{"id":"https://openalex.org/W2031346366","doi":"https://doi.org/10.1021/bc700319r","title":"Modulation of Antibody Pharmacokinetics by Chemical Polysialylation","display_name":"Modulation of Antibody Pharmacokinetics by Chemical Polysialylation","publication_year":2008,"publication_date":"2008-02-29","ids":{"openalex":"https://openalex.org/W2031346366","doi":"https://doi.org/10.1021/bc700319r","mag":"2031346366","pmid":"https://pubmed.ncbi.nlm.nih.gov/18307285"},"language":"en","primary_location":{"id":"doi:10.1021/bc700319r","doi":"https://doi.org/10.1021/bc700319r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc700319r","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045416930","display_name":"Antony Constantinou","orcid":"https://orcid.org/0009-0004-7924-7141","observed_orcids":["https://orcid.org/0009-0004-7924-7141"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antony Constantinou","raw_affiliation_strings":["Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055662549","display_name":"Agamemnon A. Epenetos","orcid":"https://orcid.org/0000-0001-9084-8125","observed_orcids":["https://orcid.org/0000-0001-9084-8125"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Agamemnon A. Epenetos","raw_affiliation_strings":["Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033212909","display_name":"Dale Hreczuk-Hirst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dale Hreczuk-Hirst","raw_affiliation_strings":["Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073264497","display_name":"Sanjay Jain","orcid":"https://orcid.org/0000-0002-9241-3114","observed_orcids":["https://orcid.org/0000-0002-9241-3114"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sanjay Jain","raw_affiliation_strings":["Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056862237","display_name":"Mahendra P. Deonarain","orcid":"https://orcid.org/0000-0002-2936-169X","observed_orcids":["https://orcid.org/0000-0002-2936-169X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mahendra P. Deonarain","raw_affiliation_strings":["Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom, Lipoxen plc, 2 Royal College Street, London NW1 0NH","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056862237"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.2559,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.87280294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"3","first_page":"643","last_page":"650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polysialylation","display_name":"polysialylation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/polysialic-acid","display_name":"polysialic acid","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antibody-pharmacokinetics","display_name":"antibody pharmacokinetics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.6769999861717224},{"id":"https://openalex.org/keywords/colominic-acid","display_name":"colominic acid","score":0.7319999933242798},{"id":"https://openalex.org/keywords/antibody-conjugates","display_name":"antibody conjugates","score":0.5260000228881836},{"id":"https://openalex.org/keywords/blood-half-life","display_name":"blood half-life","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.8140000104904175},{"id":"https://openalex.org/keywords/placental-alkaline-phosphatase","display_name":"placental alkaline phosphatase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6740000247955322},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6660000085830688},{"id":"https://openalex.org/keywords/electrophoretic-mobility","display_name":"electrophoretic mobility","score":0.7200000286102295},{"id":"https://openalex.org/keywords/immunoreactivity","display_name":"immunoreactivity","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9432958364486694},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6752281785011292},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.658055305480957},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6455496549606323},{"id":"https://openalex.org/C2778993516","wikidata":"https://www.wikidata.org/wiki/Q7226934","display_name":"Polysialic acid","level":5,"score":0.6409521698951721},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5976948142051697},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5393838882446289},{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.46887826919555664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4461362659931183},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4367121458053589},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17737174034118652},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.164621502161026},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C122871604","wikidata":"https://www.wikidata.org/wiki/Q2248886","display_name":"Neural