{"id":"https://openalex.org/W2032587350","doi":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","title":"Antisense inhibition of protein phosphatase 2C accelerates cold acclimation in Arabidopsis thaliana","display_name":"Antisense inhibition of protein phosphatase 2C accelerates cold acclimation in Arabidopsis thaliana","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2032587350","doi":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","mag":"2032587350","pmid":"https://pubmed.ncbi.nlm.nih.gov/11439132"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-313x.2001.2641048.x","doi":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2001.2641048.x","source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2001.2641048.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004232148","display_name":"Sari T\u00e4htiharju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sari T\u00e4htiharju","raw_affiliation_strings":["Department of Biosciences, Division of Genetics, PO Box 56, FIN-00014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, Division of Genetics, PO Box 56, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114008582","display_name":"Tapio E. Palva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tapio Palva","raw_affiliation_strings":["Department of Biosciences, Division of Genetics, Institute of Biotechnology, PO Box 56, FIN\u201000014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, Division of Genetics, Institute of Biotechnology, PO Box 56, FIN\u201000014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":19.9619,"has_fulltext":true,"cited_by_count":220,"citation_normalized_percentile":{"value":0.9940538,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"26","issue":"4","first_page":"461","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11098","display_name":"Seed Germination and Physiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-2c","display_name":"protein phosphatase 2C","score":0.9909999966621399},{"id":"https://openalex.org/keywords/abi1","display_name":"ABI1","score":0.996999979019165},{"id":"https://openalex.org/keywords/cold-acclimation","display_name":"cold acclimation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/freeze-tolerance","display_name":"freezing tolerance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/abscisic-acid-signaling","display_name":"abscisic acid signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antisense-inhibition","display_name":"antisense inhibition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8650000095367432},{"id":"https://openalex.org/keywords/abiotic-stress-response","display_name":"abiotic stress response","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drought-stress","display_name":"drought stress","score":0.6959999799728394},{"id":"https://openalex.org/keywords/salt-stress","display_name":"salt stress","score":0.8640000224113464},{"id":"https://openalex.org/keywords/seed-germination","display_name":"seed germination","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2779591172","wikidata":"https://www.wikidata.org/wiki/Q332211","display_name":"Abscisic acid","level":3,"score":0.6846120953559875},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.6642734408378601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.584356427192688},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.56843101978302},{"id":"https://openalex.org/C119406331","wikidata":"https://www.wikidata.org/wiki/Q419763","display_name":"Acclimatization","level":2,"score":0.5543851852416992},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5526226758956909},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5247198343276978},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.505359947681427},{"id":"https://openalex.org/C89519541","wikidata":"https://www.wikidata.org/wiki/Q4667893","display_name":"Abiotic stress","level":3,"score":0.5041240453720093},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49324482679367065},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47375279664993286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3526305556297302},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3435365855693817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2170240879058838},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.09304109215736389}],"mesh":[{"descriptor_ui":"D000040","descriptor_name":"Abscisic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071636","descriptor_name":"Protein Phosphatase 2C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016373","descriptor_name":"DNA, Antisense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-313x.2001.2641048.x","doi":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2001.2641048.x","source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},{"id":"doi:10.1046/j.1365-313x.2001.01048.x","doi":"https://doi.org/10.1046/j.1365-313x.2001.01048.