{"id":"https://openalex.org/W2032467461","doi":"https://doi.org/10.1016/j.ejcb.2006.06.001","title":"Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells","display_name":"Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells","publication_year":2006,"publication_date":"2006-07-25","ids":{"openalex":"https://openalex.org/W2032467461","doi":"https://doi.org/10.1016/j.ejcb.2006.06.001","mag":"2032467461","pmid":"https://pubmed.ncbi.nlm.nih.gov/16860436"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejcb.2006.06.001","doi":"https://doi.org/10.1016/j.ejcb.2006.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejcb.2006.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S170067410","display_name":"European Journal of Cell Biology","issn_l":"0171-9335","issn":["0171-9335","1618-1298"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dae Sik Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae Sik Kwon","raw_affiliation_strings":["Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041150612","display_name":"Chae Hwa Kwon","orcid":"https://orcid.org/0000-0003-2277-1570","observed_orcids":["https://orcid.org/0000-0003-2277-1570"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chae Hwa Kwon","raw_affiliation_strings":["Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649967","display_name":"Jae Ho Kim","orcid":"https://orcid.org/0000-0003-4323-4790","observed_orcids":["https://orcid.org/0000-0003-4323-4790"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Ho Kim","raw_affiliation_strings":["Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011313346","display_name":"Jae Suk Woo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Suk Woo","raw_affiliation_strings":["Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101986530","display_name":"Jin Sup Jung","orcid":"https://orcid.org/0000-0002-7643-0918","observed_orcids":["https://orcid.org/0000-0002-7643-0918"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Sup Jung","raw_affiliation_strings":["Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083485699","display_name":"Yong Keun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Keun Kim","raw_affiliation_strings":["Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602-739, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083485699"],"corresponding_institution_ids":["https://openalex.org/I4921948"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":4.6567,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.94506213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"85","issue":"11","first_page":"1189","last_page":"1199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-reoxygenation","display_name":"hypoxia/reoxygenation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ischemia-reperfusion","display_name":"ischemia-reperfusion","score":0.7620000243186951},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/renal-epithelial-cells","display_name":"renal epithelial cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/opossum-kidney-cells","display_name":"opossum kidney cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.7900000214576721},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.984000027179718},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8154177069664001},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7888067960739136},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6394911408424377},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.589388906955719},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5614407062530518},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5381518006324768},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.5347555875778198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4920365512371063},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4825546145439148},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.47532063722610474},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4220023453235626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3627516031265259},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20645451545715332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16538146138191223},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.14496999979019165},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.10472971200942993}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002070","descriptor_name":"Butadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009893","descriptor_name":"Opossums","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejcb.2006.06.001","doi":"https://doi.org/10.1016/j.ejcb.2006.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejcb.2006.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S170067410","display_name":"European Journal of Cell Biology","issn_l":"0171-9335","issn":["0171-9335","1618-1298"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmid:16860436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16860436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W188486901","https://openalex.org/W228748825","https://openalex.org/W1510592624","https://openalex.org/W1557686543","https://openalex.org/W1586163533","https://openalex.org/W1791888878","https://openalex.org/W1841977166","https://openalex.org/W1919174089","https://openalex.org/W1949907309","https://openalex.org/W1963965447","https://openalex.org/W1964231591","https://openalex.org/W1965339862","https://openalex.org/W1968259548","https://openalex.org/W1975212546","https://openalex.org/W1976214230","https://openalex.org/W1976385326","https://openalex.org/W1979012323","https://openalex.org/W1985341418","https://openalex.org/W1985657656","https://openalex.org/W1990065094","https://openalex.org/W1991782173","https://openalex.org/W1993216157","https://openalex.org/W1999027333","https://openalex.org/W2009617568","https://openalex.org/W2010489503","https://openalex.org/W2017292900","https://openalex.org/W2027872174","https://openalex.org/W2029524083","https://openalex.org/W2032350328","https://openalex.org/W2033801757","https://openalex.org/W2038000923","https://openalex.org/W2039854908","https://openalex.org/W2040617188","https://openalex.org/W2042306398","https://openalex.org/W2044078154","https://openalex.org/W2045010231","https://openalex.org/W2052674054","https://openalex.org/W2053174155","https://openalex.org/W2057888676","https://openalex.org/W2063072318","https://openalex.org/W2064253775","https://openalex.org/W2070169837","https://openalex.org/W2070985748","https://openalex.org/W2086450927","https://openalex.org/W2087846936","https://openalex.org/W2088472722","https://openalex.org/W2098449806","https://openalex.org/W2102500299","https://openalex.org/W2118193468","https://openalex.org/W2121529957","https://openalex.org/W2121976123","https://openalex.org/W2130594577","https://openalex.org/W2131484844","https://openalex.org/W2134850272","https://openalex.org/W2147993424","https://openalex.org/W2150863197","https://openalex.org/W2153687750","https://openalex.org/W2159453240","https://openalex.org/W2160713807","https://openalex.org/W2165830726","https://openalex.org/W2232375595","https://openalex.org/W2313503300","https://openalex.org/W2330694540","https://openalex.org/W2332519193","https://openalex.org/W2334270469","https://openalex.org/W2408913569","https://openalex.org/W2411266928","https://openalex.org/W6638920074","https://openalex.org/W6640597815","https://openalex.org/W6713605717"],"related_works":["https://openalex.org/W2066789184","https://openalex.org/W2040617188","https://openalex.org/W2020776894","https://openalex.org/W2087452111","https://openalex.org/W2153263227","https://openalex.org/W7099369235","https://openalex.org/W2174059881","https://openalex.org/W2059315370","https://openalex.org/W2024495413","https://openalex.org/W2118193468"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
