{"id":"https://openalex.org/W2033014787","doi":"https://doi.org/10.1021/bi00368a018","title":"Effects of bovine pancreatic ribonuclease A, S protein, and S peptide on activation of purified rat hepatic glucocorticoid-receptor complexes","display_name":"Effects of bovine pancreatic ribonuclease A, S protein, and S peptide on activation of purified rat hepatic glucocorticoid-receptor complexes","publication_year":1986,"publication_date":"1986-10-07","ids":{"openalex":"https://openalex.org/W2033014787","doi":"https://doi.org/10.1021/bi00368a018","mag":"2033014787","pmid":"https://pubmed.ncbi.nlm.nih.gov/3790497"},"language":"en","primary_location":{"id":"doi:10.1021/bi00368a018","doi":"https://doi.org/10.1021/bi00368a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00368a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101825199","display_name":"Thomas J. Schmidt","orcid":"https://orcid.org/0000-0002-6792-9426","observed_orcids":["https://orcid.org/0000-0002-6792-9426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023224078","display_name":"Edward E. Diehl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. E. Diehl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105502167","display_name":"Catherine Joan Davidson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. J. Davidson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050274797","display_name":"Michael J. Puk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Puk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081283097","display_name":"Maria L. Webb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. L. Webb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald Litwack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.5518,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.92890356,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"20","first_page":"5955","last_page":"5961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-a","display_name":"ribonuclease A","score":0.890999972820282},{"id":"https://openalex.org/keywords/s-protein","display_name":"S protein","score":0.824999988079071},{"id":"https://openalex.org/keywords/s-peptide","display_name":"S-peptide","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8650000095367432},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/rna-binding-sites","display_name":"RNA binding sites","score":0.6970000267028809},{"id":"https://openalex.org/keywords/dna-cellulose-binding","display_name":"DNA-cellulose binding","score":0.7649999856948853},{"id":"https://openalex.org/keywords/receptor-conformational-change","display_name":"receptor conformational change","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.7405399084091187},{"id":"https://openalex.org/C2776813977","wikidata":"https://www.wikidata.org/wiki/Q2711884","display_name":"Bovine pancreatic ribonuclease","level":5,"score":0.7300777435302734},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.6434378027915955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6283621788024902},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5295696258544922},{"id":"https://openalex.org/C2780704907","wikidata":"https://www.wikidata.org/wiki/Q87195451","display_name":"Pancreatic ribonuclease","level":5,"score":0.5156089663505554},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5056896209716797},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47472083568573},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4654475152492523},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.45977509021759033},{"id":"https://openalex.org/C79750893","wikidata":"https://www.wikidata.org/wiki/Q3430180","display_name":"Ribonuclease III","level":5,"score":0.43421271443367004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4338865876197815},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.43200746178627014},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.43065235018730164},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39560040831565857},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37611234188079834},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2699412703514099},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00368a018","doi":"https://doi.org/10.1021/bi00368a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00368a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:3790497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3790497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2308377387","display_name":"ACTIVATION OF PURIFIED GLUCOCORTICOID-RECEPTOR COMPLEXES","funder_award_id":"5r01am034490-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5348570785","display_name":"PROPERTIES OF THE PURIFIED