{"id":"https://openalex.org/W2032397902","doi":"https://doi.org/10.1002/ijc.2910530523","title":"Insulin dependence of murine T\u2010cell lymphoma. II. Insulin\u2010deficient diabetic mice and mice fed low\u2010energy diet develop resistance to lymphoma growth","display_name":"Insulin dependence of murine T\u2010cell lymphoma. II. Insulin\u2010deficient diabetic mice and mice fed low\u2010energy diet develop resistance to lymphoma growth","publication_year":1993,"publication_date":"1993-03-12","ids":{"openalex":"https://openalex.org/W2032397902","doi":"https://doi.org/10.1002/ijc.2910530523","mag":"2032397902","pmid":"https://pubmed.ncbi.nlm.nih.gov/8449610"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910530523","doi":"https://doi.org/10.1002/ijc.2910530523","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910530523","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111640591","display_name":"Raphael Sharon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Raphael Sharon","raw_affiliation_strings":["Blood Bank, Hadassah University Hospital, Mount Scopus, Jerusalem","Blood Bank, Hadasssah University Hospital, Mount Scopus, Jerusalem","Dr. Sharon was killed in an accident on his way to carry out a humanitarian medical mission in Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Bank, Hadassah University Hospital, Mount Scopus, Jerusalem","institution_ids":["https://openalex.org/I2799899409"]},{"raw_affiliation_string":"Blood Bank, Hadasssah University Hospital, Mount Scopus, Jerusalem","institution_ids":["https://openalex.org/I2799899409"]},{"raw_affiliation_string":"Dr. Sharon was killed in an accident on his way to carry out a humanitarian medical mission in Nepal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068809267","display_name":"Graciela Pillemer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Graciela Pillemer","raw_affiliation_strings":["The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088791769","display_name":"Dvorah Ish\u2010Shalom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dvorah Ish\u2010Shalom","raw_affiliation_strings":["The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049705828","display_name":"Rony Kalman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rony Kalman","raw_affiliation_strings":["Department of Physiology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111621030","display_name":"Ehud Ziv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ehud Ziv","raw_affiliation_strings":["Diabetes Unit, Division of Internal Medicine, Hadassah University Hospital, Hadassah Medical School, Jerusalem 91010, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Unit, Division of Internal Medicine, Hadassah University Hospital, Hadassah Medical School, Jerusalem 91010, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040623961","display_name":"Elliot M. Berry","orcid":"https://orcid.org/0000-0002-6633-4367","observed_orcids":["https://orcid.org/0000-0002-6633-4367"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Elliot M. Berry","raw_affiliation_strings":["Division of Internal Medicine, and Department of Human Nutrition and Metabolism, Hebrew University, Hadassah Medical School, Jerusalem 91010, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, and Department of Human Nutrition and Metabolism, Hebrew University, Hadassah Medical School, Jerusalem 91010, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077047953","display_name":"David Naor","orcid":"https://orcid.org/0000-0002-2965-5399","observed_orcids":["https://orcid.org/0000-0002-2965-5399"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"David Naor","raw_affiliation_strings":["The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Hadassah Medical School, Jerusalem 91010, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077047953"],"corresponding_institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.1287,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.39041713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"53","issue":"5","first_page":"843","last_page":"849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.05790000036358833,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.049400001764297485,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-dependence","display_name":"insulin dependence","score":0.8349999785423279},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/insulin-deficiency","display_name":"insulin deficiency","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.7400000095367432},{"id":"https://openalex.org/keywords/low-calorie-diet","display_name":"hypocaloric diet","score":0.9039999842643738},{"id":"https://openalex.org/keywords/b-cell-leukemia","display_name":"B-cell leukemia","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7181432843208313},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6902732849121094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6750338673591614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6547647714614868},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6366121172904968},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5847670435905457},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.528558611869812},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5279452204704285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44867467880249023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3291979432106018},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910530523","doi":"https://doi.org/10.1002/ijc.2910530523","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910530523","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:8449610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8449610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306659","display_name":"Concern Foundation","ror":"https://ror.org/01hwjc346"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W325120064","https://openalex.org/W1625234082","https://openalex.org/W1660492880","https://openalex.org/W1672662520","https://openalex.org/W1834506923","https://openalex.org/W1898542625","https://openalex.org/W1971349727","https://openalex.org/W1971381858","https://openalex.org/W1984486816","https://openalex.org/W1984532045","https://openalex.org/W1985266211","https://openalex.org/W1995061364","https://openalex.org/W1999504828","https://openalex.org/W2020707154","https://openalex.org/W2031956553","https://openalex.org/W2100577980","https://openalex.org/W2102148982","https://openalex.org/W2104168724","https://openalex.org/W2109685961","https://openalex.org/W2120810296","https://openalex.org/W2132451696","https://openalex.org/W2148069917","https://openalex.org/W2154223536","https://openalex.org/W2296981264","https://openalex.org/W2315088565","https://openalex.org/W2970850094","https://openalex.org/W4230528518"],"related_works":["https://openalex.org/W1984486816","https://openalex.org/W7095589173","https://openalex.org/W2154223536","https://openalex.org/W2005419748","https://openalex.org/W1660492880","https://openalex.org/W2030801232","https://openalex.org/W7096036910","https://openalex.org/W1644928174","https://openalex.org/W7164811400","https://openalex.org/W2060279298"],"abstract_inverted_index":{"Physiological":[0],"concentrations":[1],"of":[2,9,34,76,100,114],"insulin":[3,18,29,85,126,136,159],"support":[4],"the":[5,32,77,97,112,156],"in":[6,20,37,127,165],"vitro":[7],"growth":[8,33,50,113,144],"LB":[10,35,48,101,161],"T-cell":[11,162],"lymphoma.":[12,78],"We":[13],"could":[14],"not":[15,108],"detect":[16],"similar":[17],"dependence":[19],"other":[21],"tumor":[22,70,163],"cell":[23],"lines.":[24],"This":[25],"study":[26],"reports":[27],"that":[28,158],"also":[30,139],"enhances":[31,160],"cells":[36],"vivo.":[38],"Mice":[39,129],"treated":[40],"with":[41,83,96],"Streptozotocin":[42],"(SZ)":[43],"developed":[44,68,140],"partial":[45],"resistance":[46,110,141],"to":[47,111,125,142],"lymphoma":[49,143],"and":[51,138],"they":[52],"survived":[53],"longer":[54],"(p":[55],"<":[56,153],"0.0025)":[57],"than":[58],"non-diabetic":[59,90],"mice":[60,67,81,91,106],"after":[61],"LB-cell":[62],"inoculation.":[63],"A":[64],"few":[65],"diabetic":[66,80,105],"complete":[69],"resistance,":[71],"manifested":[72],"by":[73],"total":[74],"regression":[75],"SZ-treated":[79,104],"reconstituted":[82],"external":[84],"died":[86],"as":[87,89],"fast":[88],"when":[92],"both":[93],"were":[94],"inoculated":[95],"same":[98],"number":[99],"cells.":[102],"The":[103],"did":[107],"develop":[109],"BCLI":[115],"B-cell":[116],"leukemia,":[117],"which":[118],"demonstrated":[119],"only":[120],"a":[121,131],"marginal":[122],"proliferative":[123],"response":[124],"vitro.":[128],"fed":[130],"low-energy":[132],"diet":[133],"exhibited":[134],"low":[135],"levels":[137],"(50%":[145],"survival":[146],"21":[147],"days":[148],"vs.":[149],"15":[150],"days;":[151],"p":[152],"0.0005),":[154],"supporting":[155],"concept":[157],"development":[164],"mice.":[166]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}