{"id":"https://openalex.org/W203187590","doi":null,"title":"Remittive therapy in rheumatoid arthritis: clinical uses and mechanisms of action.","display_name":"Remittive therapy in rheumatoid arthritis: clinical uses and mechanisms of action.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W203187590","mag":"203187590","pmid":"https://pubmed.ncbi.nlm.nih.gov/6382973"},"language":"en","primary_location":{"id":"pmid:6382973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6382973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agents and actions. Supplements","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P E Lipsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043874873"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4522,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58884636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":null,"first_page":"181","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gold-compounds","display_name":"gold compounds","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.8080000281333923},{"id":"https://openalex.org/keywords/penicillamine","display_name":"D-penicillamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8521846532821655},{"id":"https://openalex.org/C2780570811","wikidata":"https://www.wikidata.org/wiki/Q2736147","display_name":"Gold salts","level":3,"score":0.6448004245758057},{"id":"https://openalex.org/C2779348387","wikidata":"https://www.wikidata.org/wiki/Q421239","display_name":"Penicillamine","level":2,"score":0.6275901794433594},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5852974653244019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5194658637046814},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4972057640552521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4307248592376709},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40012794733047485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19204270839691162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18787461519241333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09553435444831848}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6382973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6382973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agents and actions. Supplements","raw_type":"Journal Article"},{"id":"mag:203187590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6382973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085867374","https://openalex.org/W195248455","https://openalex.org/W11458546","https://openalex.org/W1758604107","https://openalex.org/W1997839055","https://openalex.org/W2139511329","https://openalex.org/W2417488629","https://openalex.org/W16628677","https://openalex.org/W1039422329","https://openalex.org/W2410848044"],"abstract_inverted_index":{"Evidence":[0],"has":[1,27],"been":[2],"reviewed":[3],"supporting":[4],"the":[5,14,22,35,41,68,81,90,114,125,138,142],"conclusion":[6,123],"that":[7,25,89,124,141],"gold":[8],"compounds,":[9],"anti-malarials":[10,56],"and":[11,55],"D-penicillamine":[12,74],"have":[13,128],"capacity":[15,65],"to":[16,46,58,66,119],"function":[17,36,69],"as":[18,109],"immunosuppressive":[19,112],"drugs.":[20],"Moreover,":[21],"results":[23,87],"indicate":[24],"each":[26,104],"a":[28,78,110],"unique":[29],"site":[30],"of":[31,37,40,43,63,70,80,83,105,131,145,152],"action,":[32],"specifically":[33],"inhibiting":[34,77],"only":[38],"one":[39,148],"populations":[42],"cells":[44],"likely":[45],"be":[47,59,120],"involved":[48],"in":[49,133],"chronic":[50],"immunologically-mediated":[51],"inflammation.":[52],"Gold":[53],"compounds":[54,107],"appear":[57],"active":[60],"by":[61,76,92,137],"virtue":[62],"their":[64],"depress":[67],"mononuclear":[71],"phagocytes,":[72],"while":[73,103],"acts":[75,108],"number":[79],"activities":[82],"T":[84],"lymphocytes.":[85],"These":[86],"imply":[88],"means":[91],"which":[93],"these":[94,106],"drugs":[95,127],"suppress":[96],"rheumatoid":[97],"inflammation":[98],"are":[99],"fundamentally":[100],"different.":[101,121],"Thus,":[102],"selective":[111],"agent,":[113],"target":[115],"cell":[116],"inhibited":[117],"appears":[118],"The":[122],"remission-inducing":[126],"different":[129],"modes":[130],"action":[132],"RA":[134],"is":[135,149],"supported":[136],"clinical":[139],"observation":[140],"success":[143],"rate":[144],"therapy":[146,154],"with":[147,155],"comparable":[150],"regardless":[151],"antecedent":[153],"another":[156],"(125,":[157],"126).":[158]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}