{"id":"https://openalex.org/W2031900304","doi":"https://doi.org/10.1038/sj.bjc.6690537","title":"PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma","display_name":"PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma","publication_year":1999,"publication_date":"1999-06-11","ids":{"openalex":"https://openalex.org/W2031900304","doi":"https://doi.org/10.1038/sj.bjc.6690537","mag":"2031900304","pmid":"https://pubmed.ncbi.nlm.nih.gov/10424744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363077"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6690537","doi":"https://doi.org/10.1038/sj.bjc.6690537","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6690537","pdf_url":"https://www.nature.com/articles/6690537.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6690537.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004019711","display_name":"Christian Simon","orcid":"https://orcid.org/0000-0002-4156-9143","observed_orcids":["https://orcid.org/0000-0002-4156-9143"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Simon","raw_affiliation_strings":["Department of Head and Neck Surgery, The University of Texas, MD Anderson Cancer Center, Houston 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, The University of Texas, MD Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035391539","display_name":"John M. Hicks","orcid":"https://orcid.org/0000-0002-1464-3803","observed_orcids":["https://orcid.org/0000-0002-1464-3803"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Hicks","raw_affiliation_strings":["Department of Pathology, Texas Children\u2019s Hospital and Baylor College of Medicine, Houston, TX, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Texas Children\u2019s Hospital and Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015308351","display_name":"Andrew J. Nemechek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A J Nemechek","raw_affiliation_strings":["Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036412023","display_name":"Rohtesh S. Mehta","orcid":"https://orcid.org/0000-0002-8532-544X","observed_orcids":["https://orcid.org/0000-0002-8532-544X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Mehta","raw_affiliation_strings":["Departments of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","Departments of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Departments of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B W O\u2019Malley Jr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B W O\u2019Malley Jr","raw_affiliation_strings":["Department of Otolaryngology \u2013 Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology \u2013 Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015488796","display_name":"Helmuth Goepfert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Goepfert","raw_affiliation_strings":["Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108382526","display_name":"Catherine M. Flaitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Flaitz","raw_affiliation_strings":["University of Texas \u2013 Dental Branch, Houston, TX, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas \u2013 Dental Branch, Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084442354","display_name":"Douglas D. Boyd","orcid":"https://orcid.org/0000-0002-1380-402X","observed_orcids":["https://orcid.org/0000-0002-1380-402X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Boyd","raw_affiliation_strings":["Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","Cancer Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Cancer Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.9771,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.72321535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"80","issue":"9","first_page":"1412","last_page":"1419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.2919999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.824999988079071},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumour-invasiveness","display_name":"tumour invasiveness","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.7319999933242798},{"id":"https://openalex.org/keywords/type-iv-collagenase","display_name":"type IV collagenase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.6949999928474426},{"id":"https://openalex.org/keywords/bone-invasion","display_name":"bone invasion","score":0.796999990940094},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.48500001430511475},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.6309999823570251},{"id":"https://openalex.org/keywords/mylohyoid-muscle","display_name":"mylohyoid muscle","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7009989619255066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.635562002658844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5438043475151062},{"id":"https://openalex.org/C2778670693","wikidata":"https://www.wikidata.org/wiki/Q580326","display_name":"Genioglossus","level":3,"score":0.4720374345779419},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4255143105983734},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41940295696258545},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3742898106575012},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.289494127035141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22535467147827148},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015060","descriptor_name":"1,2-Dipalmitoylphosphatidylcholine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/sj.bjc.6690537","doi":"https://doi.org/10.1038/sj.bjc.6690537","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6690537","pdf_url":"https://www.nature.com/articles/6690537.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1505745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2363077","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363077","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:10424744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10424744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.8143","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.8143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/db/7e/Br_J_Cancer_1999_Jul_80(9)_1412-1419.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6690537","doi":"https://doi.org/10.1038/sj.bjc.6690537","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6690537","pdf_url":"https://www.nature.com/articles/6690537.