{"id":"https://openalex.org/W2031640692","doi":"https://doi.org/10.1007/s12247-011-9109-3","title":"Model-Guided Design Space Development for a Drug Substance Manufacturing Process","display_name":"Model-Guided Design Space Development for a Drug Substance Manufacturing Process","publication_year":2011,"publication_date":"2011-07-25","ids":{"openalex":"https://openalex.org/W2031640692","doi":"https://doi.org/10.1007/s12247-011-9109-3","mag":"2031640692"},"language":"en","primary_location":{"id":"doi:10.1007/s12247-011-9109-3","doi":"https://doi.org/10.1007/s12247-011-9109-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12247-011-9109-3","pdf_url":null,"source":{"id":"https://openalex.org/S168111969","display_name":"Journal of Pharmaceutical Innovation","issn_l":"1872-5120","issn":["1872-5120","1939-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Innovation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086928022","display_name":"Justin L. Burt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Justin L. Burt","raw_affiliation_strings":["Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061042291","display_name":"Alan D. Braem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan D. Braem","raw_affiliation_strings":["Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078641292","display_name":"Antonio Ram\u0131\u0301rez","orcid":"https://orcid.org/0000-0003-2636-6855","observed_orcids":["https://orcid.org/0000-0003-2636-6855"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Ramirez","raw_affiliation_strings":["Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037703502","display_name":"Boguslaw Mudryk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boguslaw Mudryk","raw_affiliation_strings":["Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005131820","display_name":"Lucius T. Rossano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucius Rossano","raw_affiliation_strings":["Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110072748","display_name":"Srinivas Tummala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Tummala","raw_affiliation_strings":["Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Process Research and Development, Bristol-Myers Squibb Company, New Brunswick, USA","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086928022"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":2.913,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90376376,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"6","issue":"3","first_page":"181","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13180","display_name":"Chemistry and Chemical Engineering","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.875},{"id":"https://openalex.org/keywords/design-space","display_name":"design space","score":0.8700000047683716},{"id":"https://openalex.org/keywords/drug-substance-manufacturing","display_name":"drug substance manufacturing","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.8354969024658203},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.5842874050140381},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.568458616733551},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4765898883342743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4540756940841675},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.45089012384414673},{"id":"https://openalex.org/C55396564","wikidata":"https://www.wikidata.org/wiki/Q3084971","display_name":"Process design","level":3,"score":0.43551746010780334},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.4324685335159302},{"id":"https://openalex.org/C2777348039","wikidata":"https://www.wikidata.org/wiki/Q6423397","display_name":"Knowledge space","level":2,"score":0.41905465722084045},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.35199597477912903},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.3474871516227722},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.34265124797821045},{"id":"https://openalex.org/C174998907","wikidata":"https://www.wikidata.org/wiki/Q357662","display_name":"Work in process","level":2,"score":0.21733102202415466},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1416105329990387},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.13731461763381958},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12247-011-9109-3","doi":"https://doi.org/10.1007/s12247-011-9109-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12247-011-9109-3","pdf_url":null,"source":{"id":"https://openalex.org/S168111969","display_name":"Journal of Pharmaceutical Innovation","issn_l":"1872-5120","issn":["1872-5120","1939-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Innovation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W20497564","https://openalex.org/W1967804496","https://openalex.org/W1970399993","https://openalex.org/W1991001564","https://openalex.org/W1991618236","https://openalex.org/W1995049946","https://openalex.org/W2003091501","https://openalex.org/W2043938459","https://openalex.org/W2155378309","https://openalex.org/W2324308960"],"related_works":["https://openalex.org/W1995049946","https://openalex.org/W7042442603","https://openalex.org/W3003125810","https://openalex.org/W2042678275","https://openalex.org/W2972425091","https://openalex.org/W2913492173","https://openalex.org/W7220478591","https://openalex.org/W4393231655","https://openalex.org/W4411815078","https://openalex.org/W2441475052"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
