{"id":"https://openalex.org/W2032652519","doi":"https://doi.org/10.1021/pr070138h","title":"Post-Translational Modifications in the Nuclear Region of Young, Aged, and Cataract Human Lenses","display_name":"Post-Translational Modifications in the Nuclear Region of Young, Aged, and Cataract Human Lenses","publication_year":2007,"publication_date":"2007-09-07","ids":{"openalex":"https://openalex.org/W2032652519","doi":"https://doi.org/10.1021/pr070138h","mag":"2032652519","pmid":"https://pubmed.ncbi.nlm.nih.gov/17824632"},"language":"en","primary_location":{"id":"doi:10.1021/pr070138h","doi":"https://doi.org/10.1021/pr070138h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr070138h","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003750584","display_name":"Peter G. Hains","orcid":"https://orcid.org/0000-0002-7276-1760","observed_orcids":["https://orcid.org/0000-0002-7276-1760"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter G. Hains","raw_affiliation_strings":["Save Sight Institute, University of Sydney, Sydney, NSW, 2001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Save Sight Institute, University of Sydney, Sydney, NSW, 2001, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110058663","display_name":"Roger J.W. Truscott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roger J. W. Truscott","raw_affiliation_strings":["Save Sight Institute, University of Sydney, Sydney, NSW, 2001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Save Sight Institute, University of Sydney, Sydney, NSW, 2001, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.4404,"has_fulltext":false,"cited_by_count":167,"citation_normalized_percentile":{"value":0.96017155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"6","issue":"10","first_page":"3935","last_page":"3943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.15379999577999115,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.066600002348423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-cataract","display_name":"nuclear cataract","score":0.9319999814033508},{"id":"https://openalex.org/keywords/human-lens","display_name":"human lens","score":0.6399999856948853},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8479999899864197},{"id":"https://openalex.org/keywords/deamidation","display_name":"deamidation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tryptophan-oxidation","display_name":"tryptophan oxidation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lens-aging","display_name":"lens aging","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nuclear-proteins","display_name":"nuclear proteins","score":0.5600000023841858},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.5320000052452087},{"id":"https://openalex.org/keywords/age-related-lens-changes","display_name":"age-related lens changes","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2780784506","wikidata":"https://www.wikidata.org/wiki/Q4859711","display_name":"Deamidation","level":3,"score":0.9788590669631958},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.6149961948394775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5473268032073975},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.4978513717651367},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.4535083770751953},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.33171314001083374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2815386950969696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2685105800628662},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1199430525302887},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10803309082984924}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007907","descriptor_name":"Lens Nucleus, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/pr070138h","doi":"https://doi.org/10.1021/pr070138h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr070138h","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:17824632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17824632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8681353950","display_name":"NUCLEAR CATARACT: ROLE OF UV FILTERS AND THE LENS BARRIER","funder_award_id":"R01EY013570","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1182847794","https://openalex.org/W1264194531","https://openalex.org/W1539653122","https://openalex.org/W1603656371","https://openalex.org/W1900477555","https://openalex.org/W1973051173","https://openalex.org/W1975980571","https://openalex.org/W1976138256","https://openalex.org/W1990105567","https://openalex.org/W1992194517","https://openalex.org/W1992341964","https://openalex.org/W1992608741","https://openalex.org/W1993718695","https://openalex.org/W1998540975","https://openalex.org/W2000005896","https://openalex.org/W2004015458","https://openalex.org/W2005668371","https://openalex.org/W2010981463","https://openalex.org/W2018124999","https://openalex.org/W2024120301","https://openalex.org/W2029667189","https://openalex.org/W2030441812","https://openalex.org/W2030511242","https://openalex.org/W2056300299","https://openalex.org/W2066303560","https://openalex.org/W2068792255","https://openalex.org/W2072466025","https://openalex.org/W2076805523","https://openalex.org/W2082125965","https://openalex.org/W2086929292","https://openalex.org/W2086963517","https://openalex.org/W2089130407","https://openalex.org/W2098748373","https://openalex.org/W2099542937","https://openalex.org/W2130920644","https://openalex.org/W2132561264","https://openalex.org/W2144544590","https://openalex.org/W2158811619","https://openalex.org/W2163501992","https://openalex.org/W2165241568","https://openalex.org/W2171938017","https://openalex.org/W2465587552","https://openalex.org/W4251647708"],"related_works":["https://openalex.org/W3094018919","https://openalex.org/W2112324286","https://openalex.org/W2083030188","https://openalex.org/W2567818760","https://openalex.org/W84546861","https://openalex.org/W1992341964","https://openalex.org/W2883597085","https://openalex.org/W6939780140","https://openalex.org/W154019045","https://openalex.org/W1229018818"],"abstract_inverted_index":{"The":[0],"urea-soluble":[1],"proteins":[2],"from":[3],"the":[4,37,58,88,104],"nucleus":[5],"of":[6,43,60,77,90,106],"two":[7,9,12],"young,":[8],"aged,":[10],"and":[11,22],"early-stage":[13],"nuclear":[14,91,128],"cataract":[15,48,111,129],"lenses":[16,112],"were":[17,31,45],"subjected":[18],"to":[19,50,70,97,115],"tryptic":[20],"digestion":[21],"analysis":[23,65],"by":[24,35],"2D":[25],"LC-MS/MS.":[26],"Several":[27],"novel":[28],"post-translational":[29],"modifications":[30],"identified.":[32],"Deamidation":[33],"was,":[34],"far,":[36],"most":[38,53],"common":[39],"modification.":[40],"A":[41],"number":[42,59],"differences":[44],"found":[46],"in":[47,57,95,103,110,127],"compared":[49,114],"normal":[51,117],"lenses,":[52],"notably":[54],"an":[55,101],"increase":[56,86,102],"oxidized":[61],"tryptophan":[62],"residues.":[63],"Semiquantitative":[64],"revealed":[66],"that":[67],"there":[68,82],"appeared":[69],"be":[71,125],"a":[72],"trend":[73],"toward":[74],"increased":[75],"levels":[76],"deamidation":[78],"with":[79],"age;":[80],"however,":[81],"was":[83,108],"no":[84],"apparent":[85,109],"upon":[87],"onset":[89],"cataract.":[92],"This":[93],"is":[94],"contrast":[96],"Trp":[98,122],"oxidation,":[99],"where":[100],"extent":[105],"modification":[107],"when":[113],"aged":[116],"lenses.":[118],"These":[119],"findings":[120],"suggest":[121],"oxidation":[123],"may":[124],"involved":[126],"development.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}