{"id":"https://openalex.org/W2032198484","doi":"https://doi.org/10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","title":"Role of tumor suppressor genes in transplacental lung carcinogenesis","display_name":"Role of tumor suppressor genes in transplacental lung carcinogenesis","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2032198484","doi":"https://doi.org/10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","mag":"2032198484","pmid":"https://pubmed.ncbi.nlm.nih.gov/9537649"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","doi":"https://doi.org/10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111774612","display_name":"Lisa A. Rollins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Rollins","raw_affiliation_strings":["Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina 27157, USA","Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston\u2010Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina 27157, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston\u2010Salem, North Carolina","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058977741","display_name":"Sandra Leone\u2010Kabler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Leone-Kabler","raw_affiliation_strings":["Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087054051","display_name":"M. Gerard O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-9627-8431","observed_orcids":["https://orcid.org/0000-0002-9627-8431"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Gerard O'Sullivan","raw_affiliation_strings":["Department of Comparative Medicine, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032241792","display_name":"Mark Steven Miller","orcid":"https://orcid.org/0000-0003-1191-0977","observed_orcids":["https://orcid.org/0000-0003-1191-0977"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Steven Miller","raw_affiliation_strings":["Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina","Department of Cancer Biology, Bowman Gray School of Medicine, Medical Center Blvd., Winston\u2010Salem, NC 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Cancer Biology, Bowman Gray School of Medicine, Medical Center Blvd., Winston\u2010Salem, NC 27157","institution_ids":["https://openalex.org/I1282516798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032241792"],"corresponding_institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":1.6079,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83887702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"3","first_page":"177","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/transplacental-carcinogenesis","display_name":"transplacental carcinogenesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.9459999799728394},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.7789999842643738},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9610000252723694},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.9129999876022339},{"id":"https://openalex.org/keywords/kras2","display_name":"KRAS2","score":0.6340000033378601},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.7590000033378601},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.5849999785423279},{"id":"https://openalex.org/keywords/splice-site-variant","display_name":"splice site mutation","score":0.42800000309944153},{"id":"https://openalex.org/keywords/dba-2-mice","display_name":"DBA/2 mice","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8652231693267822},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7797533273696899},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6742978692054749},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6549283266067505},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5930600166320801},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5579735040664673},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.521704375743866},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5174965858459473},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.5033625960350037},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.44744637608528137},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.42895907163619995},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42103099822998047},{"id":"https://openalex.org/C64872895","wikidata":"https://www.wikidata.org/wiki/Q1361360","display_name":"Transversion","level":4,"score":0.41767412424087524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32566481828689575},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2494756281375885}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","doi":"https://doi.org/10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2744(199803)21:3<177::aid-mc5>3.0.