{"id":"https://openalex.org/W2032669737","doi":"https://doi.org/10.1016/j.jalz.2013.05.428","title":"P1\u2013204: Identifying novel CSF markers of brain atrophy in Alzheimer's disease and mild cognitive impairment using a multiplex panel of analytes","display_name":"P1\u2013204: Identifying novel CSF markers of brain atrophy in Alzheimer's disease and mild cognitive impairment using a multiplex panel of analytes","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2032669737","doi":"https://doi.org/10.1016/j.jalz.2013.05.428","mag":"2032669737"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2013.05.428","doi":"https://doi.org/10.1016/j.jalz.2013.05.428","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2013.05.428","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107385959","display_name":"Steven John Kiddle","orcid":"https://orcid.org/0000-0003-4350-7437","observed_orcids":["https://orcid.org/0000-0003-4350-7437"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Kiddle","raw_affiliation_strings":["King's College London  London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000289224","display_name":"Wasim Khan","orcid":"https://orcid.org/0000-0002-4489-4945","observed_orcids":["https://orcid.org/0000-0002-4489-4945"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Wasim Khan","raw_affiliation_strings":["King's College London  London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074406517","display_name":"Carlos Aguilar","orcid":"https://orcid.org/0000-0003-4321-2516","observed_orcids":["https://orcid.org/0000-0003-4321-2516"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carlos Aguilar","raw_affiliation_strings":["Karonlinska Institute  Stockholm Sweden","Karonlinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karonlinska Institute  Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Karonlinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069442898","display_name":"Madhav Thambisetty","orcid":"https://orcid.org/0000-0002-2200-2299","observed_orcids":["https://orcid.org/0000-0002-2200-2299"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Madhav Thambisetty","raw_affiliation_strings":["King's College London  London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068705596","display_name":"Martina Sattlecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martina Sattlecker","raw_affiliation_strings":["King's College, London  London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College, London  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004056310","display_name":"Stephen Newhouse","orcid":"https://orcid.org/0000-0002-1843-9842","observed_orcids":["https://orcid.org/0000-0002-1843-9842"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Newhouse","raw_affiliation_strings":["KCL  London United Kingdom","KCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KCL  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"KCL, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066918469","display_name":"Richard Dobson","orcid":"https://orcid.org/0000-0003-4224-9245","observed_orcids":["https://orcid.org/0000-0003-4224-9245"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Dobson","raw_affiliation_strings":["King's College London  London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109271739","display_name":"Andy Simmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andy Simmons","raw_affiliation_strings":["King's College London, Institute of Psychiatry  London United Kingdom","King's College, London, Institute of Psychiatry, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London, Institute of Psychiatry  London United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"King's College, London, Institute of Psychiatry, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000289224"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13125072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4S_Part_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9290000200271606},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C2779476363","wikidata":"https://www.wikidata.org/wiki/Q14864935","display_name":"Clusterin","level":3,"score":0.8244357109069824},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.6383631229400635},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5467603802680969},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.5362996459007263},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5243263840675354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.513745903968811},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5032321810722351},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.4792604446411133},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4239470362663269},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.42042461037635803},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.41503939032554626},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4075956642627716},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3514869213104248},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3484400808811188},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3128167390823364},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.273018479347229},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.24984368681907654},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18088296055793762},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16848862171173096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10692101716995239},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06472030282020569},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jalz.2013.05.428","doi":"https://doi.org/10.1016/j.jalz.2013.05.428","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2013.05.428","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1557870","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1557870/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer's & Dementia , 9 (4) P227-P227. (2013)","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/33d37a60-cc37-4105-8053-821f54bbc6a3","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/33d37a60-cc37-4105-8053-821f54bbc6a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kiddle, S, Khan, W, Aguilar, C, Thambisetty, M, Sattlecker, M, Newhouse, S, Dobson, R & Simmons, A 2013, 'Identifying novel CSF markers of brain atrophy in Alzheimer's disease and mild cognitive impairment using a multiplex panel of analytes', Alzheimer's Dementia: The Journal of the Alzheimer's Association, vol. 9, no. 4, Supplement, pp. P227-P227. https://doi.org/10.1016/j.jalz.2013.05.428","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6100000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001477615","https://openalex.org/W2167538572","https://openalex.org/W2399571624","https://openalex.org/W2902622269","https://openalex.org/W2170756672","https://openalex.org/W2803278045","https://openalex.org/W4321996625","https://openalex.org/W2892947965","https://openalex.org/W2121201648","https://openalex.org/W2088129757"],"abstract_inverted_index":{"Background:":[0],"Cerebrospinal":[1],"fluid":[2],"(CSF)":[3],"has":[4],"provided":[5],"some":[6],"of":[7,12,26,52,60,83,135,138,147,153,202,219,231,244,338],"the":[8,24,49,57,71,90,151,154,265,281],"most":[9],"promising":[10],"source":[11],"validated":[13],"biomarkers":[14,20,63,160,273,324],"in":[15,33,42,79,112,262,311,315,341,351],"Alzheimer's":[16,72],"disease":[17,28,53,345],"(AD).":[18],"Such":[19],"are":[21],"critical":[22],"to":[23,131,168,182,258,298,317,354],"development":[25],"novel":[27],"modifying":[29],"treatments":[30],"for":[31,47,64,284,325],"use":[32],"research":[34],"and":[35,55,105,140,164,173,177,256,270,278,288,294,320,328,344],"clinical":[36,58,260],"practice.":[37],"There":[38],"is":[39,349],"great":[40],"interest":[41],"specific":[43],"CSF":[44,85,159,272,312],"protein":[45],"candidates":[46,310],"measuring":[48],"earliest":[50],"stages":[51],"progression":[54,261],"improving":[56],"utility":[59],"traditional":[61,158,271],"AD":[62,172,183,287,299,323,326,342],"accurate":[65],"diagnosis.":[66],"Methods:":[67],"Data":[68],"acquired":[69,119],"from":[70],"Disease":[73],"Neuroimaging":[74],"(ADNI)":[75],"study":[76,148],"was":[77,129],"used":[78,130],"this":[80],"study.":[81],"Levels":[82],"159":[84],"analytes":[86,203,233],"were":[87,110,241,313],"measured":[88],"using":[89,122],"Rules":[91],"Based":[92],"Medicine":[93],"(RBM,":[94],"Austin,":[95],"TX)":[96],"Human":[97],"Discovery":[98],"Multi-Analyte":[99],"Profile":[100],"1.0":[101],"panel.":[102],"Global":[103],"volumetric":[104],"regional":[106],"thickness":[107,246],"MRI":[108,166,269],"measurements":[109],"determined":[111],"295":[113],"ADNI":[114],"subjects":[115,176,290],"(AD=65,":[116],"MCI=142,":[117],"HC=88)":[118],"at":[120,185,291,300],"baseline":[121,292],"Freesurfer":[123],"5.1.0.":[124],"The":[125],"multiplex":[126],"analyte":[127,155,266,309],"panel":[128,156,267],"identify":[132],"a":[133,186,200,301,336],"subset":[134,201],"proteins":[136,340],"predictive":[137,218,243],"hippocampal":[139,220],"entorhinal":[141],"cortex":[142],"(ERC)":[143],"atrophy.":[144],"Another":[145],"avenue":[146],"also":[149,242],"examined":[150],"combination":[152],"with":[157,268],"(A\u03b2142,":[161],"p-tau,":[162],"t-tau)":[163,279],"structural":[165],"measures":[167],"1)":[169],"distinguish":[170],"between":[171,286],"healthy":[174],"controls":[175],"2)":[178],"predict":[179],"future":[180,329],"MCI":[181,296,330],"conversion":[184,297,331],"one":[187,302],"year":[188,303],"follow":[189,304],"up.":[190],"Results:":[191],"Multiple":[192],"linear":[193],"regression":[194],"analysis":[195],"by":[196],"cross":[197,224,250],"validation":[198,225,251],"identified":[199,314],"(FABP,":[204,234],"CgA,":[205,235],"ApoE,":[206],"NGAL,":[207,239],"PLGF,":[208],"TNFR2,":[209],"leptin,":[210],"VEGF,":[211],"ApoD,":[212],"ApoA-1,":[213],"prolactin,":[214,236],"clusterin,":[215],"TM,":[216,238],"SCF)":[217],"atrophy":[221,247,319],"(5":[222,248],"fold":[223,249],"R":[226,252],"2":[227,253],"=":[228,254],"35.6%).":[229],"Several":[230],"these":[232,339,356],"apoD,":[237],"clusterin)":[240],"ERC":[245],"30.2%)":[255],"related":[257],"rapid":[259],"AD.":[263],"Combining":[264],"(A\u03b2":[274],"1-42,":[275],"p-tau":[276],"181,":[277],"produced":[280],"best":[282],"model":[283],"distinguishing":[285],"HC":[289],"(92.7%)":[293],"predicting":[295],"up":[305],"(82.4%).":[306],"Conclusions:":[307],"Novel":[308],"relation":[316],"brain":[318],"complement":[321],"existing":[322],"classification":[327],"prediction.":[332],"This":[333],"may":[334],"suggest":[335],"role":[337],"pathogenesis":[343],"progression.":[346],"Further":[347],"work":[348],"required":[350],"independent":[352],"samples":[353],"replicate":[355],"findings.":[357]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2025-10-10T00:00:00"}