{"id":"https://openalex.org/W2032045112","doi":"https://doi.org/10.1371/journal.pone.0019743","title":"Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells","display_name":"Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells","publication_year":2011,"publication_date":"2011-05-16","ids":{"openalex":"https://openalex.org/W2032045112","doi":"https://doi.org/10.1371/journal.pone.0019743","mag":"2032045112","pmid":"https://pubmed.ncbi.nlm.nih.gov/21603572","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3095638"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0019743","doi":"https://doi.org/10.1371/journal.pone.0019743","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0019743","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019743&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019743&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003032786","display_name":"Athanasia D. Panopoulos","orcid":"https://orcid.org/0000-0002-9610-2604","observed_orcids":["https://orcid.org/0000-0002-9610-2604"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Athanasia D. Panopoulos","raw_affiliation_strings":["Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051333971","display_name":"Sergio Ruiz","orcid":"https://orcid.org/0000-0002-0177-6965","observed_orcids":["https://orcid.org/0000-0002-0177-6965","https://orcid.org/0009-0005-1147-2200"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Ruiz","raw_affiliation_strings":["America","Gene Expression Laboratory, The Salk Institute","for Biological Studies, La Jolla, California, United States of","Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"America","institution_ids":[]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"for Biological Studies, La Jolla, California, United States of","institution_ids":[]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036770398","display_name":"Fei Yi","orcid":"https://orcid.org/0000-0002-2464-3655","observed_orcids":["https://orcid.org/0000-0002-2464-3655"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Yi","raw_affiliation_strings":["America","Gene Expression Laboratory, The Salk Institute","for Biological Studies, La Jolla, California, United States of","Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"America","institution_ids":[]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"for Biological Studies, La Jolla, California, United States of","institution_ids":[]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032764901","display_name":"Aida Herrerias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138155","display_name":"Center of Regenerative Medicine in Barcelona","ror":"https://ror.org/03q0p7c86","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138155","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A\u00edda Herrer\u00edas","raw_affiliation_strings":["Barcelona, Spain","Center of Regenerative Medicine in Barcelona","Center of Regenerative Medicine in Barcelona,\n                    Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona, Spain","institution_ids":[]},{"raw_affiliation_string":"Center of Regenerative Medicine in Barcelona","institution_ids":["https://openalex.org/I4210138155"]},{"raw_affiliation_string":"Center of Regenerative Medicine in Barcelona,\n                    Barcelona, Spain","institution_ids":["https://openalex.org/I4210138155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034335324","display_name":"Erika M. Batchelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika M. Batchelder","raw_affiliation_strings":["America","Gene Expression Laboratory, The Salk Institute","for Biological Studies, La Jolla, California, United States of","Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"America","institution_ids":[]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"for Biological Studies, La Jolla, California, United States of","institution_ids":[]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050690657","display_name":"Juan Carlos Izpis\u00faa Belmonte","orcid":"https://orcid.org/0000-0003-0557-8875","observed_orcids":["https://orcid.org/0000-0003-0557-8875"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I4210138155","display_name":"Center of Regenerative Medicine in Barcelona","ror":"https://ror.org/03q0p7c86","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138155","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Juan Carlos Izpisua Belmonte","raw_affiliation_strings":["America","Barcelona, Spain","Center of Regenerative Medicine in Barcelona","Gene Expression Laboratory, The Salk Institute","for Biological Studies, La Jolla, California, United States of","Center of Regenerative Medicine in Barcelona,\n                    Barcelona, Spain","Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"America","institution_ids":[]},{"raw_affiliation_string":"Barcelona, Spain","institution_ids":[]},{"raw_affiliation_string":"Center of Regenerative Medicine in Barcelona","institution_ids":["https://openalex.org/I4210138155"]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"for Biological Studies, La Jolla, California, United States of","institution_ids":[]},{"raw_affiliation_string":"Center of Regenerative Medicine in Barcelona,\n                    Barcelona, Spain","institution_ids":["https://openalex.org/I4210138155"]},{"raw_affiliation_string":"Gene Expression Laboratory, The Salk Institute\n                    for Biological Studies, La Jolla, California, United States of\n                    America","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050690657"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I4210138155"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.724,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.90834609,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"e19743","last_page":"e19743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":1.0},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/somatic-cell-reprogramming","display_name":"somatic cell reprogramming","score":0.9860000014305115},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.6140000224113464},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tgf-beta-inhibition","display_name":"TGF-beta