GLUOCOCORTICOID RECEPTOR","funder_award_id":"5r01am032870-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8272410754","display_name":"METABOLISM OF CORTISOL IN LIVER","funder_award_id":"5r01am013531-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W51337561","https://openalex.org/W143488173","https://openalex.org/W971986293","https://openalex.org/W1516283219","https://openalex.org/W1534815799","https://openalex.org/W1537264614","https://openalex.org/W1541332557","https://openalex.org/W1568015334","https://openalex.org/W1573615384","https://openalex.org/W1574229173","https://openalex.org/W1896307881","https://openalex.org/W1954288537","https://openalex.org/W1969197892","https://openalex.org/W1973154187","https://openalex.org/W1973798024","https://openalex.org/W1985313279","https://openalex.org/W1986106014","https://openalex.org/W1990080937","https://openalex.org/W2001656715","https://openalex.org/W2003328443","https://openalex.org/W2004376767","https://openalex.org/W2005996033","https://openalex.org/W2013090048","https://openalex.org/W2014139892","https://openalex.org/W2014346038","https://openalex.org/W2018531293","https://openalex.org/W2018632980","https://openalex.org/W2021651508","https://openalex.org/W2024098392","https://openalex.org/W2024745769","https://openalex.org/W2044623552","https://openalex.org/W2050586961","https://openalex.org/W2060389418","https://openalex.org/W2063795328","https://openalex.org/W2069212278","https://openalex.org/W2083263961","https://openalex.org/W2085134421","https://openalex.org/W2089250490","https://openalex.org/W2103185902","https://openalex.org/W2148008715","https://openalex.org/W2165819379","https://openalex.org/W2342073136"],"related_works":["https://openalex.org/W2050586961","https://openalex.org/W1817751043","https://openalex.org/W2151624252","https://openalex.org/W2018531293","https://openalex.org/W1979286967","https://openalex.org/W2074076851","https://openalex.org/W2069341296","https://openalex.org/W2342265918","https://openalex.org/W2024125488","https://openalex.org/W2012709040"],"abstract_inverted_index":{"Bovine":[0],"pancreatic":[1],"ribonuclease":[2],"(RNase)":[3],"A":[4,14,59,110,199],"and":[5,60,111,125,158,200],"S":[6,61,86,112,201,222],"protein":[7,62,113,202],"(enzymatically":[8,88],"inactive":[9,89],"proteolytic":[10,90],"fragment":[11,91],"of":[12,29,44,55,81,135,163,175,197,216,228,236],"RNase":[13,56,58,109,198,205],"which":[15,92,120,169],"contains":[16],"RNA":[17,94,211,218],"binding":[18,46,67,80,95,104,156,219,235],"site)":[19,96],"stimulate":[20,116,233],"the":[21,117,132,161,217,225,237],"activation,":[22],"as":[23],"evidenced":[24],"by":[25],"increasing":[26],"DNA-cellulose":[27,45,66,155,234],"binding,":[28],"highly":[30],"purified":[31,238],"rat":[32],"hepatic":[33],"glucocorticoid-receptor":[34],"complexes.":[35],"These":[36],"effects":[37,162],"are":[38],"dose":[39],"dependent":[40],"with":[41,74,123,146],"maximal":[42],"stimulation":[43],"being":[47],"detected":[48],"at":[49],"approximately":[50],"500":[51],"micrograms":[52],"(50":[53],"units":[54],"A/mL).":[57],"do":[63,114],"not":[64,115],"enhance":[65,153],"via":[68],"their":[69,154],"ability":[70,227],"to":[71,77,83,151,203,232],"interact":[72,145],"directly":[73],"DNA":[75,103],"or":[76,213],"increase":[78],"nonspecific":[79,101],"receptors":[82],"cellulose.":[84],"Neither":[85],"peptide":[87],"lacks":[93],"nor":[97],"cytochrome":[98],"c,":[99],"a":[100,129],"basic":[102],"protein,":[105,223],"mimics":[106],"these":[107,142,229],"effects.":[108],"conformational":[118],"change":[119],"is":[121,126],"associated":[122],"activation":[124,178],"reflected":[127],"in":[128,131,176],"shift":[130],"elution":[133],"profile":[134],"receptor":[136,149],"complexes":[137,150],"from":[138],"DEAE-cellulose.":[139],"In":[140],"contrast,":[141],"two":[143,230],"proteins":[144,231],"previously":[147],"heat-activated":[148],"further":[152],"capacity":[157],"thus":[159],"mimic":[160],"an":[164,204,209],"endogenous":[165],"heat-stable":[166],"cytoplasmic":[167],"protein(s)":[168],"also":[170],"function(s)":[171],"during":[172],"step":[173],"2":[174],"vitro":[177],"[Schmidt,":[179],"T.":[180],"J.,":[181],"Miller-Diener,":[182],"A.,":[183],"Webb,":[184],"M.":[185],"L.,":[186],"&":[187],"Litwack,":[188],"G.":[189],"(1985)":[190],"J.":[191],"Biol.":[192],"Chem.":[193],"260,":[194],"16255-16262].":[195],"Preadsorption":[196],"affinity":[206],"resin":[207],"containing":[208],"inhibitory":[210],"analogue,":[212],"trypsin":[214],"digestion":[215],"site":[220],"within":[221],"eliminates":[224],"subsequent":[226],"receptors.(ABSTRACT":[239],"TRUNCATED":[240],"AT":[241],"250":[242],"WORDS)":[243]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
