{"id":"https://openalex.org/W2031508271","doi":"https://doi.org/10.1148/radiol.2423052039","title":"High-Power Generator for Radiofrequency Ablation: Larger Electrodes and Pulsing Algorithms in Bovine ex Vivo and Porcine in Vivo Settings","display_name":"High-Power Generator for Radiofrequency Ablation: Larger Electrodes and Pulsing Algorithms in Bovine ex Vivo and Porcine in Vivo Settings","publication_year":2007,"publication_date":"2007-01-24","ids":{"openalex":"https://openalex.org/W2031508271","doi":"https://doi.org/10.1148/radiol.2423052039","mag":"2031508271","pmid":"https://pubmed.ncbi.nlm.nih.gov/17244719"},"language":"en","primary_location":{"id":"doi:10.1148/radiol.2423052039","doi":"https://doi.org/10.1148/radiol.2423052039","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.2423052039","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051816440","display_name":"Stephanie A. Solazzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie A. Solazzo","raw_affiliation_strings":["Laboratory for Minimally Invasive Tumor Therapy, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Minimally Invasive Tumor Therapy, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006305384","display_name":"Muneeb Ahmed","orcid":"https://orcid.org/0000-0003-0323-8260","observed_orcids":["https://orcid.org/0000-0003-0323-8260","https://orcid.org/0009-0005-6146-0486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muneeb Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhengjun Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengjun Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019520582","display_name":"Andrew U. Hines-Peralta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew U. Hines-Peralta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023812050","display_name":"Shraga Nahum Goldberg","orcid":"https://orcid.org/0000-0003-2940-9822","observed_orcids":["https://orcid.org/0000-0003-2940-9822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Nahum Goldberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4045,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.91647424,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"242","issue":"3","first_page":"743","last_page":"750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiofrequency-ablation","display_name":"radiofrequency ablation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tissue-coagulation","display_name":"tissue coagulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/internal-cooling","display_name":"internal cooling","score":0.5360000133514404},{"id":"https://openalex.org/keywords/liver-ablation","display_name":"liver ablation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/simplex-optimization","display_name":"simplex optimization","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ablation-time","display_name":"ablation time","score":0.5379999876022339},{"id":"https://openalex.org/keywords/bovine-liver","display_name":"bovine liver","score":0.6639999747276306},{"id":"https://openalex.org/keywords/porcine-liver","display_name":"porcine liver","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ablation-efficacy","display_name":"ablation efficacy","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8815736770629883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8524959087371826},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7412910461425781},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.5781837701797485},{"id":"https://openalex.org/C2780992000","wikidata":"https://www.wikidata.org/wiki/Q17016113","display_name":"Generator (circuit theory)","level":3,"score":0.5555480122566223},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.459995836019516},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.37525609135627747},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3579319417476654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15496715903282166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07900187373161316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.058173805475234985},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1148/radiol.2423052039","doi":"https://doi.org/10.1148/radiol.2423052039","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.2423052039","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},{"id":"pmid:17244719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17244719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1403570842","display_name":null,"funder_award_id":"R01-CA87992-01A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1656935065","display_name":"Tumor Ablation using