{"id":"https://openalex.org/W2032012179","doi":"https://doi.org/10.1016/0167-4838(90)90278-n","title":"Proton nuclear magnetic resonance study of human interleukin 6: Chemical modifications and partial spectral assignments for the aromatic residues","display_name":"Proton nuclear magnetic resonance study of human interleukin 6: Chemical modifications and partial spectral assignments for the aromatic residues","publication_year":1990,"publication_date":"1990-12-01","ids":{"openalex":"https://openalex.org/W2032012179","doi":"https://doi.org/10.1016/0167-4838(90)90278-n","mag":"2032012179","pmid":"https://pubmed.ncbi.nlm.nih.gov/2268669"},"language":"en","primary_location":{"id":"doi:10.1016/0167-4838(90)90278-n","doi":"https://doi.org/10.1016/0167-4838(90)90278-n","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4838(90)90278-n","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085160955","display_name":"Chiaki Nishimura","orcid":"https://orcid.org/0000-0001-8417-3328","observed_orcids":["https://orcid.org/0000-0001-8417-3328"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiaki Nishimura","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081118215","display_name":"Hiroyuki Hanzawa","orcid":"https://orcid.org/0000-0002-0471-7936","observed_orcids":["https://orcid.org/0000-0002-0471-7936"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Hanzawa","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050843806","display_name":"Shun-ichi Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59814707","display_name":"Tosoh (Japan)","ror":"https://ror.org/05efy4j44","country_code":"JP","type":"company","lineage":["https://openalex.org/I59814707"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun-ichi Itoh","raw_affiliation_strings":["Tosoh Corporation, Ayase-shi, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tosoh Corporation, Ayase-shi, Kanagawa, Japan","institution_ids":["https://openalex.org/I59814707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029914339","display_name":"Kiyoshi Yasukawa","orcid":"https://orcid.org/0000-0001-7748-6043","observed_orcids":["https://orcid.org/0000-0001-7748-6043"]},"institutions":[{"id":"https://openalex.org/I59814707","display_name":"Tosoh (Japan)","ror":"https://ror.org/05efy4j44","country_code":"JP","type":"company","lineage":["https://openalex.org/I59814707"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Yasukawa","raw_affiliation_strings":["Tosoh Corporation, Ayase-shi, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tosoh Corporation, Ayase-shi, Kanagawa, Japan","institution_ids":["https://openalex.org/I59814707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027810994","display_name":"Ichio Shimada","orcid":"https://orcid.org/0000-0001-9864-3407","observed_orcids":["https://orcid.org/0000-0001-9864-3407"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichio Shimada","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021463605","display_name":"Tadamitsu Kishimoto","orcid":"https://orcid.org/0000-0002-7862-154X","observed_orcids":["https://orcid.org/0000-0002-7862-154X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadamitsu Kishimoto","raw_affiliation_strings":["Institute for Molecular and Cellular Biology, Osaka University, Suita City, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular and Cellular Biology, Osaka University, Suita City, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113495654","display_name":"Yoji Arata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Arata","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8184,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81820602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1041","issue":"3","first_page":"243","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9769999980926514},{"id":"https://openalex.org/keywords/aromatic-residues","display_name":"aromatic residues","score":0.8619999885559082},{"id":"https://openalex.org/keywords/1h-nmr-resonance-assignment","display_name":"1H NMR resonance assignment","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange","display_name":"hydrogen-deuterium exchange","score":0.7649999856948853},{"id":"https://openalex.org/keywords/iodination","display_name":"iodination","score":0.45899999141693115},{"id":"https://openalex.org/keywords/tyrosine","display_name":"tyrosine","score":0.5249999761581421},{"id":"https://openalex.org/keywords/histidine","display_name":"histidine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":1.0},{"id":"https://openalex.org/keywords/solvent-accessibility","display_name":"solvent accessibility","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dynamic-nuclear-polarization","display_name":"dynamic nuclear polarization","score":0.6129999756813049},{"id":"https://openalex.org/keywords/chemical-modification","display_name":"chemical modification","score":0.5339999794960022},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C40447573","wikidata":"https://www.wikidata.org/wiki/Q5891521","display_name":"Homonuclear molecule","level":3,"score":0.7511587738990784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7394871115684509},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.708982527256012},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6852056980133057},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.6625427603721619},{"id":"https://openalex.org/C2780874372","wikidata":"https://www.wikidata.org/wiki/Q328692","display_name":"Imidazole","level":2,"score":0.6305780410766602},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.46573320031166077},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.45639464259147644},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.4527481198310852},{"id":"https://openalex.org/C139210041","wikidata":"https://www.wikidata.org/wiki/Q2145840","display_name":"Resonance (particle physics)","level":2,"score":0.4474067687988281},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.41190627217292786},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.39701366424560547},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23415210843086243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17425858974456787},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13615629076957703},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.11208879947662354},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C109214941","wikidata":"https://www.wikidata.org/wiki/Q18334","display_name":"Particle physics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0167-4838(90)90278-n","doi":"https://doi.org/10.1016/0167-4838(90)90278-n","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4838(90)90278-n","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},{"id":"pmid:2268669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2268669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W42260490","https://openalex.org/W150662395","https://openalex.org/W1585178517","https://openalex.org/W1616501289","https://openalex.org/W1903887594","https://openalex.org/W1972155218","https://openalex.org/W1974652824","https://openalex.org/W1983224547","https://openalex.org/W1990639352","https://openalex.org/W1993499734","https://openalex.org/W1993844842","https://openalex.org/W1996548067","https://openalex.org/W2001126115","https://openalex.org/W2002076761","https://openalex.org/W2002744092","https://openalex.org/W2014550271","https://openalex.org/W2022881613","https://openalex.org/W2040020188","https://openalex.org/W2045590518","https://openalex.org/W2061854154","https://openalex.org/W2067127132","https://openalex.org/W2084386397","https://openalex.org/W2094989950","https://openalex.org/W2128873996","https://openalex.org/W2169046469","https://openalex.org/W2220554922"],"related_works":["https://openalex.org/W7097790575","https://openalex.org/W1893200263","https://openalex.org/W2183846827","https://openalex.org/W6996757472","https://openalex.org/W2118018298","https://openalex.org/W2053295610","https://openalex.org/W2056310181","https://openalex.org/W1985021029","https://openalex.org/W7100126990","https://openalex.org/W3111223584"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}