{"id":"https://openalex.org/W2032916625","doi":"https://doi.org/10.1097/aln.0b013e31818958f7","title":"Capsaicin Combined with Local Anesthetics Preferentially Prolongs Sensory/Nociceptive Block in Rat Sciatic Nerve","display_name":"Capsaicin Combined with Local Anesthetics Preferentially Prolongs Sensory/Nociceptive Block in Rat Sciatic Nerve","publication_year":2008,"publication_date":"2008-10-17","ids":{"openalex":"https://openalex.org/W2032916625","doi":"https://doi.org/10.1097/aln.0b013e31818958f7","mag":"2032916625","pmid":"https://pubmed.ncbi.nlm.nih.gov/18946300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2635105"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0b013e31818958f7","doi":"https://doi.org/10.1097/aln.0b013e31818958f7","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31818958f7","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/109/5/872/533215/0000542-200811000-00021.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/109/5/872/533215/0000542-200811000-00021.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106749775","display_name":"Peter Gerner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter Gerner","raw_affiliation_strings":["Assistant Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008824228","display_name":"Alexander M. Binshtok","orcid":"https://orcid.org/0000-0002-3620-8116","observed_orcids":["https://orcid.org/0000-0002-3620-8116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander\u00a0M. Binshtok","raw_affiliation_strings":["Instructor in Anesthesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instructor in Anesthesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113559559","display_name":"Chi-Fei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Fei Wang","raw_affiliation_strings":["Research Fellow, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Fellow, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083706094","display_name":"Nathanael D. Hevelone","orcid":"https://orcid.org/0000-0003-4740-2085","observed_orcids":["https://orcid.org/0000-0003-4740-2085"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathanael\u00a0D. Hevelone","raw_affiliation_strings":["Biostatistician, Center for Outcomes and Policy Research, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistician, Center for Outcomes and Policy Research, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087690593","display_name":"Bruce P. Bean","orcid":"https://orcid.org/0000-0002-5093-3576","observed_orcids":["https://orcid.org/0000-0002-5093-3576"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce\u00a0P. Bean","raw_affiliation_strings":["Professor, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017534594","display_name":"Clifford J. Woolf","orcid":"https://orcid.org/0000-0002-6636-3897","observed_orcids":["https://orcid.org/0000-0002-6636-3897","https://orcid.org/0000-0001-9840-596X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford\u00a0J. Woolf","raw_affiliation_strings":["Professor, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111686367","display_name":"Ging Kuo Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ging\u00a0Kuo Wang","raw_affiliation_strings":["Associate Professor, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5106749775"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.915,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.97636727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"109","issue":"5","first_page":"872","last_page":"878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.4553000032901764,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.4553000032901764,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.34299999475479126,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.984000027179718},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.5220000147819519},{"id":"https://openalex.org/keywords/sensory-block","display_name":"sensory block","score":0.7860000133514404},{"id":"https://openalex.org/keywords/sciatic-nerve-block","display_name":"sciatic nerve block","score":0.8259999752044678},{"id":"https://openalex.org/keywords/c-fiber-nociceptors","display_name":"C-fiber nociceptors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.75},{"id":"https://openalex.org/keywords/bupivacaine","display_name":"bupivacaine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.9729999899864197},{"id":"https://openalex.org/keywords/qx-314","display_name":"QX-314","score":0.9359999895095825},{"id":"https://openalex.org/keywords/regional-analgesia","display_name":"regional analgesia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/engine-block","display_name":"motor block","score":0.4259999990463257},{"id":"https://openalex.org/keywords/cutaneous-pain","display_name":"skin pain","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.7825682163238525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.718936562538147},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6903878450393677},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6854019165039062},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.6379789113998413},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.5574042201042175},{"id":"https://openalex.org/C2778994108","wikidata":"https://www.wikidata.org/wiki/Q1868462","display_name":"Local anesthetic","level":2,"score":0.5316342115402222},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.4716804623603821},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.4358755052089691},{"id":"https://openalex.org/C2778843932","wikidata":"https://www.wikidata.org/wiki/Q2018262","display_name":"Axon reflex","level":3,"score":0.41125425696372986},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37651723623275757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16087019443511963},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11340951919555664}],"mesh":[{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/aln.0b013e31818958f7","doi":"https://doi.org/10.1097/aln.0b013e31818958f7","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31818958f7","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/109/5/872/533215/0000542-200811000-00021.