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2001.01048.x","pdf_url":null,"source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},{"id":"pmid:11439132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11439132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant journal : for cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-313x.2001.2641048.x","doi":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2001.2641048.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2001.2641048.x","source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032587350.pdf","grobid_xml":"https://content.openalex.org/works/W2032587350.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W200946802","https://openalex.org/W1543193423","https://openalex.org/W1864488908","https://openalex.org/W1964504843","https://openalex.org/W1974325028","https://openalex.org/W1977822694","https://openalex.org/W1981218861","https://openalex.org/W1984824352","https://openalex.org/W2002716098","https://openalex.org/W2003406255","https://openalex.org/W2006427593","https://openalex.org/W2012407846","https://openalex.org/W2012888959","https://openalex.org/W2021957032","https://openalex.org/W2025040786","https://openalex.org/W2029436676","https://openalex.org/W2030671473","https://openalex.org/W2049469558","https://openalex.org/W2052062475","https://openalex.org/W2056823766","https://openalex.org/W2057567296","https://openalex.org/W2059839942","https://openalex.org/W2060171209","https://openalex.org/W2064899851","https://openalex.org/W2065223043","https://openalex.org/W2067660931","https://openalex.org/W2075362706","https://openalex.org/W2083722533","https://openalex.org/W2084837508","https://openalex.org/W2090936658","https://openalex.org/W2095295932","https://openalex.org/W2106541825","https://openalex.org/W2107361633","https://openalex.org/W2131525307","https://openalex.org/W2141985540","https://openalex.org/W2142704168","https://openalex.org/W2171012097","https://openalex.org/W2267714437","https://openalex.org/W4249735284","https://openalex.org/W4250255422","https://openalex.org/W4251545677"],"related_works":["https://openalex.org/W975040337","https://openalex.org/W2056823766","https://openalex.org/W2794054290","https://openalex.org/W3192161893","https://openalex.org/W2097224448","https://openalex.org/W2145197821","https://openalex.org/W2160282405","https://openalex.org/W2885128510","https://openalex.org/W4233735474","https://openalex.org/W4385202024"],"abstract_inverted_index":{"Two":[0],"related":[1],"protein":[2],"phosphatases":[3],"2C,":[4],"ABI1":[5,36,54],"and":[6,35,42,53,63,67,138,163],"AtPP2CA":[7,25,34,52,110,190],"have":[8],"been":[9],"implicated":[10],"as":[11,94,96],"negative":[12,193],"regulators":[13],"of":[14,24,31,33,50,70,109,130,140,160,176,195],"ABA":[15,79,141,156,196],"signalling.":[16],"In":[17,82],"this":[18],"study":[19],"we":[20],"characterized":[21],"the":[22,84,107,115,174],"role":[23],"in":[26,39,43,77,90,97,100,111,143,147,169,182],"cold":[27,66,112,199],"acclimation.":[28,200],"The":[29,48,65],"pattern":[30],"expression":[32,49,69,93,175],"was":[37,55,73,118,180],"studied":[38],"different":[40],"tissues":[41],"response":[44,101],"to":[45,102,135,155],"abiotic":[46],"stresses.":[47],"both":[51,157],"induced":[56],"by":[57,120],"low":[58,103,136],"temperature,":[59],"drought,":[60],"high":[61],"salt":[62],"ABA.":[64],"drought-induced":[68],"these":[71],"genes":[72,87,179],"ABA-dependent,":[74],"but":[75,167],"divergent":[76],"various":[78],"signalling":[80],"mutants.":[81],"addition,":[83],"two":[85],"PP2C":[86],"exhibited":[88,126],"differences":[89],"their":[91,170],"tissue-specific":[92],"well":[95],"temporal":[98],"induction":[99],"temperature.":[104],"To":[105],"elucidate":[106],"function":[108],"acclimation":[113],"further,":[114],"corresponding":[116],"gene":[117],"silenced":[119],"antisense":[121,124,148,184],"inhibition.":[122],"Transgenic":[123],"plants":[125,151],"clearly":[127],"accelerated":[128],"development":[129,159],"freezing":[131,145],"tolerance.":[132],"Both":[133],"exposure":[134],"temperature":[137],"application":[139],"resulted":[142],"enhanced":[144,181],"tolerance":[146,162],"plants.":[149,185],"These":[150],"displayed":[152],"increased":[153],"sensitivity":[154],"during":[158,164,198],"frost":[161],"seed":[165],"germination,":[166],"not":[168],"drought":[171],"responses.":[172],"Furthermore,":[173],"cold-and":[177],"ABA-induced":[178],"transgenic":[183],"Our":[186],"results":[187],"suggest":[188],"that":[189],"is":[191],"a":[192],"regulator":[194],"responses":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}