{"id":"https://openalex.org/W2032297596","doi":"https://doi.org/10.1371/journal.ppat.1000259","title":"A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75","display_name":"A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75","publication_year":2009,"publication_date":"2009-01-08","ids":{"openalex":"https://openalex.org/W2032297596","doi":"https://doi.org/10.1371/journal.ppat.1000259","mag":"2032297596","pmid":"https://pubmed.ncbi.nlm.nih.gov/19132083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2606027"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1000259","doi":"https://doi.org/10.1371/journal.ppat.1000259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000259","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000259&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000259&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006860079","display_name":"S. Hare","orcid":"https://orcid.org/0000-0003-2951-1595","observed_orcids":["https://orcid.org/0000-0003-2951-1595"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Hare","raw_affiliation_strings":["Division of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009298777","display_name":"Ming-Chieh Shun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Chieh Shun","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101233345","display_name":"Saumya Shree Gupta","orcid":"https://orcid.org/0009-0001-7636-1553","observed_orcids":["https://orcid.org/0009-0001-7636-1553"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saumya Shree Gupta","raw_affiliation_strings":["Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038328798","display_name":"Eugene Valkov","orcid":"https://orcid.org/0000-0002-3721-1739","observed_orcids":["https://orcid.org/0000-0002-3721-1739"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eugene Valkov","raw_affiliation_strings":["Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058005825","display_name":"Alan Engelman","orcid":"https://orcid.org/0000-0002-9709-2591","observed_orcids":["https://orcid.org/0000-0002-9709-2591"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Engelman","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043025715","display_name":"Peter Cherepanov","orcid":"https://orcid.org/0000-0002-0634-538X","observed_orcids":["https://orcid.org/0000-0002-0634-538X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter Cherepanov","raw_affiliation_strings":["Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043025715","https://openalex.org/A5058005825"],"corresponding_institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I47508984"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":9.4982,"has_fulltext":true,"cited_by_count":176,"citation_normalized_percentile":{"value":0.9874471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"e1000259","last_page":"e1000259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.47360000014305115,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.47360000014305115,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ledgf","display_name":"LEDGF","score":0.8700000047683716},{"id":"https://openalex.org/keywords/psip1","display_name":"PSIP1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/p75","display_name":"p75","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gain-of-function-mutants","display_name":"gain-of-function mutants","score":0.7049999833106995},{"id":"https://openalex.org/keywords/charge-charge-interactions","display_name":"charge-charge interactions","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.8602762222290039},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6771795153617859},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.4918065369129181},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4661247730255127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.419930636882782},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4178798794746399},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4160791337490082},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2872883975505829},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2730677127838135},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.13154298067092896}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054298","descriptor_name":"Human Immunodeficiency Virus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1000259","doi":"https://doi.org/10.1371/journal.ppat.1000259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000259","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000259&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2606027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2606027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:19132083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19132083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:sro.sussex.ac.uk:70292","doi":null,"is_oa":true,"landing_page_url":"http://sro.sussex.ac.uk/id/eprint/70292/1/document%20%283%29.pdf","pdf_url":"http://sro.sussex.ac.uk/id/eprint/70292/1/document%20%283%29.pdf","source":{"id":"https://openalex.org/S4306400129","display_name":"Sussex Research Online (University of Sussex)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I162608824","host_organization_name":"University of Sussex","host_organization_lineage":["https://openalex.org/I162608824"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.358.7204","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a9/1a/PLoS_Pathog_2009_Jan_9_5(1)_e1000259.