{"id":"https://openalex.org/W2031708834","doi":"https://doi.org/10.1007/s00253-014-5895-0","title":"Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production","display_name":"Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production","publication_year":2014,"publication_date":"2014-07-03","ids":{"openalex":"https://openalex.org/W2031708834","doi":"https://doi.org/10.1007/s00253-014-5895-0","mag":"2031708834","pmid":"https://pubmed.ncbi.nlm.nih.gov/24997118"},"language":"en","primary_location":{"id":"doi:10.1007/s00253-014-5895-0","doi":"https://doi.org/10.1007/s00253-014-5895-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00253-014-5895-0","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028913983","display_name":"John Blazeck","orcid":"https://orcid.org/0000-0002-6110-2938","observed_orcids":["https://orcid.org/0000-0002-6110-2938"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Blazeck","raw_affiliation_strings":["McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091313349","display_name":"Jarrett Miller","orcid":"https://orcid.org/0000-0003-4408-3461","observed_orcids":["https://orcid.org/0000-0003-4408-3461"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarrett Miller","raw_affiliation_strings":["McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077023989","display_name":"Anny Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anny Pan","raw_affiliation_strings":["McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073998733","display_name":"Jon Gengler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Gengler","raw_affiliation_strings":["Department of Chemistry & Biochemistry, The University of Texas at Austin, 105 E 24th St. Stop A5300, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Austin, 105 E 24th St. Stop A5300, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036804018","display_name":"Clinton Holden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clinton Holden","raw_affiliation_strings":["McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074527137","display_name":"Mariam Jamoussi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariam Jamoussi","raw_affiliation_strings":["McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023917549","display_name":"Hal S. Alper","orcid":"https://orcid.org/0000-0002-8246-8605","observed_orcids":["https://orcid.org/0000-0002-8246-8605"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hal S. Alper","raw_affiliation_strings":["Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway Avenue, Austin, TX, 78712, USA","McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway Avenue, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023917549"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":4.0983,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.95201423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"98","issue":"19","first_page":"8155","last_page":"8164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14150","display_name":"Biochemical and biochemical processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itaconic-acid-production","display_name":"itaconic acid production","score":0.9900000095367432},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hybrid-promoter","display_name":"hybrid promoter","score":0.6679999828338623},{"id":"https://openalex.org/keywords/genome-scale-metabolic-modeling","display_name":"genome-scale metabolic modeling","score":0.5659999847412109},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.3709999918937683},{"id":"https://openalex.org/keywords/enzyme-localization","display_name":"enzyme localization","score":0.421999990940094},{"id":"https://openalex.org/keywords/mitochondrial-targeting","display_name":"mitochondrial targeting","score":0.6299999952316284},{"id":"https://openalex.org/keywords/bio-based-chemicals","display_name":"bio-based chemicals","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2779990784","wikidata":"https://www.wikidata.org/wiki/Q903311","display_name":"Itaconic acid","level":4,"score":0.9907981753349304},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.716166079044342},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.6365536451339722},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5424715876579285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4927656948566437},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.48441699147224426},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.4627290964126587},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4482387602329254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4185650944709778},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3534996807575226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3502282202243805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28989601135253906},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0854647159576416},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06754466891288757},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00253-014-5895-0","doi":"https://doi.org/10.1007/s00253-014-5895-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00253-014-5895-0","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:24997118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24997118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied microbiology and biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1499249769","https://openalex.org/W1546379415","https://openalex.org/W1550965069","https://openalex.org/W1560259396","https://openalex.org/W1850569493","https://openalex.org/W1971600316","https://openalex.org/W1978119727","https://openalex.org/W1989488173","https://openalex.org/W1990060260","https://openalex.org/W1993275546","https://openalex.org/W1996629685","https://openalex.org/W1997347763","https://openalex.org/W1998485639","https://openalex.org/W2000206290","https://openalex.org/W2044318175","https://openalex.org/W2047632644","https://openalex.org/W2048449135","https://openalex.org/W2056305771","https://openalex.org/W2056924389","https://openalex.org/W2063464385","https://openalex.org/W2086998769","https://openalex.org/W2090013326","https://openalex.org/W2092087282","https://openalex.org/W2097468432","https://openalex.org/W2097666362","https://openalex.org/W2102221598","https://openalex.org/W2102957972","https://openalex.org/W2116267252","https://openalex.org/W2122655459","https://openalex.org/W2127412690","https://openalex.org/W2137424160","https://openalex.org/W2140948740","https://openalex.org/W2142798851","https://openalex.org/W2144634347","https://openalex.org/W2147472054","https://openalex.org/W2154797402","https://openalex.org/W2164098890","https://openalex.org/W2165268542","https://openalex.org/W2169769082","https://openalex.org/W2170298003","https://openalex.org/W2274699581","https://openalex.org/W2804007336"],"related_works":["https://openalex.org/W4407705793","https://openalex.org/W4416424810","https://openalex.org/W4296202160","https://openalex.org/W4401452016","https://openalex.org/W1732590418","https://openalex.org/W4387117622","https://openalex.org/W4411456576","https://openalex.org/W3186908979","https://openalex.org/W2572600078","https://openalex.org/W4313339542"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}