{"id":"https://openalex.org/W2032893017","doi":"https://doi.org/10.1093/nar/gkp1053","title":"Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase","display_name":"Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase","publication_year":2009,"publication_date":"2009-11-26","ids":{"openalex":"https://openalex.org/W2032893017","doi":"https://doi.org/10.1093/nar/gkp1053","mag":"2032893017","pmid":"https://pubmed.ncbi.nlm.nih.gov/19942682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831299"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkp1053","doi":"https://doi.org/10.1093/nar/gkp1053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkp1053","pdf_url":"https://academic.oup.com/nar/article-pdf/38/4/1401/11219075/gkp1053.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/38/4/1401/11219075/gkp1053.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111728265","display_name":"Xianchi Dong","orcid":"https://orcid.org/0000-0002-7599-8704","observed_orcids":["https://orcid.org/0000-0002-7599-8704","https://orcid.org/0009-0000-4244-6703"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Xianchi Dong","raw_affiliation_strings":["State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101267719","display_name":"Minyun Zhou","orcid":"https://orcid.org/0009-0002-4903-3818","observed_orcids":["https://orcid.org/0009-0002-4903-3818"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Minyun Zhou","raw_affiliation_strings":["State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101622975","display_name":"Chen Zhong","orcid":"https://orcid.org/0000-0003-2794-3247","observed_orcids":["https://orcid.org/0000-0003-2794-3247"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Chen Zhong","raw_affiliation_strings":["State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044040961","display_name":"Bei Yang","orcid":"https://orcid.org/0000-0001-5389-3859","observed_orcids":["https://orcid.org/0000-0001-5389-3859"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Bei Yang","raw_affiliation_strings":["State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ning Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Ning Shen","raw_affiliation_strings":["State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112512641","display_name":"Jianping Ding","orcid":"https://orcid.org/0000-0001-7029-7346","observed_orcids":["https://orcid.org/0000-0001-7029-7346"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Jianping Ding","raw_affiliation_strings":["State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and 2 Graduate School of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5112512641"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.5494,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.60337661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"38","issue":"4","first_page":"1401","last_page":"1412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophanyl-trna-synthetase","display_name":"tryptophanyl-tRNA synthetase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tyrosyl-trna-synthetase","display_name":"tyrosyl-tRNA synthetase","score":0.906000018119812},{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pyrococcus-horikoshii","display_name":"Pyrococcus horikoshii","score":0.9750000238418579},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/enzyme-evolution","display_name":"enzyme evolution","score":0.5640000104904175},{"id":"https://openalex.org/keywords/archaea","display_name":"archaea","score":0.4449999928474426},{"id":"https://openalex.org/keywords/eukaryotes","display_name":"eukaryotes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/bacteria","display_name":"bacteria","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8189729452133179},{"id":"https://openalex.org/C2778332380","wikidata":"https://www.wikidata.org/wiki/Q16988922","display_name":"Pyrococcus horikoshii","level":3,"score":0.7915335893630981},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.6191920042037964},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.6143564581871033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.598357081413269},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5833832025527954},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5653111934661865},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.45800045132637024},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.44265416264533997},{"id":"https://openalex.org/C2778644216","wikidata":"https://www.wikidata.org/wiki/Q1209791","display_name":"Sulfolobus","level":4,"score":0.4143609404563904},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4093679189682007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24663028120994568},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17381030321121216},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16169953346252441},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1537933647632599}],"mesh":[{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014369","descriptor_name":"Tryptophan-tRNA Ligase","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D014369","descriptor_name":"Tryptophan-tRNA Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014369","descriptor_name":"Tryptophan-tRNA Ligase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D043902","descriptor_name":"Pyrococcus horikoshii","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkp1053","doi":"https://doi.org/10.1093/nar/gkp1053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkp1053","pdf_url":"https://academic.oup.com/nar/article-pdf/38/4/1401/11219075/gkp1053.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2831299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:19942682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19942682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkp1053","doi":"https://doi.org/10.1093/nar/gkp1053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkp1053","pdf_url":"https://academic.oup.com/nar/article-pdf/38/4/1401/11219075/gkp1053.