{"id":"https://openalex.org/W2031741465","doi":"https://doi.org/10.1117/1.jbo.17.6.066006","title":"Ultrasound-modulated optical tomography at new depth","display_name":"Ultrasound-modulated optical tomography at new depth","publication_year":2012,"publication_date":"2012-06-04","ids":{"openalex":"https://openalex.org/W2031741465","doi":"https://doi.org/10.1117/1.jbo.17.6.066006","mag":"2031741465","pmid":"https://pubmed.ncbi.nlm.nih.gov/22734762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381033"},"language":"en","primary_location":{"id":"doi:10.1117/1.jbo.17.6.066006","doi":"https://doi.org/10.1117/1.jbo.17.6.066006","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.17.6.066006","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-6/066006/Ultrasound-modulated-optical-tomography-at-new-depth/10.1117/1.JBO.17.6.066006.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-6/066006/Ultrasound-modulated-optical-tomography-at-new-depth/10.1117/1.JBO.17.6.066006.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043243765","display_name":"Puxiang Lai","orcid":"https://orcid.org/0000-0003-4811-2012","observed_orcids":["https://orcid.org/0000-0003-4811-2012"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puxiang Lai","raw_affiliation_strings":["Washington Univ in St. Louis","Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130, USA"],"raw_orcid":"https://orcid.org/0000-0003-4811-2012","affiliations":[{"raw_affiliation_string":"Washington Univ in St. Louis","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082775720","display_name":"Xiao Xu","orcid":"https://orcid.org/0000-0002-3526-1724","observed_orcids":["https://orcid.org/0000-0002-3526-1724"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao Xu","raw_affiliation_strings":["Washington Univ. in St. Louis","Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Univ. in St. Louis","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008233636","display_name":"Lihong V. Wang","orcid":"https://orcid.org/0000-0001-9783-4383","observed_orcids":["https://orcid.org/0000-0001-9783-4383"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihong V. Wang","raw_affiliation_strings":["Washington Univ in St. Louis","Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130"],"raw_orcid":"https://orcid.org/0000-0001-9783-4383","affiliations":[{"raw_affiliation_string":"Washington Univ in St. Louis","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":1675,"currency":"USD","value_usd":1675},"apc_paid":null,"fwci":2.601,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88174642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"06","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.37720000743865967,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound-modulated-optical-tomography","display_name":"ultrasound-modulated optical tomography","score":0.9990000128746033},{"id":"https://openalex.org/keywords/two-beam-coupling","display_name":"two-wave mixing","score":0.8289999961853027},{"id":"https://openalex.org/keywords/optical-fiber-bundle","display_name":"optical fiber bundle","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tissue-phantoms","display_name":"tissue phantoms","score":0.9750000238418579},{"id":"https://openalex.org/keywords/deep-tissue-imaging","display_name":"deep tissue imaging","score":0.5799999833106995},{"id":"https://openalex.org/keywords/optical-contrast","display_name":"optical contrast","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.687239408493042},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.6818872690200806},{"id":"https://openalex.org/C63131636","wikidata":"https://www.wikidata.org/wiki/Q505293","display_name":"Photorefractive effect","level":2,"score":0.6302314400672913},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.6248910427093506},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6012282371520996},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.48213478922843933},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.4482665956020355},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.23983898758888245},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14607903361320496}],"mesh":[{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007368","descriptor_name":"Interferometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017785","descriptor_name":"Photons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1117/1.jbo.17.6.066006","doi":"https://doi.org/10.1117/1.jbo.17.6.066006","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.17.6.066006","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-6/066006/Ultrasound-modulated-optical-tomography-at-new-depth/10.1117/1.JBO.17.6.066006.