{"id":"https://openalex.org/W2031404063","doi":"https://doi.org/10.1038/sj.onc.1210086","title":"Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells","display_name":"Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells","publication_year":2006,"publication_date":"2006-10-30","ids":{"openalex":"https://openalex.org/W2031404063","doi":"https://doi.org/10.1038/sj.onc.1210086","mag":"2031404063","pmid":"https://pubmed.ncbi.nlm.nih.gov/17072341"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1210086","doi":"https://doi.org/10.1038/sj.onc.1210086","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1210086","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010826685","display_name":"John Zeng\u2010Hong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Li","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA","Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045390774","display_name":"William H. Wood","orcid":"https://orcid.org/0000-0003-0683-8085","observed_orcids":["https://orcid.org/0000-0003-0683-8085"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W H Wood","raw_affiliation_strings":["Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052081713","display_name":"Kevin G. Becker","orcid":"https://orcid.org/0000-0002-6794-6656","observed_orcids":["https://orcid.org/0000-0002-6794-6656"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K G Becker","raw_affiliation_strings":["Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Resources Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085589424","display_name":"Ashani T. Weeraratna","orcid":"https://orcid.org/0000-0003-0448-6952","observed_orcids":["https://orcid.org/0000-0003-0448-6952"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A T Weeraratna","raw_affiliation_strings":["Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082675587","display_name":"Patrice J. Morin","orcid":"https://orcid.org/0000-0001-5488-986X","observed_orcids":["https://orcid.org/0000-0001-5488-986X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P J Morin","raw_affiliation_strings":["Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA","Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, USA","Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082675587"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210136897"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":1.5599,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.82006369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"26","issue":"20","first_page":"2860","last_page":"2872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8640000224113464},{"id":"https://openalex.org/keywords/transcriptional-response","display_name":"transcriptional response","score":0.8349999785423279},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9950000047683716},{"id":"https://openalex.org/keywords/twist1","display_name":"TWIST1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.7490000128746033},{"id":"https://openalex.org/keywords/a2780-cells","display_name":"A2780 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/p53-knockdown","display_name":"p53 knockdown","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8928228616714478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8324704766273499},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7006802558898926},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5181228518486023},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5088322758674622},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5027852058410645},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.47558915615081787},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4654335081577301},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.43759840726852417},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4345451891422272},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.42920950055122375},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4247221052646637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4199162423610687},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3508760929107666},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.20833033323287964},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.18718594312667847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1796463429927826},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12103083729743958}],"mesh":[{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018284","descriptor_name":"Cystadenocarcinoma, Serous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018284","descriptor_name":"Cystadenocarcinoma, Serous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1210086","doi":"https://doi.org/10.1038/sj.onc.1210086","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1210086","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:17072341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17072341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W45574792","https://openalex.org/W71615215","https://openalex.org/W1493803609","https://openalex.org/W1509216925","https://openalex.org/W1558366281","https://openalex.org/W1658527458","https://openalex.org/W1867229952","https://openalex.org/W1973201819","https://openalex.org/W1978678628","https://openalex.org/W1979107658","https://openalex.org/W1979319210","https://openalex.org/W1981126547","https://openalex.org/W1981797176","https://openalex.org/W1982097971","https://openalex.org/W1986025763","https://openalex.org/W1987377236","https://openalex.org/W1996474536","https://openalex.org/W2002636141","https://openalex.org/W2004150291","https://openalex.org/W2004969496","https://openalex.org/W2007208661","https://openalex.org/W2009947878","https://openalex.org/W2014966556","https://openalex.org/W2033660939","https://openalex.org/W2038437697","https://openalex.org/W2039832404","https://openalex.org/W2047003388","https://openalex.org/W2049264404","https://openalex.org/W2055169194","https://openalex.org/W2068951506","https://openalex.org/W2068991440","https://openalex.org/W2073298214","https://openalex.org/W2083841434","https://openalex.org/W2087367550","https://openalex.org/W2104398672","https://openalex.org/W2105616976","https://openalex.org/W2105631098","https://openalex.org/W2107277218","https://openalex.org/W2111237188","https://openalex.org/W2128962855","https://openalex.org/W2133734904","https://openalex.org/W2135193866","https://openalex.org/W2140956181","https://openalex.org/W2141326128","https://openalex.org/W2150289099","https://openalex.org/W2157753339","https://openalex.org/W2160516296","https://openalex.org/W2161315436","https://openalex.org/W2164277862","https://openalex.org/W2168672165","https://openalex.org/W2183609636","https://openalex.org/W2417202149","https://openalex.org/W6601907360"],"related_works":["https://openalex.org/W3045001292","https://openalex.org/W2004969496","https://openalex.org/W1809024175","https://openalex.org/W7095125308","https://openalex.org/W1515524431","https://openalex.org/W2185056898","https://openalex.org/W86527326","https://openalex.org/W1984518509","https://openalex.org/W2949650109","https://openalex.org/W2073103360"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}