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:9537649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9537649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4549591285","display_name":null,"funder_award_id":"R01 ES06501","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G572449272","display_name":"ONCOGENES AND TRANSPLACENTAL CARCINOGENESIS","funder_award_id":"5r01es006501-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000328302","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W143753117","https://openalex.org/W981450589","https://openalex.org/W1552426876","https://openalex.org/W1601604261","https://openalex.org/W1606893105","https://openalex.org/W1789714007","https://openalex.org/W1903563740","https://openalex.org/W1963488394","https://openalex.org/W1968675137","https://openalex.org/W1970056068","https://openalex.org/W1977636641","https://openalex.org/W1991494214","https://openalex.org/W1992773474","https://openalex.org/W1997261857","https://openalex.org/W1998778159","https://openalex.org/W1999330214","https://openalex.org/W2010161197","https://openalex.org/W2010493387","https://openalex.org/W2029080338","https://openalex.org/W2032118018","https://openalex.org/W2049085719","https://openalex.org/W2059956556","https://openalex.org/W2061582559","https://openalex.org/W2066848701","https://openalex.org/W2078569695","https://openalex.org/W2081282586","https://openalex.org/W2087404852","https://openalex.org/W2088704549","https://openalex.org/W2090025028","https://openalex.org/W2095690095","https://openalex.org/W2096215586","https://openalex.org/W2098481388","https://openalex.org/W2108745635","https://openalex.org/W2114247191","https://openalex.org/W2120607327","https://openalex.org/W2127804313","https://openalex.org/W2143588278","https://openalex.org/W2158097856","https://openalex.org/W2166469094","https://openalex.org/W2257427816","https://openalex.org/W2323520136","https://openalex.org/W2407915288","https://openalex.org/W2411608409","https://openalex.org/W2412427405","https://openalex.org/W2415753134","https://openalex.org/W2477177595","https://openalex.org/W2604338383","https://openalex.org/W2764460572","https://openalex.org/W4376596918","https://openalex.org/W6636130239"],"related_works":["https://openalex.org/W2132087000","https://openalex.org/W2104512196","https://openalex.org/W2108745635","https://openalex.org/W2012425194","https://openalex.org/W1998778159","https://openalex.org/W1981433654","https://openalex.org/W2094375600","https://openalex.org/W2109063774","https://openalex.org/W1970056068","https://openalex.org/W1977887991"],"abstract_inverted_index":{"Most":[0],"human":[1],"cancers":[2],"involve":[3],"multiple":[4],"genetic":[5,107],"changes,":[6],"including":[7],"activation":[8],"of":[9,17,20,23,32,40,57,83,86,99,117,121,126,133,138,156,184,186,197,206,216,232,237,242,247,256,271,282,293,303,312,322],"oncogenes":[10],"such":[11,27],"as":[12,28,90,92],"Ki-ras-2":[13],"(Kras2)":[14],"and":[15,30,63,136,146,170,279],"inactivation":[16,255],"any":[18],"one":[19],"a":[21,106,127,163,174,191,204,226,261,290],"number":[22],"tumor":[24,171,250,257,267],"suppressor":[25,251,258],"genes":[26,65,259],"p53":[29,62,88],"members":[31],"the":[33,54,61,87,118,139,157,187,195,210,235,275,304,316,320],"retinoblastoma":[34],"(Rb)":[35],"regulatory":[36,306],"axis.":[37],"As":[38],"part":[39],"an":[41,97],"ongoing":[42],"project":[43],"to":[44,50],"determine":[45],"how":[46],"in":[47,114,151,154,194,223,234,264,297,308,325],"utero":[48],"exposure":[49],"chemical":[51],"carcinogens":[52],"affects":[53],"molecular":[55],"pathogenesis":[56,321],"murine":[58,265],"lung":[59,71,266],"tumors,":[60],"p16Cdkn2a":[64],"were":[66],"analyzed":[67],"by":[68,142],"using":[69],"paraffin-embedded":[70],"tissues":[72],"from":[73],"mice":[74,122],"treated":[75],"transplacentally":[76,326],"with":[77,209,218,225,240,286,310],"3-methylcholanthrene.":[78],"Single-strand":[79],"conformation":[80,144],"polymorphism":[81,108,145],"analysis":[82,183,202],"exons":[84,134],"5-8":[85],"gene,":[89],"well":[91],"their":[93],"flanking":[94],"introns,":[95],"demonstrated":[96],"absence":[98,231],"mutations":[100,150,248,273],"at":[101,111,166,177,249,274],"this":[102],"gene":[103,141,277],"locus.":[104],"However,":[105],"was":[109,260],"identified":[110],"nt":[112,167],"708":[113],"intron":[115],"4":[116],"DBA/2":[119],"strain":[120],"5":[123],"bp":[124],"downstream":[125],"3'":[128],"branching-point":[129],"splice":[130],"signal.":[131],"Analysis":[132],"1":[135],"2":[137,153],"Cdkn2a":[140,276],"single-strand":[143],"sequence":[147],"analyses":[148],"revealed":[149,203],"exon":[152],"7%":[155],"tumors":[158,189,239,299,324],"examined.":[159],"Tumor":[160],"23-1":[161],"exhibited":[162,173],"CAC-->TAC":[164],"transition":[165,176],"301":[168],"(His74-->Tyr74),":[169],"36-1":[172],"GGG-->GAG":[175],"nucleotide":[178],"350":[179],"(Gly90-->Glu90).":[180],"Northern":[181],"blot":[182],"14":[185],"larger":[188,238],"showed":[190],"marked":[192],"decrease":[193],"levels":[196,281],"Rb":[198,283,305],"RNA":[199],"expression.":[200],"Immunohistochemical":[201],"spectrum":[205],"pRb":[207,222],"expression,":[208],"smaller":[211],"adenomas":[212],"showing":[213],"moderate":[214],"numbers":[215],"nuclei":[217,236],"heterogeneous":[219],"staining":[220],"for":[221,319],"contrast":[224],"highly":[227],"reduced":[228,280],"or":[229],"near-complete":[230],"expression":[233,284],"features":[241],"adenocarcinomas.":[243],"The":[244,269],"low":[245],"incidence":[246,292],"loci":[252],"suggested":[253],"that":[254,301],"late":[262],"event":[263],"pathogenesis.":[268],"identification":[270],"both":[272],"locus":[278],"combined":[285],"previous":[287],"studies":[288],"demonstrating":[289],"high":[291],"mutated":[294],"Kras2":[295],"alleles":[296],"these":[298],"implies":[300],"alterations":[302],"axis,":[307],"combination":[309],"mutation":[311],"Kras2,":[313],"may":[314],"be":[315],"preferred":[317],"pathway":[318],"pulmonary":[323],"exposed":[327],"mice.":[328]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