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2668695","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3381033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381033","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Opt","raw_type":"Text"},{"id":"pmid:22734762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22734762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical optics","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:69685","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20160817-073054013","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1117/1.jbo.17.6.066006","doi":"https://doi.org/10.1117/1.jbo.17.6.066006","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.17.6.066006","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-6/066006/Ultrasound-modulated-optical-tomography-at-new-depth/10.1117/1.JBO.17.6.066006.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3538799493","display_name":"Confocal Photacoustic Microscopy: Technology Development","funder_award_id":"R01EB000712","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6941673650","display_name":"Photoacoustic / Optical / Ultrasonic Imaging of Sentinel Lymph Nodes and Metastas","funder_award_id":"U54CA136398","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031741465.pdf","grobid_xml":"https://content.openalex.org/works/W2031741465.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1508635016","https://openalex.org/W1922375175","https://openalex.org/W1963504169","https://openalex.org/W1966152886","https://openalex.org/W1968901301","https://openalex.org/W1972360829","https://openalex.org/W1975484388","https://openalex.org/W1975915764","https://openalex.org/W1986682629","https://openalex.org/W2009190330","https://openalex.org/W2009379592","https://openalex.org/W2016170197","https://openalex.org/W2019463947","https://openalex.org/W2019564055","https://openalex.org/W2033705563","https://openalex.org/W2033769922","https://openalex.org/W2037883718","https://openalex.org/W2046588758","https://openalex.org/W2049651413","https://openalex.org/W2050701770","https://openalex.org/W2061363544","https://openalex.org/W2061871860","https://openalex.org/W2074939412","https://openalex.org/W2077538187","https://openalex.org/W2082495127","https://openalex.org/W2112388420","https://openalex.org/W2133863204","https://openalex.org/W2142211077","https://openalex.org/W2142393916","https://openalex.org/W2144875185","https://openalex.org/W2164081309","https://openalex.org/W4234854890","https://openalex.org/W4255137887"],"related_works":["https://openalex.org/W2037514317","https://openalex.org/W2280671086","https://openalex.org/W2895001970","https://openalex.org/W2138136577","https://openalex.org/W2279779894","https://openalex.org/W2100528826","https://openalex.org/W1979942702","https://openalex.org/W4386427702","https://openalex.org/W2037883718","https://openalex.org/W1998571602"],"abstract_inverted_index":{"Ultrasound-modulated":[0],"optical":[1,9,23,67],"tomography":[2],"(UOT)":[3],"has":[4,44,96,112],"the":[5,74,84,94,98],"potential":[6],"to":[7,47,72,100],"reveal":[8],"contrast":[10],"deep":[11],"inside":[12],"soft":[13],"biological":[14],"tissues":[15],"at":[16],"an":[17,48],"ultrasonically":[18],"determined":[19],"spatial":[20],"resolution.":[21],"The":[22],"imaging":[24,50],"depth":[25],"reported":[26],"so":[27],"far":[28],"has,":[29],"however,":[30],"been":[31,114],"limited,":[32],"which":[33,111],"prevents":[34],"this":[35],"technique":[36],"from":[37],"broader":[38],"applications.":[39],"Our":[40],"latest":[41],"experimental":[42],"exploration":[43],"pushed":[45],"UOT":[46,57],"unprecedented":[49],"depth.":[51],"We":[52],"developed":[53],"and":[54,80,91],"optimized":[55],"a":[56,60,103],"system":[58,95],"employing":[59],"photorefractive":[61,81],"crystal-based":[62],"interferometer.":[63],"A":[64],"large":[65],"aperture":[66],"fiber":[68],"bundle":[69],"was":[70],"used":[71],"enhance":[73],"efficiencies":[75],"for":[76,87],"diffuse":[77],"light":[78],"collection":[79],"two-wave-mixing.":[82],"Within":[83],"safety":[85],"limits":[86],"both":[88],"laser":[89],"illumination":[90],"ultrasound":[92],"modulation,":[93],"attained":[97],"ability":[99],"image":[101],"through":[102],"tissue-mimicking":[104],"phantom":[105],"of":[106],"9.4":[107],"cm":[108],"in":[109],"thickness,":[110],"never":[113],"reached":[115],"previously":[116],"by":[117],"UOT.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}