{"id":"https://openalex.org/W2031661929","doi":"https://doi.org/10.1016/0378-1119(94)90633-5","title":"The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth","display_name":"The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W2031661929","doi":"https://doi.org/10.1016/0378-1119(94)90633-5","mag":"2031661929","pmid":"https://pubmed.ncbi.nlm.nih.gov/7530227"},"language":"en","primary_location":{"id":"doi:10.1016/0378-1119(94)90633-5","doi":"https://doi.org/10.1016/0378-1119(94)90633-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-1119(94)90633-5","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109857380","display_name":"Wai-Kwong Eng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wai-Kwong Eng","raw_affiliation_strings":["Department of Biomolecular Disovery, SmithKline Beecham Pharmaceuticals King of Prussia, PA 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Disovery, SmithKline Beecham Pharmaceuticals King of Prussia, PA 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036331253","display_name":"Leo F. Faucette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo Faucette","raw_affiliation_strings":["Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106082553","display_name":"Megan M. McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan M. McLaughlin","raw_affiliation_strings":["Departments of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063469423","display_name":"Robert Cafferkey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Cafferkey","raw_affiliation_strings":["Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054033391","display_name":"Yigal Koltin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yigal Koltin","raw_affiliation_strings":["Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077762210","display_name":"Rene A. Morris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rene A. Morris","raw_affiliation_strings":["Departments of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076433485","display_name":"Peter R. Young","orcid":"https://orcid.org/0000-0001-9034-2925","observed_orcids":["https://orcid.org/0000-0001-9034-2925","https://orcid.org/0000-0002-5666-6499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter R. Young","raw_affiliation_strings":["Departments of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103465098","display_name":"Randall K. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Randall K. Johnson","raw_affiliation_strings":["Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111858645","display_name":"George P. Livi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George P. Livi","raw_affiliation_strings":["Departments of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103465098"],"corresponding_institution_ids":[],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":2.4424,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.89984095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"151","issue":"1-2","first_page":"61","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.47780001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.47780001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.47290000319480896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.925000011920929},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/fkbp12","display_name":"FKBP12","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cyclophilin","display_name":"cyclophilin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.6499999761581421},{"id":"https://openalex.org/keywords/transmembrane-proteins","display_name":"transmembrane proteins","score":0.7149999737739563},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.3919999897480011},{"id":"https://openalex.org/keywords/interleukin-2-transcription","display_name":"interleukin-2 transcription","score":0.7730000019073486},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8199999928474426},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8629999756813049},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8357950448989868},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.8038979768753052},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.6400298476219177},{"id":"https://openalex.org/C2776326521","wikidata":"https://www.wikidata.org/wiki/Q3774751","display_name":"Cyclophilin","level":3,"score":0.5636404752731323},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5545884966850281},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5204342007637024},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5175753831863403},{"id":"https://openalex.org/C133956753","wikidata":"https://www.wikidata.org/wiki/Q583864","display_name":"FKBP","level":2,"score":0.5091158747673035},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4839187264442444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39205268025398254},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35657116770744324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3409888446331024},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10116252303123474},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054714","descriptor_name":"Echinocandins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0378-1119(94)90633-5","doi":"https://doi.org/10.1016/0378-1119(94)90633-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-1119(94)90633-5","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"pmid:7530227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W16789104","https://openalex.org/W19446119","https://openalex.org/W645049130","https://openalex.org/W1517480469","https://openalex.org/W1523162832","https://openalex.org/W1525971266","https://openalex.org/W1547269929","https://openalex.org/W1566331922","https://openalex.org/W1801751795","https://openalex.org/W1841455434","https://openalex.org/W1863217888","https://openalex.org/W1883914716","https://openalex.org/W1886453687","https://openalex.org/W1888736125","https://openalex.org/W1969971113","https://openalex.org/W1970842110","https://openalex.org/W1975304761","https://openalex.org/W1982869248","https://openalex.org/W1984754431","https://openalex.org/W1985339191","https://openalex.org/W1985898403","https://openalex.org/W1997790615","https://openalex.org/W2002485919","https://openalex.org/W2003676968","https://openalex.org/W2015292449","https://openalex.org/W2024431372","https://openalex.org/W2024839583","https://openalex.org/W2025100148","https://openalex.org/W2034923228","https://openalex.org/W2039766781","https://openalex.org/W2039790756","https://openalex.org/W2041512157","https://openalex.org/W2055043387","https://openalex.org/W2057106513","https://openalex.org/W2058974266","https://openalex.org/W2063013559","https://openalex.org/W2068233575","https://openalex.org/W2075331771","https://openalex.org/W2087136249","https://openalex.org/W2089274824","https://openalex.org/W2089389853","https://openalex.org/W2090308278","https://openalex.org/W2095215072","https://openalex.org/W2099896929","https://openalex.org/W2114859236","https://openalex.org/W2115073295","https://openalex.org/W2123264979","https://openalex.org/W2123738381","https://openalex.org/W2129173045","https://openalex.org/W2138270253","https://openalex.org/W2142728054","https://openalex.org/W2148522035","https://openalex.org/W2165393736","https://openalex.org/W2187190111","https://openalex.org/W6646560544","https://openalex.org/W6656375277"],"related_works":["https://openalex.org/W2089274824","https://openalex.org/W1967407965","https://openalex.org/W1982869248","https://openalex.org/W1739306715","https://openalex.org/W2024431372","https://openalex.org/W1801751795","https://openalex.org/W1997790615","https://openalex.org/W2125672511","https://openalex.org/W2154035538","https://openalex.org/W1991119233"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}