{"id":"https://openalex.org/W2032406332","doi":"https://doi.org/10.1074/jbc.m409786200","title":"Bacteriophage T4Dam DNA-(Adenine-N6)-methyltransferase","display_name":"Bacteriophage T4Dam DNA-(Adenine-N6)-methyltransferase","publication_year":2004,"publication_date":"2004-09-17","ids":{"openalex":"https://openalex.org/W2032406332","doi":"https://doi.org/10.1074/jbc.m409786200","mag":"2032406332","pmid":"https://pubmed.ncbi.nlm.nih.gov/15375160"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m409786200","doi":"https://doi.org/10.1074/jbc.m409786200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m409786200","pdf_url":"http://www.jbc.org/article/S0021925820677912/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820677912/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109831272","display_name":"Ernst G. Malygin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802000777","display_name":"State Research Center of Virology and Biotechnology VECTOR","ror":"https://ror.org/00z7n1h55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1318325419","https://openalex.org/I2802000777"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ernst G. Malygin","raw_affiliation_strings":["Institute of Molecular Biology, State Research Center of Virology and Biotechnology \"Vector,\" Novosibirsk 630559, Russia","Institute of Molecular Biology, State Research Center of Virology and Biotechnology \u201cVector,\u201d Novosibirsk 630559, Russia, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, State Research Center of Virology and Biotechnology \"Vector,\" Novosibirsk 630559, Russia","institution_ids":["https://openalex.org/I2802000777"]},{"raw_affiliation_string":"Institute of Molecular Biology, State Research Center of Virology and Biotechnology \u201cVector,\u201d Novosibirsk 630559, Russia, the","institution_ids":["https://openalex.org/I2802000777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019466584","display_name":"Bianca Sclavi","orcid":"https://orcid.org/0000-0002-3883-8592","observed_orcids":["https://orcid.org/0000-0002-3883-8592"]},"institutions":[{"id":"https://openalex.org/I11559806","display_name":"\u00c9cole Normale Sup\u00e9rieure Paris-Saclay","ror":"https://ror.org/00hx6zz33","country_code":"FR","type":"education","lineage":["https://openalex.org/I11559806","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210150317","display_name":"Laboratoire de Biologie et Pharmacologie Appliqu\u00e9e","ror":"https://ror.org/03njrcx45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I11559806","https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210150317"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bianca Sclavi","raw_affiliation_strings":["Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie Ge\u0301ne\u0301tique Applique\u0301es (UMR 8113 du CNRS) Ecole Normale Superieur de Cachan, 94235 CACHAN, France","Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie G\u00e9n\u00e9tique Appliqu\u00e9es (UMR 8113 du CNRS), Ecole Normale Superieur de Cachan, 94235 Cachan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie Ge\u0301ne\u0301tique Applique\u0301es (UMR 8113 du CNRS) Ecole Normale Superieur de Cachan, 94235 CACHAN, France","institution_ids":["https://openalex.org/I11559806","https://openalex.org/I1294671590","https://openalex.org/I4210150317"]},{"raw_affiliation_string":"Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie G\u00e9n\u00e9tique Appliqu\u00e9es (UMR 8113 du CNRS), Ecole Normale Superieur de Cachan, 94235 Cachan, France","institution_ids":["https://openalex.org/I11559806","https://openalex.org/I1294671590","https://openalex.org/I4210150317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113529510","display_name":"Victor V. Zinoviev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802000777","display_name":"State Research Center of Virology and Biotechnology VECTOR","ror":"https://ror.org/00z7n1h55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1318325419","https://openalex.org/I2802000777"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Victor V. Zinoviev","raw_affiliation_strings":["Institute of Molecular Biology, State Research Center of Virology and Biotechnology \u201cVector,\u201d Novosibirsk 630559, Russia, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, State Research Center of Virology and Biotechnology \u201cVector,\u201d Novosibirsk 630559, Russia, the","institution_ids":["https://openalex.org/I2802000777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110876933","display_name":"Alexey A. Evdokimov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802000777","display_name":"State Research Center of Virology and Biotechnology VECTOR","ror":"https://ror.org/00z7n1h55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1318325419","https://openalex.org/I2802000777"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey A. Evdokimov","raw_affiliation_strings":["Institute of Molecular Biology, State Research Center of Virology and Biotechnology \u201cVector,\u201d Novosibirsk 