293],"exposure.":[296],"CONCLUSIONS:":[297],"immunity":[302,335],"exposure":[306],"influences":[307],"Because":[319],"latency":[321],"is":[322],"greater":[325],"joint":[326],"destruction,":[327],"our":[328],"findings":[329],"suggest":[330],"changes":[332],"mediated":[336],"viral":[338],"persistence":[339],"may":[340],"affect":[341],"possibly":[345],"long-term":[346]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