cell adhesion molecule","level":4,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bc700319r","doi":"https://doi.org/10.1021/bc700319r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc700319r","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:18307285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18307285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1536299500","https://openalex.org/W1577603732","https://openalex.org/W1839631757","https://openalex.org/W1965889970","https://openalex.org/W1970536180","https://openalex.org/W1980535563","https://openalex.org/W1985534496","https://openalex.org/W1988275349","https://openalex.org/W1989411256","https://openalex.org/W1993114178","https://openalex.org/W1994715192","https://openalex.org/W2005503279","https://openalex.org/W2008840793","https://openalex.org/W2018241449","https://openalex.org/W2022713159","https://openalex.org/W2023929116","https://openalex.org/W2028735371","https://openalex.org/W2034421123","https://openalex.org/W2037004212","https://openalex.org/W2040724296","https://openalex.org/W2045181918","https://openalex.org/W2052230654","https://openalex.org/W2052385946","https://openalex.org/W2067631880","https://openalex.org/W2075929424","https://openalex.org/W2077603264","https://openalex.org/W2092818651","https://openalex.org/W2107170234","https://openalex.org/W2112687126","https://openalex.org/W2117850825","https://openalex.org/W2124409897","https://openalex.org/W2134758761","https://openalex.org/W2137592803","https://openalex.org/W2139296689","https://openalex.org/W2150552945","https://openalex.org/W2156113162"],"related_works":["https://openalex.org/W2033648590","https://openalex.org/W2050349885","https://openalex.org/W1970375274","https://openalex.org/W2066736414","https://openalex.org/W1645869234","https://openalex.org/W1976354760","https://openalex.org/W2041760089","https://openalex.org/W7096755261","https://openalex.org/W7051861500","https://openalex.org/W1511424309"],"abstract_inverted_index":{"Chemical":[0],"coupling":[1,128],"of":[2,5,16,45,88,91,107,139,221],"a":[3,14,35,85,145,172,185,193,200,216,222],"variety":[4],"polymers":[6,66],"to":[7,28,41,64,73,119,134,208],"therapeutic":[8],"proteins":[9,92],"has":[10,58],"been":[11,26,59],"studied":[12],"as":[13,61,68],"way":[15],"improving":[17],"their":[18,82],"pharmacokinetics":[19],"and":[20,34,77,81,104,111,130,191],"pharmacodynamics":[21],"in":[22,167,171,188,203],"vivo.":[23],"Conjugates":[24],"have":[25,144],"shown":[27],"possess":[29],"greater":[30],"stability,":[31],"lower":[32,75],"immunogenicity,":[33],"longer":[36,112],"blood":[37,164,189,217],"circulation":[38],"time":[39],"due":[40,72],"the":[42,89,120,136,140,149,153,209],"chemicophysical":[43],"properties":[44],"these":[46],"hydrophilic":[47],"long":[48],"chain":[49,115],"molecules.":[50],"Naturally":[51],"occurring":[52],"colominic":[53,116],"acid":[54,117],"(polysialic":[55],"acid,":[56],"PSA)":[57],"investigated":[60],"an":[62],"alternative":[63],"synthetic":[65],"such":[67],"poly(ethylene":[69],"glycol)":[70],"(PEG)":[71],"its":[74],"toxicity":[76],"natural":[78],"metabolism.":[79],"Antibodies":[80],"fragments":[83],"are":[84],"good":[86],"example":[87],"types":[90],"which":[93],"benefit":[94],"from":[95],"pharmacokinetic":[96],"engineering.":[97],"Here,":[98],"we":[99],"chemically":[100],"attached":[101],"differing":[102,105],"amounts":[103],"lengths":[106,131],"short":[108],"(11":[109],"kDa)":[110,114],"(22":[113],"molecules":[118],"antitumor":[121],"monoclonal":[122],"antibody":[123,150],"H17E2":[124,180],"Fab":[125,141,162],"fragment.":[126],"Different":[127],"ratios":[129],"were":[132],"seen":[133],"alter":[135],"electrophoretic":[137],"mobility":[138],"fragment":[142,163],"but":[143],"minor":[146],"effect":[147],"on":[148],"immunoreactivity":[151],"toward":[152],"placental":[154],"alkaline":[155],"phosphatase":[156],"(PLAP)":[157],"antigen.":[158],"Polysialylation":[159],"generally":[160],"increased":[161],"half-life":[165],"resulting":[166],"higher":[168,195],"tumor":[169,175,196],"uptake":[170,197],"KB":[173],"human":[174],"xenograft":[176],"mouse":[177],"model.":[178],"One":[179],"Fab-PSA":[181],"conjugate":[182,213],"had":[183,215],"over":[184,192],"5-fold":[186],"increase":[187],"exposure":[190],"3-fold":[194],"with":[198],"only":[199],"marginal":[201],"decrease":[202],"tumor/blood":[204],"selectivity":[205],"ratio":[206],"compared":[207],"unconjugated":[210],"Fab.":[211],"This":[212],"also":[214],"bioavailability":[218],"approaching":[219],"that":[220],"whole":[223],"immunoglobulin.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