inhibition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/reprogramming-efficiency","display_name":"reprogramming efficiency","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/germ-layer-differentiation","display_name":"germ layer differentiation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9024926424026489},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8377177715301514},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.7110952138900757},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6917198896408081},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6556039452552795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6426215171813965},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6272002458572388},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5409427881240845},{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.4536839723587036},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.43968063592910767},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.324336975812912},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25509005784988403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13820910453796387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0019743","doi":"https://doi.org/10.1371/journal.pone.0019743","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0019743","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019743&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3095638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3095638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21603572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21603572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8a5f131296cc43adbe9e7dc0c1806d5f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8a5f131296cc43adbe9e7dc0c1806d5f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 5, p e19743 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0019743","doi":"https://doi.org/10.1371/journal.pone.0019743","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0019743","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019743&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000866935","display_name":"Cancer Heterogeneity, Immunity, and Microenvironment (CHIME) Training Program","funder_award_id":"T32CA009370","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032045112.pdf","grobid_xml":"https://content.openalex.org/works/W2032045112.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1967049808","https://openalex.org/W1981809048","https://openalex.org/W1991936258","https://openalex.org/W1994142477","https://openalex.org/W2002943691","https://openalex.org/W2006557127","https://openalex.org/W2030173131","https://openalex.org/W2030299771","https://openalex.org/W2038723730","https://openalex.org/W2043457504","https://openalex.org/W2043497619","https://openalex.org/W2047463251","https://openalex.org/W2059223857","https://openalex.org/W2073610802","https://openalex.org/W2079695054","https://openalex.org/W2086943348","https://openalex.org/W2087137170","https://openalex.org/W2096216062","https://openalex.org/W2108992451","https://openalex.org/W2119109414","https://openalex.org/W2125987139","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2143495094","https://openalex.org/W2151220680","https://openalex.org/W2154029502","https://openalex.org/W2160220798","https://openalex.org/W2169725989"],"related_works":["https://openalex.org/W7098568189","https://openalex.org/W2612547471","https://openalex.org/W2498792073","https://openalex.org/W2143495094","https://openalex.org/W1933481293","https://openalex.org/W2111951272","https://openalex.org/W7100557501","https://openalex.org/W2767743827","https://openalex.org/W2094943622","https://openalex.org/W2001246435"],"abstract_inverted_index":{"The":[0,148],"ability":[1,136],"to":[2,6,64,129,137],"induce":[3],"somatic":[4,32,62,176],"cells":[5,40,47,118,126,173],"pluripotency":[7],"by":[8,162],"ectopic":[9],"expression":[10],"of":[11,26,35,54,102,154],"defined":[12],"transcription":[13],"factors":[14],"(e.g.":[15],"KLF-4,":[16],"OCT4,":[17],"SOX2,":[18],"c-MYC,":[19],"or":[20],"KOSM)":[21],"has":[22],"transformed":[23],"the":[24,49,55,100,160,184],"future":[25],"regenerative":[27],"medicine.":[28],"Here":[29],"we":[30],"report":[31],"cell":[33,63,69,156],"reprogramming":[34,57,88,93,185],"human":[36,61,122],"umbilical":[37],"vein":[38],"endothelial":[39],"(HUVECs),":[41],"yielding":[42],"induced":[43],"pluripotent":[44,131],"stem":[45,124],"(iPS)":[46],"with":[48,85,127,159],"fastest":[50],"kinetics,":[51],"and":[52,82,134,145,151,169,181],"one":[53],"highest":[56],"efficiencies":[58],"for":[59,178,182],"a":[60,78,86,103],"date.":[65],"HUVEC-derived":[66],"iPS":[67],"(Huv-iPS)":[68],"colonies":[70],"appeared":[71],"as":[72,74],"early":[73],"6":[75],"days":[76],"after":[77],"single":[79],"KOSM":[80],"infection,":[81],"were":[83,119],"generated":[84],"2.5-3%":[87],"efficiency.":[89],"Furthermore,":[90],"when":[91],"HUVEC":[92],"was":[94],"performed":[95],"under":[96],"hypoxic":[97],"conditions":[98],"in":[99,143,146],"presence":[101],"TGF-beta":[104],"family":[105],"signaling":[106],"inhibitor,":[107],"colony":[108],"formation":[109],"increased":[110],"an":[111,174],"additional":[112],"\u223c2.5-fold":[113],"over":[114],"standard":[115],"conditions.":[116],"Huv-iPS":[117,155],"indistinguishable":[120],"from":[121],"embryonic":[123,140],"(ES)":[125],"regards":[128],"morphology,":[130],"marker":[132],"expression,":[133],"their":[135],"generate":[138],"all":[139],"germ":[141],"layers":[142],"vitro":[144],"vivo.":[147],"high":[149],"efficiency":[150],"rapid":[152],"kinetics":[153],"formation,":[157],"coupled":[158],"ease":[161],"which":[163],"HUVECs":[164],"can":[165],"be":[166],"collected,":[167],"expanded":[168],"stored,":[170],"make":[171],"these":[172],"attractive":[175],"source":[177],"therapeutic":[179],"application,":[180],"studying":[183],"process.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}