{"id":"https://openalex.org/W2032181069","doi":"https://doi.org/10.1109/nebec.2014.6972740","title":"Simulating and predicting glucose response in lean and obese mice","display_name":"Simulating and predicting glucose response in lean and obese mice","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2032181069","doi":"https://doi.org/10.1109/nebec.2014.6972740","mag":"2032181069"},"language":"en","primary_location":{"id":"doi:10.1109/nebec.2014.6972740","doi":"https://doi.org/10.1109/nebec.2014.6972740","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebec.2014.6972740","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 40th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M. Brenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87547150","display_name":"Southern Illinois University Edwardsville","ror":"https://ror.org/04cqs5j56","country_code":"US","type":"education","lineage":["https://openalex.org/I2801502357","https://openalex.org/I87547150"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Brenner","raw_affiliation_strings":["Southern Illinois University Edwardsville, Edwardsville, IL, the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University Edwardsville, Edwardsville, IL, the United States","institution_ids":["https://openalex.org/I87547150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028859850","display_name":"Guim Kwon","orcid":"https://orcid.org/0000-0002-2420-9277","observed_orcids":["https://orcid.org/0000-0002-2420-9277"]},"institutions":[{"id":"https://openalex.org/I87547150","display_name":"Southern Illinois University Edwardsville","ror":"https://ror.org/04cqs5j56","country_code":"US","type":"education","lineage":["https://openalex.org/I2801502357","https://openalex.org/I87547150"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Kwon","raw_affiliation_strings":["Southern Illinois University Edwardsville, Edwardsville, IL, the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University Edwardsville, Edwardsville, IL, the United States","institution_ids":["https://openalex.org/I87547150"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. F. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87547150","display_name":"Southern Illinois University Edwardsville","ror":"https://ror.org/04cqs5j56","country_code":"US","type":"education","lineage":["https://openalex.org/I2801502357","https://openalex.org/I87547150"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. F. Lee","raw_affiliation_strings":["Southern Illinois University Edwardsville, Edwardsville, IL, the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University Edwardsville, Edwardsville, IL, the United States","institution_ids":["https://openalex.org/I87547150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074976626","display_name":"Michael S. Johns","orcid":"https://orcid.org/0000-0002-7889-2550","observed_orcids":["https://orcid.org/0000-0002-7889-2550"]},"institutions":[{"id":"https://openalex.org/I87547150","display_name":"Southern Illinois University Edwardsville","ror":"https://ror.org/04cqs5j56","country_code":"US","type":"education","lineage":["https://openalex.org/I2801502357","https://openalex.org/I87547150"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Johns","raw_affiliation_strings":["Southern Illinois University Edwardsville, Edwardsville, IL, the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University Edwardsville, Edwardsville, IL, the United States","institution_ids":["https://openalex.org/I87547150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089681996","display_name":"Nina Malik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87547150","display_name":"Southern Illinois University Edwardsville","ror":"https://ror.org/04cqs5j56","country_code":"US","type":"education","lineage":["https://openalex.org/I2801502357","https://openalex.org/I87547150"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Malik","raw_affiliation_strings":["Southern Illinois University Edwardsville, Edwardsville, IL, the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University Edwardsville, Edwardsville, IL, the United States","institution_ids":["https://openalex.org/I87547150"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87547150"],"apc_list":null,"apc_paid":null,"fwci":2.7266,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.91059147,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-pancreas","display_name":"artificial pancreas","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glucose-insulin-homeostasis","display_name":"glucose-insulin homeostasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7239999771118164},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5699999928474426},{"id":"https://openalex.org/keywords/rate-constant-estimation","display_name":"rate constant estimation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/diabetes-progression","display_name":"diabetes