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1437135485","display_name":null,"funder_award_id":"KSCX2-YW-R-107","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G2743590090","display_name":null,"funder_award_id":"SIBS2008002","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G4757331301","display_name":null,"funder_award_id":"KSCX2-YW-R","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5662444892","display_name":"\u53c2\u4e0e\u7ec4\u86cb\u767d\u4fee\u9970\u7684\u91cd\u8981\u86cb\u767d\u8d28\u548c\u86cb\u767d\u8d28\u590d\u5408\u7269\u7684\u7ed3\u6784\u4e0e\u529f\u80fd\u7814\u7a76","funder_award_id":"30730028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8037757793","display_name":null,"funder_award_id":"07XD14032","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G8605382343","display_name":"\u8272\u6c28\u9170-tRNA\u5408\u6210\u9176\u5bb6\u65cf\u7684\u50ac\u5316\u673a\u7406\u548c\u8fdb\u5316\u5173\u7cfb\u7684\u7814\u7a76","funder_award_id":"30770480","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032893017.pdf","grobid_xml":"https://content.openalex.org/works/W2032893017.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1480595868","https://openalex.org/W1508885706","https://openalex.org/W1539796472","https://openalex.org/W1597579284","https://openalex.org/W1951639553","https://openalex.org/W1967131638","https://openalex.org/W1967856778","https://openalex.org/W1972485008","https://openalex.org/W1973713209","https://openalex.org/W1974487113","https://openalex.org/W1977720326","https://openalex.org/W1981529363","https://openalex.org/W1985629904","https://openalex.org/W1995017064","https://openalex.org/W1998502755","https://openalex.org/W2001641653","https://openalex.org/W2006817523","https://openalex.org/W2008925650","https://openalex.org/W2013083986","https://openalex.org/W2015878082","https://openalex.org/W2018756788","https://openalex.org/W2029667189","https://openalex.org/W2038840577","https://openalex.org/W2044385639","https://openalex.org/W2051659829","https://openalex.org/W2052537416","https://openalex.org/W2054766951","https://openalex.org/W2058798560","https://openalex.org/W2068748726","https://openalex.org/W2083061913","https://openalex.org/W2094389087","https://openalex.org/W2100999725","https://openalex.org/W2101220662","https://openalex.org/W2111038162","https://openalex.org/W2125121305","https://openalex.org/W2129682645","https://openalex.org/W2130404197","https://openalex.org/W2130940389","https://openalex.org/W2132049191","https://openalex.org/W2134201060","https://openalex.org/W2140885472","https://openalex.org/W2144081223","https://openalex.org/W2144234841","https://openalex.org/W2148345062","https://openalex.org/W2148560957","https://openalex.org/W2148792677","https://openalex.org/W2164753093","https://openalex.org/W2167832495","https://openalex.org/W6661216860","https://openalex.org/W7018033056"],"related_works":["https://openalex.org/W2068748726","https://openalex.org/W2591043444","https://openalex.org/W2107864048","https://openalex.org/W2129538546","https://openalex.org/W2069791941","https://openalex.org/W2052537416","https://openalex.org/W2255723616","https://openalex.org/W2038341182","https://openalex.org/W2000215177","https://openalex.org/W1977315391"],"abstract_inverted_index":{"The":[0],"ancient":[1],"and":[2,23,27,33,105,147,171,174,178,194],"ubiquitous":[3],"aminoacyl-tRNA":[4],"synthetases":[5],"constitute":[6],"a":[7,43,97,124],"valuable":[8],"model":[9],"system":[10],"for":[11,49,108],"studying":[12],"early":[13,201],"evolutionary":[14,19,126],"events.":[15],"So":[16],"far,":[17],"the":[18,53,58,66,92,109,131,148,154,160,166,183,190],"relationship":[20],"of":[21,52,62,68,103,118,150,157,163,186,192,203],"tryptophanyl-":[22],"tyrosyl-tRNA":[24],"synthetase":[25],"(TrpRS":[26],"TyrRS)":[28],"remains":[29],"controversial.":[30],"As":[31],"TrpRS":[32,71,104,151,170,193],"TyrRS":[34,173],"share":[35],"low":[36],"sequence":[37],"homology":[38],"but":[39],"high":[40],"structural":[41],"similarity,":[42],"structure-based":[44,100],"method":[45],"would":[46],"be":[47],"advantageous":[48],"phylogenetic":[50,101,133],"analysis":[51],"enzymes.":[54],"Here,":[55],"we":[56,95],"present":[57],"first":[59,110],"crystal":[60],"structure":[61,67],"an":[63],"archaeal":[64,155,161,172,179],"TrpRS,":[65,180,187],"Pyrococcus":[69],"horikoshii":[70],"(pTrpRS)":[72],"in":[73,130,153],"complex":[74],"with":[75,140,182],"tryptophanyl-5'":[76],"AMP":[77],"(TrpAMP)":[78],"at":[79,200],"3.0":[80],"A":[81],"resolution":[82],"which":[83,107],"demonstrates":[84],"more":[85,98],"similarities":[86],"to":[87],"its":[88],"eukaryotic":[89],"counterparts.":[90],"With":[91],"pTrpRS":[93],"structure,":[94],"perform":[96],"complete":[99],"study":[102],"TyrRS,":[106,158],"time":[111],"includes":[112],"representatives":[113],"from":[114,137],"all":[115],"three":[116],"domains":[117],"life.":[119],"Individually,":[120],"each":[121],"enzyme":[122],"shows":[123],"similar":[125],"profile":[127],"as":[128],"observed":[129],"sequence-based":[132],"studies.":[134],"However,":[135],"TyrRSs":[136],"Archaea/Eucarya":[138],"cluster":[139],"TrpRSs":[141],"rather":[142],"than":[143],"their":[144],"bacterial":[145,177],"counterparts,":[146],"root":[149],"locates":[152],"branch":[156],"indicating":[159],"origin":[162],"TrpRS.":[164],"Moreover,":[165],"short":[167],"distance":[168],"between":[169,176],"that":[175,189],"together":[181],"wide":[184],"distribution":[185],"suggest":[188],"emergence":[191],"subsequent":[195],"acquisition":[196],"by":[197],"Bacteria":[198],"occurred":[199],"stages":[202],"evolution.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