630559, Russia, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, State Research Center of Virology and Biotechnology \u201cVector,\u201d Novosibirsk 630559, Russia, the","institution_ids":["https://openalex.org/I2802000777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059725617","display_name":"Stanley Hattman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stanley Hattman","raw_affiliation_strings":["Department of Biology, University of Rochester, Rochester, New York 14627-0211, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester, Rochester, New York 14627-0211, and the","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058151358","display_name":"Malcolm Buckle","orcid":"https://orcid.org/0000-0001-7596-3467","observed_orcids":["https://orcid.org/0000-0001-7596-3467"]},"institutions":[{"id":"https://openalex.org/I11559806","display_name":"\u00c9cole Normale Sup\u00e9rieure Paris-Saclay","ror":"https://ror.org/00hx6zz33","country_code":"FR","type":"education","lineage":["https://openalex.org/I11559806","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210150317","display_name":"Laboratoire de Biologie et Pharmacologie Appliqu\u00e9e","ror":"https://ror.org/03njrcx45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I11559806","https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210150317"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Malcolm Buckle","raw_affiliation_strings":["Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie Ge\u0301ne\u0301tique Applique\u0301es (UMR 8113 du CNRS) Ecole Normale Superieur de Cachan, 94235 CACHAN, France","Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie G\u00e9n\u00e9tique Appliqu\u00e9es (UMR 8113 du CNRS), Ecole Normale Superieur de Cachan, 94235 Cachan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie Ge\u0301ne\u0301tique Applique\u0301es (UMR 8113 du CNRS) Ecole Normale Superieur de Cachan, 94235 CACHAN, France","institution_ids":["https://openalex.org/I11559806","https://openalex.org/I1294671590","https://openalex.org/I4210150317"]},{"raw_affiliation_string":"Enzymologie et Cinetique Structurale, Laboratoire de Biotechnologies et Pharmacologie G\u00e9n\u00e9tique Appliqu\u00e9es (UMR 8113 du CNRS), Ecole Normale Superieur de Cachan, 94235 Cachan, France","institution_ids":["https://openalex.org/I11559806","https://openalex.org/I1294671590","https://openalex.org/I4210150317"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059725617"],"corresponding_institution_ids":["https://openalex.org/I5388228"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.5918,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61953049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"279","issue":"48","first_page":"50012","last_page":"50018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.36570000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.36570000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.10909999907016754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/s-adenosylhomocysteine","display_name":"S-adenosylhomocysteine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pre-steady-state-kinetics","display_name":"pre-steady-state kinetics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/single-turnover-kinetics","display_name":"single-turnover kinetics","score":0.925000011920929},{"id":"https://openalex.org/keywords/enzyme-dimerization","display_name":"enzyme dimerization","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.685670793056488},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5294011831283569},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5260410308837891},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.42267918586730957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37881001830101013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34880977869033813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32698336243629456},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.13117364048957825},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.049732595682144165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.049723803997039795}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015265","descriptor_name":"Site-Specific DNA-Methyltransferase (Adenine-Specific)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m409786200","doi":"https://doi.org/10.1074/jbc.m409786200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m409786200","pdf_url":"http://www.jbc.org/article/S0021925820677912/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15375160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15375160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00277446v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00277446","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 2004, 279 (48), pp.50012-8. &#x27E8;10.1074/jbc.M409786200&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m409786200","doi":"https://doi.org/10.1074/jbc.m409786200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m409786200","pdf_url":"http://www.jbc.org/article/S0021925820677912/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.41999998688697815}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2990566259","display_name":"Effector roles of T4Dam DNA-methyltransferase subsrates","funder_award_id":"R03TW005755","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G6942631888","display_name":null,"funder_award_id":"GM29227","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7204913507","display_name":"DNA MODIFICATION/RESTRICTION IN PRO-AND EUKARYOTES","funder_award_id":"5r01gm029227-29","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032406332.pdf","grobid_xml":"https://content.openalex.org/works/W2032406332.