progression","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780353609","wikidata":"https://www.wikidata.org/wiki/Q1569064","display_name":"Artificial pancreas","level":4,"score":0.6950429677963257},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6299382448196411},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5689409375190735},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4883234202861786},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.43887490034103394},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.423638254404068},{"id":"https://openalex.org/C2779794567","wikidata":"https://www.wikidata.org/wiki/Q941674","display_name":"Insulin pump","level":4,"score":0.41454607248306274},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39559927582740784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38638171553611755},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35182371735572815},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33000779151916504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30674320459365845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3026965856552124},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.22790834307670593},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.22692081332206726}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nebec.2014.6972740","doi":"https://doi.org/10.1109/nebec.2014.6972740","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebec.2014.6972740","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 40th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2035977505","https://openalex.org/W2049859140"],"related_works":["https://openalex.org/W2621642518","https://openalex.org/W3167021188","https://openalex.org/W2395031301","https://openalex.org/W2035977505","https://openalex.org/W2071131829","https://openalex.org/W2305822942","https://openalex.org/W4232405329","https://openalex.org/W7028346917","https://openalex.org/W2732290498","https://openalex.org/W4385452255"],"abstract_inverted_index":{"Diabetes":[0],"mellitus":[1],"is":[2,86],"a":[3,114,124,241],"serious":[4],"and":[5,24,50,102,138,142,151,172,200,237],"widespread":[6],"disease":[7,36],"currently":[8],"affecting":[9],"25.8":[10],"million":[11],"people":[12],"in":[13,81,140,182,210],"the":[14,32,35,74,78,87,104,108,134,169,174,183,194,204,207,220,233],"United":[15],"States.":[16],"Its":[17],"treatments":[18],"including":[19],"exercise,":[20],"diet,":[21],"hypoglycemic":[22],"pills,":[23],"insulin":[25,96,139],"often":[26],"are":[27,229],"not":[28],"sufficient":[29],"to":[30,106,132,193,245,251],"mitigate":[31],"symptoms":[33],"of":[34,47,62,77,89,94,111,136,206,215,219,235],"or":[37],"prevent":[38],"its":[39],"progression":[40,234],"over":[41],"time.":[42],"An":[43],"artificial":[44,84,120],"pancreas":[45,85],"capable":[46,93],"continuously":[48],"monitoring":[49],"adjusting":[51],"blood":[52,99,153],"glucose":[53,63,100,137,147,154],"levels":[54,64,155],"through":[55],"closed-loop":[56],"control":[57,242],"thus":[58,238],"maintaining":[59],"optimal":[60],"range":[61],"at":[65,156,212],"all":[66],"times":[67],"will":[68],"be":[69,246],"an":[70,83,90],"ideal":[71],"treatment":[72],"for":[73,119,159,179,197,248],"disease.":[75],"One":[76],"largest":[79],"hurdles":[80],"developing":[82,117],"creation":[88],"individualized":[91],"algorithm":[92,243],"calculating":[95],"doses":[97,110],"from":[98],"readings":[101],"controlling":[103],"pump":[105],"deliver":[107],"appropriate":[109],"insulin.":[112],"As":[113],"step":[115],"toward":[116],"algorithms":[118],"pancreas,":[121],"we":[122],"adopted":[123],"mathematical":[125,170,208],"model":[126,171,209],"by":[127,232],"Lombarte":[128],"et":[129],"al.":[130],"[3]":[131],"study":[133],"homeostasis":[135],"lean":[141,199],"obese":[143,201],"mice.":[144],"We":[145,162],"administered":[146],"(1":[148],"g/kg)":[149],"intra-peritoneally":[150],"measured":[152],"various":[157,180],"intervals":[158],"120":[160],"min.":[161],"performed":[163],"simulation":[164],"using":[165,186],"ArenaTMsoftware":[166],"based":[167],"on":[168],"estimated":[173],"rate":[175,221],"constants":[176,222],"(8":[177],"parameters)":[178],"terms":[181],"differential":[184],"equations":[185],"OPtQuestTM.":[187],"The":[188],"simulated":[189],"data":[190,196],"fit":[191],"accurately":[192],"observed":[195],"both":[198],"mice,":[202],"validating":[203],"use":[205],"mice":[211],"different":[213],"stages":[214],"diabetes":[216,236],"progression.":[217],"Examination":[218],"may":[223],"provide":[224],"insights":[225],"into":[226],"which":[227],"parameters":[228,250],"mostly":[230],"affected":[231],"how":[239],"tightly":[240],"needs":[244],"calibrated":[247],"these":[249],"maintain":[252],"proper":[253],"control.":[254]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}