{"id":"https://openalex.org/W2031733136","doi":"https://doi.org/10.1126/science.279.5356.1504","title":"Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA","display_name":"Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA","publication_year":1998,"publication_date":"1998-03-06","ids":{"openalex":"https://openalex.org/W2031733136","doi":"https://doi.org/10.1126/science.279.5356.1504","mag":"2031733136","pmid":"https://pubmed.ncbi.nlm.nih.gov/9488644"},"language":"en","primary_location":{"id":"doi:10.1126/science.279.5356.1504","doi":"https://doi.org/10.1126/science.279.5356.1504","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.279.5356.1504","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012990749","display_name":"Matthew R. Redinbo","orcid":"https://orcid.org/0000-0003-0814-5346","observed_orcids":["https://orcid.org/0000-0003-0814-5346"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew R. Redinbo","raw_affiliation_strings":["M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050073558","display_name":"Lance J. Stewart","orcid":"https://orcid.org/0000-0003-4264-5125","observed_orcids":["https://orcid.org/0000-0003-4264-5125"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lance Stewart","raw_affiliation_strings":["M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000472988","display_name":"Peter K\u00fchn","orcid":"https://orcid.org/0000-0003-2629-4505","observed_orcids":["https://orcid.org/0000-0003-2629-4505"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kuhn","raw_affiliation_strings":["M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032960501","display_name":"James J. Champoux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Champoux","raw_affiliation_strings":["M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108085252","display_name":"Wim G. J. Hol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wim G. J. Hol","raw_affiliation_strings":["M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012990749","https://openalex.org/A5050073558","https://openalex.org/A5108085252"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210120900","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":17.6649,"has_fulltext":false,"cited_by_count":892,"citation_normalized_percentile":{"value":0.99676403,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"279","issue":"5356","first_page":"1504","last_page":"1513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":0.9269999861717224},{"id":"https://openalex.org/keywords/human-topoisomerase-i","display_name":"human topoisomerase I","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dna-topoisomerase","display_name":"DNA topoisomerase","score":0.6029999852180481},{"id":"https://openalex.org/keywords/dna-duplex-binding","display_name":"DNA duplex binding","score":0.38499999046325684},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8140000104904175},{"id":"https://openalex.org/keywords/active-site-nucleophile","display_name":"active site nucleophile","score":0.75},{"id":"https://openalex.org/keywords/anticancer-drug-binding","display_name":"anticancer drug binding","score":0.7559999823570251},{"id":"https://openalex.org/keywords/b-dna","display_name":"B-DNA","score":0.7710000276565552},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.8413724303245544},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7008270025253296},{"id":"https://openalex.org/C158456008","wikidata":"https://www.wikidata.org/wiki/Q412639","display_name":"DNA supercoil","level":4,"score":0.6113556623458862},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5301165580749512},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5215211510658264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5175485014915466},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4839959144592285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3813943862915039},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.3795512914657593},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3565768599510193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3329319953918457},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050811","descriptor_name":"Octamer Transcription Factor-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051863","descriptor_name":"Host Cell Factor C1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.279.5356.1504","doi":"https://doi.org/10.1126/science.279.5356.1504","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.279.5356.1504","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9488644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9488644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2453331063","display_name":null,"funder_award_id":"GM49156","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5610247372","display_name":null,"funder_award_id":"CA 