{"id":"https://openalex.org/W2031675835","doi":"https://doi.org/10.1074/jbc.c110.216580","title":"Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Regulates Autophagy in Cultured Astrocytes","display_name":"Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Regulates Autophagy in Cultured Astrocytes","publication_year":2011,"publication_date":"2011-05-25","ids":{"openalex":"https://openalex.org/W2031675835","doi":"https://doi.org/10.1074/jbc.c110.216580","mag":"2031675835","pmid":"https://pubmed.ncbi.nlm.nih.gov/21610076","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3151033"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.c110.216580","doi":"https://doi.org/10.1074/jbc.c110.216580","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c110.216580","pdf_url":"http://www.jbc.org/article/S0021925820575054/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820575054/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001000307","display_name":"Gustavo J.S. Pereira","orcid":"https://orcid.org/0000-0002-6765-1276","observed_orcids":["https://orcid.org/0000-0002-6765-1276"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo J.S. Pereira","raw_affiliation_strings":["From the Department of Pharmacology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 04044-020, Brazil","Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 04044-020, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109168612","display_name":"Hanako Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hanako Hirata","raw_affiliation_strings":["Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055234275","display_name":"Gian Mar\u00eda Fimia","orcid":"https://orcid.org/0000-0003-4438-3325","observed_orcids":["https://orcid.org/0000-0003-4438-3325"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian M. Fimia","raw_affiliation_strings":["Department of Biology, University of Rome \u2018Tor Vergata\u2019, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome \u2018Tor Vergata\u2019, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019767513","display_name":"L\u00facia Garcez do Carmo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L\u00facia G. do Carmo","raw_affiliation_strings":["Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054119713","display_name":"Cl\u00e1udia Bincoletto","orcid":"https://orcid.org/0000-0001-6666-3673","observed_orcids":["https://orcid.org/0000-0001-6666-3673"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Claudia Bincoletto","raw_affiliation_strings":["Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087103284","display_name":"Sang Won Han","orcid":"https://orcid.org/0000-0002-4953-7680","observed_orcids":["https://orcid.org/0000-0002-4953-7680"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sang W. Han","raw_affiliation_strings":["Interdisciplinary Center for Gene Therapy, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 09210-170, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Center for Gene Therapy, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 09210-170, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067677134","display_name":"Roberta Sessa Stilhano","orcid":"https://orcid.org/0000-0002-0653-5968","observed_orcids":["https://orcid.org/0000-0002-0653-5968"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberta S. Stilhano","raw_affiliation_strings":["Interdisciplinary Center for Gene Therapy, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 09210-170, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Center for Gene Therapy, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 09210-170, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036125335","display_name":"Rodrigo Portes Ureshino","orcid":"https://orcid.org/0000-0003-3371-3376","observed_orcids":["https://orcid.org/0000-0003-3371-3376"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo P. Ureshino","raw_affiliation_strings":["Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039630516","display_name":"Duncan Bloor-Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Duncan Bloor-Young","raw_affiliation_strings":["Department of Pharmacology, University of Oxford, Oxford OX1 2JD, United Kingdom, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Oxford, Oxford OX1 2JD, United Kingdom, and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013996756","display_name":"Grant C. Churchill","orcid":"https://orcid.org/0000-0001-9591-9391","observed_orcids":["https://orcid.org/0000-0001-9591-9391"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant Churchill","raw_affiliation_strings":["Department of Pharmacology, University of Oxford, Oxford OX1 2JD, United Kingdom, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Oxford, Oxford OX1 2JD, United Kingdom, and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050710377","display_name":"Mauro Piacentini","orcid":"https://orcid.org/0000-0003-2919-1296","observed_orcids":["https://orcid.org/0000-0003-2919-1296"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mauro Piacentini","raw_affiliation_strings":["Interdisciplinary Center for Gene Therapy, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 09210-170, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Center for Gene Therapy, Federal University of S\u00e3o Paulo, S\u00e3o Paulo SP 09210-170, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086481218","display_name":"Sandip Patel","orcid":"https://orcid.org/0000-0001-7247-2013","observed_orcids":["https://orcid.org/0000-0001-7247-2013"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sandip Patel","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London WC1E 6, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London WC1E 6, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056013254","display_name":"Soraya Soubhi Smaili","orcid":"https://orcid.org/0000-0001-5844-1368","observed_orcids":["https://orcid.org/0000-0001-5844-1368"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Soraya S. Smaili","raw_affiliation_strings":["Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo SP 04044-020, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056013254"],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.3382,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.9791453,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"286","issue":"32","first_page":"27875","last_page":"27881"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.9129999876022339},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/two-pore-channels","display_name":"two-pore