{"id":"https://openalex.org/W2031990959","doi":"https://doi.org/10.1016/j.bbrc.2005.11.158","title":"Prion protein induced signaling cascades in monocytes","display_name":"Prion protein induced signaling cascades in monocytes","publication_year":2005,"publication_date":"2005-12-07","ids":{"openalex":"https://openalex.org/W2031990959","doi":"https://doi.org/10.1016/j.bbrc.2005.11.158","mag":"2031990959","pmid":"https://pubmed.ncbi.nlm.nih.gov/16343423"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2005.11.158","doi":"https://doi.org/10.1016/j.bbrc.2005.11.158","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2005.11.158","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082070807","display_name":"Bjarne Krebs","orcid":"https://orcid.org/0009-0001-9493-8803","observed_orcids":["https://orcid.org/0009-0001-9493-8803"]},"institutions":[{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bjarne Krebs","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023261190","display_name":"Cornelia Dorner\u2010Ciossek","orcid":"https://orcid.org/0009-0004-7375-4724","observed_orcids":["https://orcid.org/0009-0004-7375-4724"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Dorner-Ciossek","raw_affiliation_strings":["CNS Research III, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach/Riss, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS Research III, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach/Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015478485","display_name":"R\u00fcdiger Schmalzbauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R\u00fcdiger Schmalzbauer","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082332849","display_name":"Neville Vassallo","orcid":"https://orcid.org/0000-0002-8985-5587","observed_orcids":["https://orcid.org/0000-0002-8985-5587"]},"institutions":[{"id":"https://openalex.org/I197854408","display_name":"University of Malta","ror":"https://ror.org/03a62bv60","country_code":"MT","type":"education","lineage":["https://openalex.org/I197854408"]}],"countries":["MT"],"is_corresponding":false,"raw_author_name":"Neville Vassallo","raw_affiliation_strings":["Department of Physiology and Biochemistry, University of Malta, Msida, Malta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biochemistry, University of Malta, Msida, Malta","institution_ids":["https://openalex.org/I197854408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069184646","display_name":"Jochen Wolfgang Herms","orcid":"https://orcid.org/0000-0002-6201-1042","observed_orcids":["https://orcid.org/0000-0002-6201-1042"]},"institutions":[{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Herms","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103372260","display_name":"Hans A. Kretzschmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans A. Kretzschmar","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103372260"],"corresponding_institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.9616,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.85152178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"340","issue":"1","first_page":"13","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-prion-protein","display_name":"cellular prion protein","score":0.9739999771118164},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.699999988079071},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/akt-kinase","display_name":"Akt kinase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.6600822806358337},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5675045847892761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5056219100952148},{"id":"https://openalex.org/C2994130171","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Signaling proteins","level":3,"score":0.48130002617836},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4239780306816101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3368992209434509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1046018898487091},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09776419401168823},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2005.11.158","doi":"https://doi.org/10.1016/j.bbrc.2005.11.158","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2005.11.158","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:16343423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16343423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W11571277","https://openalex.org/W36603652","https://openalex.org/W53055727","https://openalex.org/W1504399240","https://openalex.org/W1509361070","https://openalex.org/W1552779466","https://openalex.org/W1571287379","https://openalex.org/W1662968076","https://openalex.org/W1882941126","https://openalex.org/W1954929088","https://openalex.org/W1973740278","https://openalex.org/W1977523984","https://openalex.org/W1978283620","https://openalex.org/W1978523429","https://openalex.org/W1979617068","https://openalex.org/W1982720718","https://openalex.org/W1984944464","https://openalex.org/W1989409992","https://openalex.org/W1990496336","https://openalex.org/W1991825117","https://openalex.org/W1997259637","https://openalex.org/W1997725693","https://openalex.org/W1998509304","https://openalex.org/W1999788892","https://openalex.org/W2004093049","https://openalex.org/W2005519900","https://openalex.org/W2008004502","https://openalex.org/W2011032265","https://openalex.org/W2011927539","https://openalex.org/W2013679718","https://openalex.org/W2018290520","https://openalex.org/W2020830047","https://openalex.org/W2024717330","https://openalex.org/W2031682941","https://openalex.org/W2032735666","https://openalex.org/W2032860676","https://openalex.org/W2034064964","https://openalex.org/W2043028254","https://openalex.org/W2044296969","https://openalex.org/W2046583364","https://openalex.org/W2046633236","https://openalex.org/W2053636966","https://openalex.org/W2063880942","https://openalex.org/W2066560193","https://openalex.org/W2071041511","https://openalex.org/W2077289389","https://openalex.org/W2079051863","https://openalex.org/W2080514032","https://openalex.org/W2081852339","https://openalex.org/W2084646890","https://openalex.org/W2094279987","https://openalex.org/W2098103936","https://openalex.org/W2115654943","https://openalex.org/W2117064662","https://openalex.org/W2117711773","https://openalex.org/W2118510702","https://openalex.org/W2119616506","https://openalex.org/W2121737241","https://openalex.org/W2128057594","https://openalex.org/W2132905193","https://openalex.org/W2133198589","https://openalex.org/W2133527571","https://openalex.org/W2135237151","https://openalex.org/W2144516044","https://openalex.org/W2147465611","https://openalex.org/W2147987476","https://openalex.org/W2150030958","https://openalex.org/W2150497169","https://openalex.org/W2150824641","https://openalex.org/W2151352928","https://openalex.org/W2159005114","https://openalex.org/W2165212681","https://openalex.org/W2167842421","https://openalex.org/W2324660492","https://openalex.org/W3027589959"],"related_works":["https://openalex.org/W2029953489","https://openalex.org/W2110029042","https://openalex.org/W2407946980","https://openalex.org/W2080514032","https://openalex.org/W2094669310","https://openalex.org/W1987173512","https://openalex.org/W2020066220","https://openalex.org/W1972279798","https://openalex.org/W2150030958","https://openalex.org/W2136564147"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
