{"id":"https://openalex.org/W2032665239","doi":"https://doi.org/10.1016/0022-2836(91)90881-6","title":"Aggregation and secondary structure of synthetic amyloid \u03b2A4 peptides of Alzheimer's disease","display_name":"Aggregation and secondary structure of synthetic amyloid \u03b2A4 peptides of Alzheimer's disease","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2032665239","doi":"https://doi.org/10.1016/0022-2836(91)90881-6","mag":"2032665239","pmid":"https://pubmed.ncbi.nlm.nih.gov/2002499"},"language":"en","primary_location":{"id":"doi:10.1016/0022-2836(91)90881-6","doi":"https://doi.org/10.1016/0022-2836(91)90881-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(91)90881-6","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2032665239"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007423209","display_name":"C. Hilbich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caroline Hilbich","raw_affiliation_strings":["Center for Molecular Biology, University of Heidelberg, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology, University of Heidelberg, F.R.G","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066270769","display_name":"Brigitte Kisters\u2013Woike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brigitte Kisters-Woike","raw_affiliation_strings":["Center for Molecular Biology University of Heidelberg, Im Neuenheimer Feld 282, 6900 Heidelberg, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology University of Heidelberg, Im Neuenheimer Feld 282, 6900 Heidelberg, F.R.G","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111920087","display_name":"Jennifer Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jennifer Reed","raw_affiliation_strings":["Institute for Experimental Pathology German Cancer Research Center, Im Neuenheimer Feld 280, 6900 Heidelberg, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Pathology German Cancer Research Center, Im Neuenheimer Feld 280, 6900 Heidelberg, F.R.G","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047385288","display_name":"Colin Louis Masters","orcid":"https://orcid.org/0000-0003-3072-7940","observed_orcids":["https://orcid.org/0000-0003-3072-7940"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Colin L. Masters","raw_affiliation_strings":["Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112198503","display_name":"Konrad T. Beyreuther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Konrad Beyreuther","raw_affiliation_strings":["Center for Molecular Biology University of Heidelberg, Im Neuenheimer Feld 282, 6900 Heidelberg, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology University of Heidelberg, Im Neuenheimer Feld 282, 6900 Heidelberg, F.R.G","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":11.839,"has_fulltext":false,"cited_by_count":585,"citation_normalized_percentile":{"value":0.99335175,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"218","issue":"1","first_page":"149","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peptide-aggregation","display_name":"peptide aggregation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.746999979019165},{"id":"https://openalex.org/keywords/secondary-structure","display_name":"secondary structure","score":0.734000027179718},{"id":"https://openalex.org/keywords/beta-turn","display_name":"beta-turn","score":0.9039999842643738},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hydrophobic-effect","display_name":"hydrophobic effect","score":0.9010000228881836},{"id":"https://openalex.org/keywords/peptide-analogs","display_name":"peptide analogues","score":0.6499999761581421},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.9049999713897705},{"id":"https://openalex.org/keywords/peptide-dimers","display_name":"peptide dimers","score":0.5879999995231628},{"id":"https://openalex.org/keywords/hydrophobic-residues","display_name":"hydrophobic residues","score":0.6759999990463257},{"id":"https://openalex.org/keywords/peptide-solubility","display_name":"peptide solubility","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.8145368099212646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7386939525604248},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7231813669204712},{"id":"https://openalex.org/C159547669","wikidata":"https://www.wikidata.org/wiki/Q283449","display_name":"Beta sheet","level":3,"score":0.71873939037323},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.7095610499382019},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.6968307495117188},{"id":"https://openalex.org/C34349673","wikidata":"https://www.wikidata.org/wiki/Q899124","display_name":"Random coil","level":3,"score":0.6081830263137817},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.6047409176826477},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5333144068717957},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.45304229855537415},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4387558400630951},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.4236748218536377},{"id":"https://openalex.org/C2778896982","wikidata":"https://www.wikidata.org/wiki/Q2033625","display_name":"Thioflavin","level":4,"score":0.4160594344139099},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.41300010681152344},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3728777766227722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36373671889305115},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.14857783913612366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10286355018615723},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007382","descriptor_name":"Intermediate Filaments","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-2836(91)90881-6","doi":"https://doi.org/10.1016/0022-2836(91)90881-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(91)90881-6","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:2002499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2002499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W47014566","https://openalex.org/W157808733","https://openalex.org/W1480950303","https://openalex.org/W1758831574","https://openalex.org/W1885793991","https://openalex.org/W1934853983","https://openalex.org/W1967339275","https://openalex.org/W1990332976","https://openalex.org/W1999437155","https://openalex.org/W2006116784","https://openalex.org/W2013833879","https://openalex.org/W2014550271","https://openalex.org/W2015675204","https://openalex.org/W2017643275","https://openalex.org/W2018908557","https://openalex.org/W2019369720","https://openalex.org/W2020745281","https://openalex.org/W2021417643","https://openalex.org/W2024249016","https://openalex.org/W2027502723","https://openalex.org/W2036102892","https://openalex.org/W2038086035","https://openalex.org/W2046847750","https://openalex.org/W2060633236","https://openalex.org/W2061111679","https://openalex.org/W2067873532","https://openalex.org/W2076352068","https://openalex.org/W2079384663","https://openalex.org/W2081881251","https://openalex.org/W2086207996","https://openalex.org/W2100837269","https://openalex.org/W2113403117","https://openalex.org/W2128963115","https://openalex.org/W2161399088","https://openalex.org/W2333470577","https://openalex.org/W2341945205","https://openalex.org/W4323284750"],"related_works":["https://openalex.org/W31577248","https://openalex.org/W1516306407","https://openalex.org/W2130144581","https://openalex.org/W2012895864","https://openalex.org/W1994232621","https://openalex.org/W2092887599","https://openalex.org/W2017643275","https://openalex.org/W1982635793","https://openalex.org/W2074666645","https://openalex.org/W2008524154"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