Radiofrequency","funder_award_id":"5r01ca087992-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1963899740","https://openalex.org/W1964815101","https://openalex.org/W1965142411","https://openalex.org/W1970195707","https://openalex.org/W1980236184","https://openalex.org/W1980475891","https://openalex.org/W2004673269","https://openalex.org/W2009868384","https://openalex.org/W2011366204","https://openalex.org/W2039788044","https://openalex.org/W2040371658","https://openalex.org/W2044212199","https://openalex.org/W2044893108","https://openalex.org/W2058528116","https://openalex.org/W2065588579","https://openalex.org/W2087147214","https://openalex.org/W2117590022","https://openalex.org/W2135947578","https://openalex.org/W2141572008","https://openalex.org/W2141687439","https://openalex.org/W2153738770","https://openalex.org/W2170409695","https://openalex.org/W2170658485","https://openalex.org/W2329969946"],"related_works":["https://openalex.org/W1980755717","https://openalex.org/W2126015150","https://openalex.org/W2031939324","https://openalex.org/W2048077848","https://openalex.org/W2120579098","https://openalex.org/W2169396778","https://openalex.org/W2040371658","https://openalex.org/W3093227122","https://openalex.org/W2121091886","https://openalex.org/W2066873543"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"prospectively":[2],"maximize":[3],"the":[4,33,36,40,92,115,140,183,194,212,218,222,312,324,328,351],"extent":[5],"of":[6,35,44,201,257,311,341,353],"tissue":[7,318],"coagulation":[8,122,224,235,269,319,325,367],"by":[9,59,151,181],"using":[10,60,152,182],"a":[11,61,153,209],"high-power":[12,63,313,374],"(1000-W,":[13],"4000-mA)":[14],"radiofrequency":[15],"(RF)":[16],"generator":[17,314],"to":[18,90,95,343,358],"optimize":[19],"pulsing":[20,93,118,219,381],"algorithms.":[21],"MATERIALS":[22],"AND":[23],"METHODS:":[24],"The":[25],"institutional":[26],"animal":[27,37],"care":[28],"and":[29,70,72,103,120,139,172,186,193,214,221,245,261,279,295,337],"use":[30,34,310],"committee":[31],"approved":[32],"model":[38],"in":[39,41,54,134,136,147,158,165,250,284,300,320],"vivo":[42,56,135,167,244,278,285,294,301,321],"portion":[43],"this":[45],"study.":[46],"RF":[47,76,108,127,161,338,375],"ablations":[48,128,149],"(n":[49],"=":[50],"258)":[51],"were":[52,123,129,142,196,346],"performed":[53,130,150],"ex":[55,166,243,277,293],"bovine":[57],"livers":[58,168],"500-kHz":[62],"generator.":[64,156,330],"Through":[65],"internally":[66],"cooled":[67],"3.0-cm":[68,231],"single":[69,232],"2.5-":[71],"4.0-cm":[73,303],"cluster":[74,266],"electrodes,":[75,192,208,233,267],"energy":[77,162],"was":[78,88,163,225,252,270],"applied":[79,164],"for":[80,169,189],"12":[81],"minutes.":[82],"For":[83,205],"each":[84],"electrode,":[85],"simplex":[86],"optimization":[87],"used":[89,97],"determine":[91],"algorithms":[94],"be":[96,370],"(ie,":[98],"5-50-second":[99],"\"on\"":[100],"[energy":[101],"application]":[102],"10-50-second":[104],"\"off\"":[105],"[cooling":[106],"without":[107],"heating]":[109],"periods).":[110],"Three-dimensional":[111],"contour":[112],"maps":[113],"expressing":[114],"relationship":[116,210],"between":[117,211],"parameters":[119],"resultant":[121,223],"constructed.":[124],"Then,":[125],"31":[126],"with":[131,144,175,198,254,286,302,305,323,327,348,372,384],"optimal":[132,184,306],"settings":[133,178,188,256],"porcine":[137],"livers,":[138],"results":[141,195],"compared":[143,322,383],"those":[145,385],"obtained":[146],"control":[148],"2000-mA":[154],"commercial":[155],"Finally,":[157],"108":[159],"experiments,":[160],"6,":[170],"12,":[171],"20":[173,344],"minutes":[174,345],"maximum":[176,234,335],"current":[177,336],"(1000-4000":[179],"mA)":[180],"on":[185,213,260],"off":[187,215],"all":[190,206],"three":[191,207],"analyzed":[197],"multivariate":[199],"analysis":[200],"variance":[202],"(MANOVA).":[203],"RESULTS:":[204],"times":[216],"during":[217],"cycle":[220],"established":[226],"(P":[227,361],"<":[228,362],".01).":[229,363],"With":[230,265],"(mean,":[236,272],"5.2":[237,296],"cm":[238,247,274,281,290,297],"+/-":[239,248,275,282,291,298],"0.1":[240],"[standard":[241],"deviation]":[242],"3.6":[246],"0.2":[249],"vivo)":[251],"achieved":[253,271,326,371],"pulse":[255,307],"10-18":[258],"seconds":[259,263],"11-20":[262],"off.":[264],"greater":[268,349],"6.5":[273],"0.6":[276],"3.9":[280],"0.3":[283,292],"2.5-cm":[287],"tip;":[288],"8.3":[289],"0.8":[299],"tip)":[304],"settings.":[308],"Thus,":[309],"yielded":[315],"substantially":[316],"increased":[317,334],"standard":[329],"MANOVA":[331],"revealed":[332],"that":[333],"ablation":[339],"durations":[340],"up":[342],"associated":[347],"coagulation,":[350],"size":[352],"which":[354],"also":[355],"varied":[356],"according":[357],"electrode":[359],"type":[360],"CONCLUSION:":[364],"Markedly":[365],"larger":[366],"zones":[368],"can":[369],"optimized":[373],"ablation.":[376],"This":[377],"may":[378],"require":[379],"longer":[380],"intervals":[382],"previously":[386],"used.":[387]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}