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W2110276","https://openalex.org/W63401570","https://openalex.org/W88733460","https://openalex.org/W1481680796","https://openalex.org/W1966943689","https://openalex.org/W1969597965","https://openalex.org/W1973496342","https://openalex.org/W1980731929","https://openalex.org/W1986629210","https://openalex.org/W1986844235","https://openalex.org/W2005986251","https://openalex.org/W2008243144","https://openalex.org/W2008400365","https://openalex.org/W2024742337","https://openalex.org/W2034278917","https://openalex.org/W2039117092","https://openalex.org/W2048978731","https://openalex.org/W2051225798","https://openalex.org/W2059475921","https://openalex.org/W2059683924","https://openalex.org/W2062620144","https://openalex.org/W2065809202","https://openalex.org/W2086483206","https://openalex.org/W2091181823","https://openalex.org/W2094076196","https://openalex.org/W2097404504","https://openalex.org/W2106279890","https://openalex.org/W2108077666","https://openalex.org/W2119567071","https://openalex.org/W2128635872","https://openalex.org/W2152764495","https://openalex.org/W2163408209","https://openalex.org/W2168676571","https://openalex.org/W2169219018","https://openalex.org/W2276468011"],"related_works":["https://openalex.org/W2051225798","https://openalex.org/W2086483206","https://openalex.org/W1991776265","https://openalex.org/W2097404504","https://openalex.org/W2048978731","https://openalex.org/W2085777743","https://openalex.org/W2089400885","https://openalex.org/W2912302018","https://openalex.org/W1989187240","https://openalex.org/W2106359847"],"abstract_inverted_index":{"We":[0,167],"analyzed":[1],"pre-steady":[2,42,108],"state":[3,43,109,132],"and":[4,151,184],"single":[5,95,116,125,229],"turnover":[6,135,230],"kinetics":[7,120],"of":[8,51,54,66,78,93,137,158,161,180,236,243],"bacteriophage":[9],"T4Dam":[10,46,67,86],"DNA-(adenine-N(6))-methyltransferase-mediated":[11],"methyl":[12,171,186,200],"group":[13],"transfer":[14,172,187,201],"from":[15,35,88,223],"S-adenosyl-l-methionine":[16],"(AdoMet)":[17],"to":[18,68,173,188],"40-mer":[19,58,112,138,246],"duplexes":[20,59,113,139],"containing":[21,60,114],"native":[22],"recognition":[23],"sites":[24],"(5'-GATC/5'-GATC)":[25],"or":[26,220],"some":[27],"modified":[28],"variant(s).":[29],"The":[30],"results":[31],"extend":[32],"a":[33,94,115,124,129,154,163,204],"model":[34],"studies":[36],"with":[37,104,241],"single-site":[38],"20-mer":[39],"duplexes.":[40,247],"Under":[41,228],"conditions,":[44,231],"monomeric":[45],"methyltransferase-AdoMet":[47],"complexes":[48],"were":[49,102,121],"capable":[50,179],"rapid":[52],"methylation":[53,100,136,235],"adenine":[55,191,239],"residues":[56,240],"in":[57,142,210],"two":[61,107,143,146],"sites.":[62],"During":[63],"processive":[64,159],"movement":[65,160],"the":[69,72,76,79,89,119,189,193,211,224,244],"next":[70],"site,":[71,118],"rate-limiting":[73],"step":[74],"was":[75,178,215,233],"exchange":[77],"product":[80],"S-adenosyl-l-homocysteine":[81],"(AdoHcy)":[82],"for":[83],"AdoMet":[84],"without":[85],"dissociating":[87],"duplex.":[90],"Consequently,":[91],"instead":[92],"exponential":[96,126],"rate":[97,205],"dependence,":[98],"complex":[99],"curves":[101],"obtained":[103],"at":[105,203],"least":[106],"steps.":[110],"With":[111],"target":[117,190,238],"simpler,":[122],"fitting":[123],"followed":[127],"by":[128,217],"linear":[130],"steady":[131],"phase.":[133],"Single":[134],"also":[140],"proceeded":[141],"stages.":[144],"First,":[145],"dimeric":[147,176],"T4Dam-AdoMet":[148],"molecules":[149],"bound,":[150],"each":[152,242],"catalyzed":[153],"two-step":[155],"methylation.":[156],"Instead":[157],"T4Dam,":[162],"conformational":[164],"adaptation":[165],"occurred.":[166],"propose":[168],"that":[169],"following":[170],"one":[174],"strand,":[175],"(T4Dam-AdoMet)-(T4Dam-AdoHcy)":[177],"rapidly":[181],"reorienting":[182],"itself":[183],"catalyzing":[185],"on":[192],"complementary,":[194],"unmethylated":[195],"strand.":[196,227],"This":[197],"second":[198],"stage":[199],"occurred":[202],"about":[206],"25-fold":[207],"slower":[208],"than":[209],"first":[212],"step;":[213],"it":[214],"rate-limited":[216],"Dam-AdoHcy":[218],"dissociation":[219],"its":[221],"clearance":[222],"methylated":[225],"complementary":[226],"there":[232],"complete":[234],"all":[237],"two-site":[245]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