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f37278f763ce45e297e405e097d7fdef","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f37278f763ce45e297e405e097d7fdef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 5, Iss 1, p e1000259 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148804","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Novel_Co_Crystal_Structure_Affords_the_Design_of_Gain_of_Function_Lentiviral_Integrase_Mutants_in_the_Presence_of_Modified_PSIP1_LEDGF_p75/148804","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:figshare.com:article/23448812","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/A_novel_co-crystal_structure_affords_the_design_of_gain-of-function_lentiviral_integrase_mutants_in_the_presence_of_modified_PSIP1_LEDGF_p75/23448812","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1000259","doi":"https://doi.org/10.1371/journal.ppat.1000259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000259","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000259&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G606801227","display_name":null,"funder_award_id":"AI39394","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6607683866","display_name":null,"funder_award_id":"ID23\u20101","funder_id":"https://openalex.org/F4320320887","funder_display_name":"European Synchrotron Radiation Facility"},{"id":"https://openalex.org/G7528560032","display_name":"Biochemical Mechanism of HIV DNA Integration","funder_award_id":"R01AI039394","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7541339971","display_name":"Integrase Structural Virology","funder_award_id":"R01AI070042","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000005083","display_name":"Biochemical Mechanism of HIV DNA Integration","funder_award_id":"R37AI039394","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000868151","display_name":"Molecular Basis of Viral Infectivity","funder_award_id":"T32AI007245","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032297596.pdf","grobid_xml":"https://content.openalex.org/works/W2032297596.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1174323499","https://openalex.org/W1488279264","https://openalex.org/W1546094383","https://openalex.org/W1572231208","https://openalex.org/W1602825981","https://openalex.org/W1685289055","https://openalex.org/W1958134851","https://openalex.org/W1964170347","https://openalex.org/W1966539971","https://openalex.org/W1969752722","https://openalex.org/W1973413376","https://openalex.org/W1980365766","https://openalex.org/W1983544779","https://openalex.org/W1997327174","https://openalex.org/W2001281718","https://openalex.org/W2001641653","https://openalex.org/W2001789973","https://openalex.org/W2005914057","https://openalex.org/W2006572311","https://openalex.org/W2020555083","https://openalex.org/W2021030434","https://openalex.org/W2026184248","https://openalex.org/W2026268551","https://openalex.org/W2038070445","https://openalex.org/W2038840577","https://openalex.org/W2057479340","https://openalex.org/W2059740818","https://openalex.org/W2060308438","https://openalex.org/W2060369798","https://openalex.org/W2061205853","https://openalex.org/W2078738195","https://openalex.org/W2080086650","https://openalex.org/W2082485360","https://openalex.org/W2082798259","https://openalex.org/W2083292764","https://openalex.org/W2085489729","https://openalex.org/W2088168986","https://openalex.org/W2088335428","https://openalex.org/W2094692623","https://openalex.org/W2094799740","https://openalex.org/W2097493124","https://openalex.org/W2106494657","https://openalex.org/W2107401350","https://openalex.org/W2109184569","https://openalex.org/W2109296787","https://openalex.org/W2113428012","https://openalex.org/W2113661986","https://openalex.org/W2114973232","https://openalex.org/W2115259457","https://openalex.org/W2123317697","https://openalex.org/W2136975219","https://openalex.org/W2136996190","https://openalex.org/W2137440275","https://openalex.org/W2140854337","https://openalex.org/W2141427436","https://openalex.org/W2144026217","https://openalex.org/W2144081223","https://openalex.org/W2150636142","https://openalex.org/W2156432090","https://openalex.org/W2163341755","https://openalex.org/W2329458316","https://openalex.org/W6627736052"],"related_works":["https://openalex.org/W7099149864","https://openalex.org/W2029800780","https://openalex.org/W2038028931","https://openalex.org/W2136975219","https://openalex.org/W2123317697","https://openalex.org/W2136996190","https://openalex.org/W1980365766","https://openalex.org/W7097997360","https://openalex.org/W2083292764","https://openalex.org/W2038165570"],"abstract_inverted_index":{"Lens":[0],"epithelium":[1],"derived":[2],"growth":[3],"factor":[4],"(LEDGF),":[5],"also":[6],"known":[7,84],"as":[8],"PC4":[9],"and":[10,16,44,60,65,96,112,150,198],"SFRS1":[11],"interacting":[12],"protein":[13],"1":[14],"(PSIP1)":[15],"transcriptional":[17],"co-activator":[18],"p75,":[19],"is":[20,45,107],"the":[21,33,58,73,83,92,97,105,115,120,133,155,162,192,200],"cellular":[22],"binding":[23,75],"partner":[24],"of":[25,36,67,78,94,101,109,114,141,158,172,204],"lentiviral":[26,110,127,143,195],"integrase":[27],"(IN)":[28],"proteins.":[29],"LEDGF":[30,147,184],"accounts":[31],"for":[32,47,139,151,191,202,208],"characteristic":[34,108],"propensity":[35],"Lentivirus":[37],"to":[38,168],"integrate":[39],"within":[40],"active":[41],"transcription":[42],"units":[43],"required":[46],"efficient":[48],"viral":[49],"replication.":[50,160],"We":[51,130],"now":[52],"present":[53],"a":[54,170,182],"crystal":[55],"structure":[56,81],"containing":[57],"N-terminal":[59],"catalytic":[61],"core":[62],"domains":[63],"(NTD":[64],"CCD)":[66],"HIV-2":[68],"IN":[69,74,95,174],"in":[70,148],"complex":[71],"with":[72,125,181],"domain":[76],"(IBD)":[77],"LEDGF.":[79],"The":[80],"extends":[82],"IN-LEDGF":[85,196],"interface,":[86],"elucidating":[87],"primarily":[88,176],"charge-charge":[89],"interactions":[90],"between":[91],"NTD":[93,106],"IBD.":[98],"A":[99],"constellation":[100],"acidic":[102],"residues":[103,118],"on":[104,119],"INs,":[111],"mutations":[113],"positively":[116],"charged":[117],"IBD":[121],"severely":[122],"affect":[123],"interaction":[124,197],"all":[126],"INs":[128],"tested.":[129],"show":[131],"that":[132,175],"novel":[134],"NTD-IBD":[135],"contacts":[136],"are":[137],"critical":[138],"stimulation":[140],"concerted":[142],"DNA":[144],"integration":[145],"by":[146],"vitro":[149],"its":[152],"function":[153],"during":[154],"early":[156],"steps":[157],"HIV-1":[159,173],"Furthermore,":[161],"new":[163],"structural":[164,189],"details":[165],"enabled":[166],"us":[167],"engineer":[169],"mutant":[171],"functions":[177],"only":[178],"when":[179],"presented":[180],"complementary":[183],"mutant.":[185],"These":[186],"findings":[187],"provide":[188],"basis":[190],"high":[193],"affinity":[194],"pave":[199],"way":[201],"development":[203],"LEDGF-based":[205],"targeting":[206],"technologies":[207],"gene":[209],"therapy.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