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7180995546","display_name":"NOVEL DIAGNOSIS AND THERAPY OF EARLY ORAL CANCERS","funder_award_id":"P50DE011906","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8765312814","display_name":null,"funder_award_id":"R0I CA58311","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G960587173","display_name":null,"funder_award_id":"R0I DE10845","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031900304.pdf","grobid_xml":"https://content.openalex.org/works/W2031900304.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W137936598","https://openalex.org/W1517150667","https://openalex.org/W1521352631","https://openalex.org/W1545152283","https://openalex.org/W1554133437","https://openalex.org/W1561043766","https://openalex.org/W1567487285","https://openalex.org/W1573411722","https://openalex.org/W1575281088","https://openalex.org/W1585336990","https://openalex.org/W1599282089","https://openalex.org/W1660300003","https://openalex.org/W1669342624","https://openalex.org/W1794257889","https://openalex.org/W1964201687","https://openalex.org/W1969191130","https://openalex.org/W1971915141","https://openalex.org/W1972153522","https://openalex.org/W1977302628","https://openalex.org/W1983475354","https://openalex.org/W1987339712","https://openalex.org/W1989170373","https://openalex.org/W1997399258","https://openalex.org/W1999157780","https://openalex.org/W2003411699","https://openalex.org/W2009426565","https://openalex.org/W2025993620","https://openalex.org/W2031160500","https://openalex.org/W2035936653","https://openalex.org/W2044420109","https://openalex.org/W2056274413","https://openalex.org/W2057126981","https://openalex.org/W2060138882","https://openalex.org/W2074254324","https://openalex.org/W2091857312","https://openalex.org/W2095365445","https://openalex.org/W2095498651","https://openalex.org/W2096910536","https://openalex.org/W2114918609","https://openalex.org/W2120023582","https://openalex.org/W2135092755","https://openalex.org/W2162333016","https://openalex.org/W2317224850","https://openalex.org/W2329029967","https://openalex.org/W2418318938","https://openalex.org/W2444477924"],"related_works":["https://openalex.org/W7098930580","https://openalex.org/W2075614933","https://openalex.org/W4200406295","https://openalex.org/W2463244004","https://openalex.org/W2279890068","https://openalex.org/W642298316","https://openalex.org/W2358284869","https://openalex.org/W2034880956","https://openalex.org/W2284299947","https://openalex.org/W2141606844"],"abstract_inverted_index":{"Increased":[0],"mortality":[1],"of":[2,14,19,34,55,60,68,86,90,152,213,256,268,290,307,315,334],"patients":[3,338],"with":[4,118,132,182,276,340],"oral":[5,80,215,272,341],"cancer":[6],"largely":[7],"reflects":[8],"the":[9,15,32,39,46,53,64,79,84,91,112,123,150,162,178,190,232,242,254,269,298,321,332,335],"local":[10],"and":[11,94,282],"regional":[12],"spread":[13,108,333],"disease.":[16],"The":[17,265],"invasiveness":[18,67,267,306],"these":[20],"tumours":[21,129,179,185],"requires":[22],"hydrolases":[23],"which":[24,159,177],"are":[25,42,98],"regulated":[26,43],"through":[27,45],"AP-1-dependent":[28],"transcriptional":[29],"mechanisms.":[30],"Since":[31],"amount/activity":[33],"transcription":[35],"factors":[36],"bound":[37],"to":[38,105,122,258,301],"AP-1":[40],"motif":[41],"partly":[44],"extracellular":[47],"signal-regulated":[48],"kinases":[49],"(ERK1/ERK2),":[50],"we":[51,252],"determined":[52],"effect":[54],"PD":[56,142,183,208,233,270,327],"098059,":[57,184],"an":[58,146,313],"inhibitor":[59,314],"ERK1/ERK2":[61,283,316],"activation,":[62],"on":[63,241],"in":[65,109,111,167,173,176,200,205,221,231,304,337],"vivo":[66,110,305],"a":[69,102,237,288,291,308],"human":[70],"squamous":[71,216],"cell":[72,74,217],"carcinoma":[73],"line":[75],"(UM-SCC-1)":[76],"derived":[77],"from":[78],"cavity.":[81],"We":[82],"utilized":[83],"floor":[85],"mouth":[87],"musculature":[88],"consisting":[89],"mylohyoid,":[92],"geniohyoid":[93,193],"genioglossus":[95,163],"muscle":[96,243],"(which":[97],"sequentially":[99],"arranged),":[100],"as":[101,247,249],"natural":[103],"barrier":[104],"assess":[106],"tumour":[107,119,293],"nude":[113],"mouse.":[114],"Mice":[115],"were":[116,130,165,180],"inoculated":[117],"cells":[120],"superficial":[121],"mylohyoid":[124,191],"muscle.":[125],"After":[126],"18":[127],"days,":[128,149],"injected":[131,181],"either":[133],"empty":[134],"liposomes":[135,138],"(control)":[136],"or":[137,192],"containing":[139],"5":[140],"microM":[141],"098059":[143,328],"and,":[144],"after":[145],"additional":[147],"22":[148],"jaws":[151],"mice":[153,175,203,224],"examined":[154],"histologically.":[155],"Highly":[156],"infiltrative":[157],"tumours,":[158],"had":[160],"penetrated":[161,196],"muscle,":[164],"evident":[166,220],"10/12":[168],"control":[169,202,223],"mice.":[170,210,235],"In":[171],"contrast,":[172],"9/12":[174],"did":[186],"not":[187,287],"extend":[188],"beyond":[189],"muscles.":[194],"Tumours":[195],"bone":[197,250],"nutrient":[198],"canals":[199],"7/12":[201],"but":[204,225,285],"only":[206],"3/12":[207],"098059-treated":[209,234],"Neurotropism,":[211],"characteristic":[212],"aggressive":[214],"carcinoma,":[218],"was":[219,226,274,286],"6/12":[222],"completely":[227],"abolished":[228],"(0/12":[229],"mice)":[230],"Using":[236],"staging":[238],"system":[239],"based":[240],"layer":[244],"involved,":[245],"neurotropism,":[246],"well":[248],"involvement,":[251],"found":[253],"inhibition":[255],"invasion":[257],"be":[259],"statistically":[260],"significant":[261],"(P":[262],"<":[263],"0.01).":[264],"reduced":[266,303],"098059-liposome-treated":[271],"cancers":[273],"associated":[275],"diminished":[277],"92-kDa":[278],"type":[279],"IV":[280],"collagenase":[281],"activities":[284],"consequence":[289],"slower":[292],"growth":[294],"rate.":[295],"This":[296],"is":[297],"first":[299],"study":[300],"demonstrate":[302],"malignancy":[309],"brought":[310],"about":[311],"by":[312],"activation.":[317],"These":[318],"results":[319],"raise":[320],"exciting":[322],"possibility":[323],"that":[324],"second":[325],"generation":[326],"congeners":[329],"may":[330],"reduce":[331],"disease":[336],"afflicted":[339],"cancers.":[342]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
