{"id":"https://openalex.org/W2032740318","doi":"https://doi.org/10.1016/j.ymthe.2006.08.322","title":"268. CD19-Targeted Normal and CLL Patient T Cells Expanded with Beads Can Eradicate Systemic Tumors In Vivo","display_name":"268. CD19-Targeted Normal and CLL Patient T Cells Expanded with Beads Can Eradicate Systemic Tumors In Vivo","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2032740318","doi":"https://doi.org/10.1016/j.ymthe.2006.08.322","mag":"2032740318"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2006.08.322","doi":"https://doi.org/10.1016/j.ymthe.2006.08.322","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.322","pdf_url":"http://www.cell.com/article/S152500160600579X/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S152500160600579X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108208237","display_name":"J. Stefanski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Stefanski","raw_affiliation_strings":["Gene Transfer and Somatic Cell Engineering Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Transfer and Somatic Cell Engineering Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065556543","display_name":"Renier J. Brentjens","orcid":"https://orcid.org/0000-0002-3364-5388","observed_orcids":["https://orcid.org/0000-0002-3364-5388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Brentjens","raw_affiliation_strings":["Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085479412","display_name":"Daniel Hollyman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Hollyman","raw_affiliation_strings":["Gene Transfer and Somatic Cell Engineering Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Transfer and Somatic Cell Engineering Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109936370","display_name":"Mark L. Bonyhadi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Bonyhadi","raw_affiliation_strings":["Gene Transfer and Somatic Cell Engineering Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Transfer and Somatic Cell Engineering Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059625599","display_name":"Michel Sadelain","orcid":"https://orcid.org/0000-0002-9031-8025","observed_orcids":["https://orcid.org/0000-0002-9031-8025"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sadelain","raw_affiliation_strings":["Gene Transfer and Somatic Cell Engineering Laboratory","Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Transfer and Somatic Cell Engineering Laboratory","institution_ids":[]},{"raw_affiliation_string":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036831073","display_name":"Isabelle Rivi\u00e8re","orcid":"https://orcid.org/0000-0002-7363-3963","observed_orcids":["https://orcid.org/0000-0002-7363-3963"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Rivi\u00e8re","raw_affiliation_strings":["Gene Transfer and Somatic Cell Engineering Laboratory","Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Transfer and Somatic Cell Engineering Laboratory","institution_ids":[]},{"raw_affiliation_string":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.1631,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5658575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":null,"first_page":"S102","last_page":"S102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.8379999995231628},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.6959999799728394},{"id":"https://openalex.org/keywords/dynabeads","display_name":"Dynabeads","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cd3zeta","display_name":"CD3zeta","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-eradication","display_name":"tumor eradication","score":0.6150000095367432},{"id":"https://openalex.org/keywords/genetically-modified-t-cells","display_name":"genetically modified T cells","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6110016703605652},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49483269453048706},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.4822703003883362},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4623507261276245},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.458662211894989},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4528045952320099},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.44633564352989197},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4454256594181061},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4418715238571167},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4207629859447479},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.41688475012779236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4133087992668152},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3706390857696533},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3386189937591553},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23602578043937683},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15193438529968262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14512893557548523}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ymthe.2006.08.322","doi":"https://doi.org/10.1016/j.ymthe.2006.08.322","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.322","pdf_url":"http://www.cell.com/article/S152500160600579X/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2006.08.322","doi":"https://doi.org/10.1016/j.ymthe.2006.08.322","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.322","pdf_url":"http://www.cell.com/article/S152500160600579X/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032740318.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007802550","https://openalex.org/W2047192675","https://openalex.org/W2578290544","https://openalex.org/W2595299561","https://openalex.org/W2287640193","https://openalex.org/W2575016736","https://openalex.org/W2979691690","https://openalex.org/W2329728254","https://openalex.org/W2588961295","https://openalex.org/W1971746066"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,35,50,71,82],"conduct":[3],"a":[4,63],"clinical":[5],"trial":[6],"of":[7,24,39,88,98,102],"adoptive":[8],"therapy":[9],"with":[10,17],"genetically":[11,48],"modified":[12,49],"T":[13,27,43,45,105],"cells":[14,46],"in":[15],"patients":[16],"CLL,":[18],"we":[19],"are":[20,47],"investigating":[21],"the":[22,72,83,89,95,99,103],"feasibility":[23],"ex":[25],"vivo":[26],"cell":[28,106],"transduction":[29],"and":[30,85,94],"expansion":[31],"using":[32],"Xcyte\u2122":[33],"Dynabeads\u00ae":[34],"generate":[36],"sufficient":[37],"numbers":[38],"biologically":[40],"active":[41],"tumor-reactive":[42],"cells.":[44],"express":[51],"19-28z":[52,58],"chimeric":[53],"antigen":[54,75],"receptor":[55,93],"(CAR).":[56],"The":[57],"CAR":[59],"is":[60],"derived":[61],"from":[62],"single":[64],"chain":[65,101],"fragment":[66],"length":[67],"murine":[68],"antibody":[69],"specific":[70],"human":[73,90,104],"CD19":[74],"expressed":[76],"on":[77],"CLL":[78],"tumor":[79],"cells,":[80],"fused":[81],"transmembrane":[84],"cytoplasmic":[86,96],"domains":[87],"CD28":[91],"co-stimulatory":[92],"domain":[97],"CD3\u03b6":[100],"receptor.":[107]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}