{"id":"https://openalex.org/W2032064883","doi":"https://doi.org/10.1002/cmdc.201000395","title":"Strategies towards Improving the Pharmacokinetic Profile of \u03b5\u2010Substituted Lysinol\u2010Derived HIV Protease Inhibitors","display_name":"Strategies towards Improving the Pharmacokinetic Profile of \u03b5\u2010Substituted Lysinol\u2010Derived HIV Protease Inhibitors","publication_year":2010,"publication_date":"2010-12-29","ids":{"openalex":"https://openalex.org/W2032064883","doi":"https://doi.org/10.1002/cmdc.201000395","mag":"2032064883","pmid":"https://pubmed.ncbi.nlm.nih.gov/21275047"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201000395","doi":"https://doi.org/10.1002/cmdc.201000395","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201000395","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001640378","display_name":"Hemaka A. Rajapakse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hemaka A. Rajapakse","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486, USA. hemaka_rajapakse@merck.com","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486, USA. hemaka_rajapakse@merck.com","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075023993","display_name":"Abbas M. Walji","orcid":"https://orcid.org/0000-0001-9953-136X","observed_orcids":["https://orcid.org/0000-0001-9953-136X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abbas M. Walji","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027627345","display_name":"Keith P. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith P. Moore","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102447301","display_name":"Hong Zhu","orcid":"https://orcid.org/0009-0004-9806-229X","observed_orcids":["https://orcid.org/0009-0004-9806-229X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Zhu","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007443445","display_name":"Aurpon W. Mitra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aurpon W. Mitra","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000184474","display_name":"Alison R. Gregro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison R. Gregro","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049010015","display_name":"Elizabeth Tinney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Tinney","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085651304","display_name":"Christine Burlein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Burlein","raw_affiliation_strings":["Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041582989","display_name":"Sinoeun Touch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sinoeun Touch","raw_affiliation_strings":["Department of Vaccine Basic Research, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vaccine Basic Research, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brenda L. Paton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda L. Paton","raw_affiliation_strings":["Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023534006","display_name":"Steven S. Carroll","orcid":"https://orcid.org/0000-0002-9044-9770","observed_orcids":["https://orcid.org/0000-0002-9044-9770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven S. Carroll","raw_affiliation_strings":["Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113519167","display_name":"Daniel J. DiStefano","orcid":"https://orcid.org/0000-0003-4206-6799","observed_orcids":["https://orcid.org/0000-0003-4206-6799"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. DiStefano","raw_affiliation_strings":["Department of Vaccine Basic Research, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vaccine Basic Research, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103466467","display_name":"Ming\u2010Tain Lai","orcid":"https://orcid.org/0000-0002-9829-7943","observed_orcids":["https://orcid.org/0000-0002-9829-7943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming\u2010Tain Lai","raw_affiliation_strings":["Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111431382","display_name":"Jay A. Grobler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay A. Grobler","raw_affiliation_strings":["Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antiviral Research, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109398557","display_name":"Rosa I. S\u00e1nchez","orcid":"https://orcid.org/0000-0002-5348-2432","observed_orcids":["https://orcid.org/0000-0002-5348-2432"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa I. Sanchez","raw_affiliation_strings":["Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA)","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103854352","display_name":"Theresa M. Williams","orcid":"https://orcid.org/0009-0006-0197-1521","observed_orcids":["https://orcid.org/0009-0006-0197-1521"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa M. Williams","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112471086","display_name":"Joseph P. Vacca","orcid":"https://orcid.org/0000-0003-0794-1527","observed_orcids":["https://orcid.org/0000-0003-0794-1527"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. Vacca","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065727643","display_name":"Philippe G. Nantermet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippe G. Nantermet","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA),","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486 (USA), Fax: (+1)\u2009215\u2010652\u20105629","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001640378"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.2122,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58691309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"6","issue":"2","first_page":"253","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-protease-inhibitors","display_name":"HIV protease inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pharmacokinetic-properties","display_name":"pharmacokinetic properties","score":0.640999972820282},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9160000085830688},{"id":"https://openalex.org/keywords/antiretroviral-drug-design","display_name":"antiretroviral drug design","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7212256193161011},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.6493085026741028},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6353172063827515},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5986630320549011},{"id":"https://openalex.org/C106195933","wikidata":"https://www.wikidata.org/wiki/Q7847935","display_name":"Truncation (statistics)","level":2,"score":0.4889909029006958},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4499802887439728},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.44359737634658813},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4048532247543335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3713300824165344},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33698445558547974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33183830976486206},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2819288969039917},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.22200343012809753},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20737344026565552},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2041548192501068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19742360711097717},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1567847728729248},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0809989869594574}],"mesh":[{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cmdc.201000395","doi":"https://doi.org/10.1002/cmdc.201000395","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201000395","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:21275047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21275047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1997595536","https://openalex.org/W2005644558","https://openalex.org/W2012849897","https://openalex.org/W2035095394","https://openalex.org/W2048393533","https://openalex.org/W2051371294","https://openalex.org/W2105946373","https://openalex.org/W2125054595","https://openalex.org/W2132185205","https://openalex.org/W2167879129","https://openalex.org/W2318289184","https://openalex.org/W2953316262","https://openalex.org/W3149136819"],"related_works":["https://openalex.org/W2125054595","https://openalex.org/W2953254802","https://openalex.org/W1986127391","https://openalex.org/W2951553557","https://openalex.org/W2073251219","https://openalex.org/W2055972874","https://openalex.org/W2144464230","https://openalex.org/W2951969580","https://openalex.org/W2176268338","https://openalex.org/W7043792267"],"abstract_inverted_index":{"Compounds":[0],"that":[1],"are":[2],"all":[3],"HAART:":[4],"Subsequent":[5],"to":[6],"accessing":[7],"the":[8,15,40,44,48,58],"S2":[9],"subpocket":[10,46],"of":[11,19,39,50,61],"HIV":[12,20],"protease":[13,21],"from":[14],"novel":[16],"lysinol":[17],"series":[18],"inhibitors,":[22],"we":[23],"now":[24],"report":[25],"a":[26],"comprehensive":[27],"structure\u2013activity":[28],"relationship":[29],"study":[30],"at":[31],"this":[32],"position.":[33],"Balancing":[34],"physical":[35],"properties":[36],"via":[37],"truncation":[38],"substituent":[41],"binding":[42],"in":[43],"S1\u2032":[45],"enabled":[47],"discovery":[49],"inhibitors":[51],"with":[52],"improved":[53],"pharmacokinetic":[54],"properties,":[55],"while":[56],"maintaining":[57],"functional":[59],"potency":[60],"these":[62],"inhibitors.":[63]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}