{"id":"https://openalex.org/W2031605083","doi":"https://doi.org/10.1016/j.ejphar.2011.09.003","title":"Umbelliferone modulates gamma-radiation induced reactive oxygen species generation and subsequent oxidative damage in human blood lymphocytes","display_name":"Umbelliferone modulates gamma-radiation induced reactive oxygen species generation and subsequent oxidative damage in human blood lymphocytes","publication_year":2011,"publication_date":"2011-09-22","ids":{"openalex":"https://openalex.org/W2031605083","doi":"https://doi.org/10.1016/j.ejphar.2011.09.003","mag":"2031605083","pmid":"https://pubmed.ncbi.nlm.nih.gov/21946110"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2011.09.003","doi":"https://doi.org/10.1016/j.ejphar.2011.09.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2011.09.003","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2031605083"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058758749","display_name":"Govindasamy Kanimozhi","orcid":"https://orcid.org/0000-0003-2873-9758","observed_orcids":["https://orcid.org/0000-0003-2873-9758"]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Govindasamy Kanimozhi","raw_affiliation_strings":["Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007462045","display_name":"Nagarajan Rajendra Prasad","orcid":"https://orcid.org/0000-0002-3937-8735","observed_orcids":["https://orcid.org/0000-0002-3937-8735"]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nagarajan Rajendra Prasad","raw_affiliation_strings":["Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033056479","display_name":"Ramachandran Samivel","orcid":"https://orcid.org/0000-0001-8301-8625","observed_orcids":["https://orcid.org/0000-0001-8301-8625"]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samivel Ramachandran","raw_affiliation_strings":["Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109932149","display_name":"Kodukkur Viswanathan Pugalendi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kodukkur Viswanathan Pugalendi","raw_affiliation_strings":["Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry of Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109932149"],"corresponding_institution_ids":["https://openalex.org/I197081775"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":2.9608,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.89439897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"672","issue":"1-3","first_page":"20","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11973","display_name":"Plant chemical constituents analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbelliferone","display_name":"umbelliferone","score":1.0},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/gamma-radiation","display_name":"gamma radiation","score":0.902999997138977},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9599999785423279},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.7649999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2779020807","wikidata":"https://www.wikidata.org/wiki/Q416196","display_name":"Umbelliferone","level":3,"score":0.9096482992172241},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7238519787788391},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6935461163520813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6559300422668457},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5626323223114014},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.5533737540245056},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5250028371810913},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5063027143478394},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.44738131761550903},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.4361543357372284},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43302851915359497},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38442954421043396},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3440912365913391},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.34206485748291016},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22539114952087402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1949249804019928},{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.08624845743179321},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014468","descriptor_name":"Umbelliferones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2011.09.003","doi":"https://doi.org/10.1016/j.ejphar.2011.09.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2011.09.003","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:21946110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21946110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1548420589","https://openalex.org/W1953660807","https://openalex.org/W1973101427","https://openalex.org/W1974945118","https://openalex.org/W1977964424","https://openalex.org/W1980090048","https://openalex.org/W1982459634","https://openalex.org/W1984416488","https://openalex.org/W1989156168","https://openalex.org/W1991775006","https://openalex.org/W1993068141","https://openalex.org/W1995382021","https://openalex.org/W2004534489","https://openalex.org/W2006370393","https://openalex.org/W2010339535","https://openalex.org/W2011469832","https://openalex.org/W2014895648","https://openalex.org/W2024716555","https://openalex.org/W2027511602","https://openalex.org/W2032710545","https://openalex.org/W2032924042","https://openalex.org/W2036268866","https://openalex.org/W2039232342","https://openalex.org/W2040530197","https://openalex.org/W2040706178","https://openalex.org/W2041613191","https://openalex.org/W2049457931","https://openalex.org/W2051342685","https://openalex.org/W2056758965","https://openalex.org/W2057638850","https://openalex.org/W2059406458","https://openalex.org/W2060194897","https://openalex.org/W2061333433","https://openalex.org/W2065853716","https://openalex.org/W2069975987","https://openalex.org/W2073674161","https://openalex.org/W2092629964","https://openalex.org/W2096795975","https://openalex.org/W2101861123","https://openalex.org/W2102742829","https://openalex.org/W2102836067","https://openalex.org/W2108159536","https://openalex.org/W2114379430","https://openalex.org/W2114918609","https://openalex.org/W2126614953","https://openalex.org/W2127390834","https://openalex.org/W2146651397","https://openalex.org/W2147564573","https://openalex.org/W2155784435","https://openalex.org/W2262595848","https://openalex.org/W2337672099","https://openalex.org/W2341211312","https://openalex.org/W2412132227","https://openalex.org/W2468119228","https://openalex.org/W2742512161"],"related_works":["https://openalex.org/W2187189274","https://openalex.org/W4405851012","https://openalex.org/W1967066538","https://openalex.org/W1982338880","https://openalex.org/W2093383045","https://openalex.org/W2080716292","https://openalex.org/W2082994963","https://openalex.org/W2014015124","https://openalex.org/W2038756488","https://openalex.org/W4240372104"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}