65656","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5812598334","display_name":"Eukaryotic Topoisomerase I","funder_award_id":"R01GM049156","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6162113785","display_name":"STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS","funder_award_id":"R01CA065656","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W176011971","https://openalex.org/W192877506","https://openalex.org/W656827624","https://openalex.org/W1482083885","https://openalex.org/W1499356698","https://openalex.org/W1536538430","https://openalex.org/W1549846058","https://openalex.org/W1567210923","https://openalex.org/W1571918776","https://openalex.org/W1591680814","https://openalex.org/W1608352093","https://openalex.org/W1923310201","https://openalex.org/W1981987977","https://openalex.org/W1984243651","https://openalex.org/W1993390869","https://openalex.org/W1993404146","https://openalex.org/W1996083335","https://openalex.org/W1996607909","https://openalex.org/W1997361520","https://openalex.org/W1999506028","https://openalex.org/W1999902563","https://openalex.org/W2004689349","https://openalex.org/W2005831319","https://openalex.org/W2006758809","https://openalex.org/W2014548472","https://openalex.org/W2018185888","https://openalex.org/W2019635509","https://openalex.org/W2022493864","https://openalex.org/W2028231353","https://openalex.org/W2028933585","https://openalex.org/W2030893594","https://openalex.org/W2032894521","https://openalex.org/W2034699412","https://openalex.org/W2040000960","https://openalex.org/W2044082153","https://openalex.org/W2044615643","https://openalex.org/W2067332276","https://openalex.org/W2071032119","https://openalex.org/W2072546473","https://openalex.org/W2074601949","https://openalex.org/W2078751203","https://openalex.org/W2080476827","https://openalex.org/W2087036937","https://openalex.org/W2089219339","https://openalex.org/W2090247166","https://openalex.org/W2091969321","https://openalex.org/W2092975253","https://openalex.org/W2100113089","https://openalex.org/W2106315897","https://openalex.org/W2136007486","https://openalex.org/W2137345862","https://openalex.org/W2154238937","https://openalex.org/W2162929639","https://openalex.org/W2218064154","https://openalex.org/W2313508933","https://openalex.org/W2409350485","https://openalex.org/W4236530034","https://openalex.org/W6600025664","https://openalex.org/W6600335371","https://openalex.org/W6602474116","https://openalex.org/W6602578867"],"related_works":["https://openalex.org/W2062634597","https://openalex.org/W2729982354","https://openalex.org/W2162929639","https://openalex.org/W2006424757","https://openalex.org/W2074902034","https://openalex.org/W2006853138","https://openalex.org/W22022962","https://openalex.org/W1871475547","https://openalex.org/W2067332276","https://openalex.org/W7100526025"],"abstract_inverted_index":{"Topoisomerases":[0],"I":[1,42],"promote":[2],"the":[3,22,44,72,77,81,84,93,103,110],"relaxation":[4],"of":[5,24,38,76,80,96,112,122],"DNA":[6,17,57,97],"superhelical":[7],"tension":[8],"by":[9],"introducing":[10],"a":[11],"transient":[12],"single-stranded":[13],"break":[14],"in":[15,49],"duplex":[16],"and":[18,27,34,46,51,71,114],"are":[19],"vital":[20],"for":[21,102],"processes":[23],"replication,":[25],"transcription,":[26],"recombination.":[28],"The":[29,68],"crystal":[30],"structures":[31,121],"at":[32],"2.1":[33],"2.5":[35],"angstrom":[36],"resolution":[37],"reconstituted":[39],"human":[40],"topoisomerase":[41,123],"comprising":[43],"core":[45,69],"carboxyl-terminal":[47,78],"domains":[48],"covalent":[50],"noncovalent":[52],"complexes":[53],"with":[54,92,118],"22-base":[55],"pair":[56],"duplexes":[58],"reveal":[59],"an":[60],"enzyme":[61],"that":[62],"\"clamps\"":[63],"around":[64],"essentially":[65],"B-form":[66],"DNA.":[67],"domain":[70,79],"first":[73],"eight":[74],"residues":[75],"enzyme,":[82],"including":[83],"active-site":[85],"nucleophile":[86],"tyrosine-723,":[87],"share":[88],"significant":[89],"structural":[90],"similarity":[91],"bacteriophage":[94],"family":[95],"integrases.":[98],"A":[99],"binding":[100],"mode":[101],"anticancer":[104],"drug":[105],"camptothecin":[106],"is":[107],"proposed":[108],"on":[109],"basis":[111],"chemical":[113],"biochemical":[115],"information":[116],"combined":[117],"these":[119],"three-dimensional":[120],"I-DNA":[124],"complexes.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":33},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