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:18946300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18946300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:1940778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2635105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2635105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2635105","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anesthesiology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/aln.0b013e31818958f7","doi":"https://doi.org/10.1097/aln.0b013e31818958f7","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31818958f7","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/109/5/872/533215/0000542-200811000-00021.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8051586633","display_name":"Neural Plasticity and Inflammatory Pain","funder_award_id":"R01NS039518","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8432501042","display_name":"Therapeutic Na+ channel blockers: Receptor & Drug Design","funder_award_id":"R01GM048090","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032916625.pdf","grobid_xml":"https://content.openalex.org/works/W2032916625.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1964535559","https://openalex.org/W1967776969","https://openalex.org/W1973867835","https://openalex.org/W1991018296","https://openalex.org/W2002262769","https://openalex.org/W2003706636","https://openalex.org/W2018143015","https://openalex.org/W2026049097","https://openalex.org/W2032034626","https://openalex.org/W2032615110","https://openalex.org/W2042964029","https://openalex.org/W2045592577","https://openalex.org/W2047711606","https://openalex.org/W2058672163","https://openalex.org/W2059229640","https://openalex.org/W2062244718","https://openalex.org/W2072749656","https://openalex.org/W2083777441","https://openalex.org/W2107705149","https://openalex.org/W2115052737","https://openalex.org/W2116411564","https://openalex.org/W2124141753","https://openalex.org/W2128265835","https://openalex.org/W2150142099","https://openalex.org/W2157761983","https://openalex.org/W2166828796","https://openalex.org/W2168210103","https://openalex.org/W2765629363","https://openalex.org/W4248805815"],"related_works":["https://openalex.org/W2161006864","https://openalex.org/W1997859557","https://openalex.org/W2033282146","https://openalex.org/W1987002741","https://openalex.org/W1986271490","https://openalex.org/W7098568646","https://openalex.org/W2137549976","https://openalex.org/W2069143094","https://openalex.org/W2168210103","https://openalex.org/W2073474277"],"abstract_inverted_index":{"BACKGROUND:":[0],"Transient":[1],"receptor":[2,33,235],"potential":[3,34,236],"vanilloid":[4,35,237],"1":[5,36,238],"channels":[6],"integrate":[7],"nociceptive":[8],"stimuli":[9],"and":[10,99,142,212,241],"are":[11],"predominantly":[12,179,220],"expressed":[13],"by":[14,129,137,145,169,226],"unmyelinated":[15],"C-fiber":[16],"nociceptors,":[17],"but":[18],"not":[19,193],"low-threshold":[20],"mechanoreceptive":[21],"sensory":[22],"or":[23,74,78,108,112,166,245],"motor":[24,55],"fibers.":[25],"A":[26],"recent":[27],"report":[28],"showed":[29],"that":[30],"the":[31,118,122,130,138,152,201],"transient":[32,234],"channel":[37,239],"agonist":[38],"capsaicin":[39,110,172,191],"allows":[40],"a":[41,61,84,148,158,178,195,219,256],"hydrophilic":[42],"quaternary":[43,214,247],"ammonium":[44,215,248],"derivative":[45],"of":[46,102,147,171,186,203,228,233],"lidocaine,":[47,75,167],"QX-314,":[48],"to":[49,117,254],"selectively":[50],"block":[51,64,88,223,259],"C":[52],"fibers":[53],"without":[54],"block.":[56],"The":[57,230],"authors":[58],"tested":[59],"whether":[60],"similar":[62],"differential":[63,198,258],"would":[65],"be":[66],"produced":[67],"using":[68],"amphipathic":[69],"N-methyl":[70,204],"amitriptyline,":[71,72,163,164],"bupivacaine,":[73,165],"either":[76,106],"alone":[77,107],"together":[79],"with":[80,97,109,157,190,200],"0.05%":[81],"capsaicin,":[82],"in":[83,121,260],"rat":[85],"sciatic":[86,119,123],"nerve":[87,120],"model.":[89],"METHODS:":[90],"Rats":[91],"(n":[92],"=":[93],"8/group)":[94],"were":[95],"anesthetized":[96],"sevoflurane,":[98],"0.2":[100],"ml":[101],"drug":[103],"was":[104,127,135],"injected":[105],"(simultaneously":[111],"10":[113,173],"min":[114,174],"later)":[115],"next":[116],"notch.":[124],"Motor":[125],"function":[126],"assessed":[128],"extensor":[131],"postural":[132],"thrust.":[133],"Nociception":[134],"evaluated":[136],"nocifensive":[139],"withdrawal":[140],"reflex":[141],"vocalization":[143],"evoked":[144],"pinch":[146],"skin":[149],"fold":[150],"over":[151],"lateral":[153],"metatarsus":[154],"(cutaneous":[155],"pain)":[156],"serrated":[159],"forceps.":[160],"RESULTS:":[161],"N-Methyl":[162],"followed":[168,225],"injection":[170,227],"later,":[175],"each":[176,187],"elicited":[177],"nociceptive-specific":[180],"blockade.":[181],"In":[182],"comparison,":[183],"simultaneous":[184],"application":[185,232],"local":[188,210,243],"anesthetic":[189],"did":[192],"elicit":[194,218],"clinically":[196],"significant":[197],"block,":[199],"exception":[202],"amitriptyline.":[205],"CONCLUSIONS:":[206],"Both":[207],"tertiary":[208],"amine":[209],"anesthetics":[211,244],"their":[213,246],"derivatives":[216,249],"can":[217],"sensory/nociceptor":[221],"selective":[222],"when":[224],"capsaicin.":[229],"combined":[231],"agonists":[240],"various":[242],"is":[250],"an":[251],"appealing":[252],"strategy":[253],"achieve":[255],"long-lasting":[257],"regional":[261],"analgesia.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