channels","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tpc2","display_name":"TPC2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.6859999895095825},{"id":"https://openalex.org/keywords/acidic-organelles","display_name":"acidic organelles","score":0.8190000057220459},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.9750000238418579},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7036278247833252},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.700808048248291},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6409657597541809},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6197553873062134},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5709664225578308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.507899820804596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4681684672832489},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.4636557996273041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4590635895729065},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071186","descriptor_name":"Beclin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1074/jbc.c110.216580","doi":"https://doi.org/10.1074/jbc.c110.216580","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c110.216580","pdf_url":"http://www.jbc.org/article/S0021925820575054/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2420827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3151033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3151033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3151033","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21610076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21610076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3191819","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3191819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:art.torvergata.it:2108/19397","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/19397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1318847","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1318847/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J BIOL CHEM , 286 (32) 27875 - 27881. (2011)","raw_type":"Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1319217","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1319217","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1319315","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1319315","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisalento.it:11587/395267","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11587/395267","pdf_url":null,"source":{"id":"https://openalex.org/S7407055257","display_name":"AIRUS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/33953","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/33953","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.c110.216580","doi":"https://doi.org/10.1074/jbc.c110.216580","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c110.216580","pdf_url":"http://www.jbc.org/article/S0021925820575054/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2741465026","display_name":"The molecular basis for calcium release by NAADP","funder_award_id":"BB/G013721/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8037848246","display_name":null,"funder_award_id":"BB/G013721/1","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031675835.pdf","grobid_xml":"https://content.openalex.org/works/W2031675835.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1526993239","https://openalex.org/W1599277155","https://openalex.org/W1953311373","https://openalex.org/W1964384026","https://openalex.org/W1964549513","https://openalex.org/W1968004900","https://openalex.org/W1968111997","https://openalex.org/W1968966344","https://openalex.org/W1977767269","https://openalex.org/W1988252217","https://openalex.org/W1989051519","https://openalex.org/W1991075835","https://openalex.org/W1995138459","https://openalex.org/W2003787957","https://openalex.org/W2005727437","https://openalex.org/W2007066406","https://openalex.org/W2011432266","https://openalex.org/W2015426350","https://openalex.org/W2029205502","https://openalex.org/W2031790758","https://openalex.org/W2037388166","https://openalex.org/W2056663185","https://openalex.org/W2065368005","https://openalex.org/W2068412376","https://openalex.org/W2073308483","https://openalex.org/W2077731318","https://openalex.org/W2081583827","https://openalex.org/W2082796078","https://openalex.org/W2086510909","https://openalex.org/W2088093088","https://openalex.org/W2090896684","https://openalex.org/W2112045725","https://openalex.org/W2120788536","https://openalex.org/W2123755851","https://openalex.org/W2128537698","https://openalex.org/W2133772521","https://openalex.org/W2146447679","https://openalex.org/W2161432643","https://openalex.org/W2743254891"],"related_works":["https://openalex.org/W7120638962","https://openalex.org/W2137685799","https://openalex.org/W2018745495","https://openalex.org/W3167516263","https://openalex.org/W3172322582","https://openalex.org/W2068412376","https://openalex.org/W2141913307","https://openalex.org/W1494218055","https://openalex.org/W7037758422","https://openalex.org/W4416446076"],"abstract_inverted_index":{"Nicotinic":[0],"acid":[1],"adenine":[2],"dinucleotide":[3],"phosphate":[4],"(NAADP)":[5],"is":[6,29,44],"a":[7,40,111],"potent":[8],"Ca(2+)-mobilizing":[9],"messenger":[10,41],"that":[11,25,58,73,85,119],"in":[12,42,69,103,108],"many":[13],"cells":[14,109],"releases":[15],"Ca(2+)":[16,27,64,121],"from":[17,66],"the":[18,32,95],"endolysosomal":[19],"system.":[20],"Recent":[21],"studies":[22],"have":[23,50],"shown":[24],"NAADP-induced":[26],"mobilization":[28],"mediated":[30,123],"by":[31,124],"two-pore":[33],"channels":[34],"(TPCs).":[35],"Whether":[36],"NAADP":[37,62,86],"acts":[38],"as":[39],"astrocytes":[43,71],"unclear,":[45],"and":[46,72,92,99],"downstream":[47],"functional":[48],"consequences":[49],"yet":[51],"to":[52],"be":[53],"defined.":[54],"Here,":[55],"we":[56],"show":[57,84],"intracellular":[59],"delivery":[60],"of":[61,80,94],"evokes":[63],"signals":[65,75,122],"acidic":[67,88],"organelles":[68],"rat":[70],"these":[74],"are":[76],"potentiated":[77],"upon":[78],"overexpression":[79],"TPCs.":[81],"We":[82],"also":[83],"increases":[87,102],"vesicular":[89],"organelle":[90],"formation":[91],"levels":[93,105],"autophagic":[96],"markers,":[97],"LC3II":[98,104],"beclin-1.":[100],"NAADP-mediated":[101],"were":[106],"reduced":[107],"expressing":[110],"dominant-negative":[112],"TPC2":[113],"construct.":[114],"Our":[115],"data":[116],"provide":[117],"evidence":[118],"NAADP-evoked":[120],"TPCs":[125],"regulate":[126],"autophagy.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
