{"id":"https://openalex.org/W2031318871","doi":"https://doi.org/10.1038/cddis.2015.90","title":"GSK-3\u03b2-dependent downregulation of \u03b3-taxilin and \u03b1NAC merge to regulate ER stress responses","display_name":"GSK-3\u03b2-dependent downregulation of \u03b3-taxilin and \u03b1NAC merge to regulate ER stress responses","publication_year":2015,"publication_date":"2015-04-16","ids":{"openalex":"https://openalex.org/W2031318871","doi":"https://doi.org/10.1038/cddis.2015.90","mag":"2031318871","pmid":"https://pubmed.ncbi.nlm.nih.gov/25880086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4650556"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2015.90","doi":"https://doi.org/10.1038/cddis.2015.90","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2015.90","pdf_url":"https://www.nature.com/articles/cddis201590.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis201590.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048301762","display_name":"Yuka Hotokezaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Hotokezaka","raw_affiliation_strings":["Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006749035","display_name":"Ikuo Katayama","orcid":"https://orcid.org/0000-0002-8664-0409","observed_orcids":["https://orcid.org/0000-0002-8664-0409"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Katayama","raw_affiliation_strings":["Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067880502","display_name":"Klaus van Leyen","orcid":"https://orcid.org/0000-0003-1032-3754","observed_orcids":["https://orcid.org/0000-0003-1032-3754"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K van Leyen","raw_affiliation_strings":["Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103191617","display_name":"Takashi Nakamura","orcid":"https://orcid.org/0000-0002-1284-0520","observed_orcids":["https://orcid.org/0000-0002-1284-0520"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T Nakamura","raw_affiliation_strings":["Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103191617"],"corresponding_institution_ids":["https://openalex.org/I43777268"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.834,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.65440009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"e1719","last_page":"e1719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.843999981880188},{"id":"https://openalex.org/keywords/nascent-polypeptide-associated-complex","display_name":"nascent polypeptide-associated complex","score":0.9190000295639038},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9520000219345093},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":1.0},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7059999704360962},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8767136931419373},{"id":"https://openalex.org/C197129107","wikidata":"https://www.wikidata.org/wiki/Q1921621","display_name":"Merge (version control)","level":2,"score":0.5910735726356506},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5833776593208313},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.46366173028945923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3731570243835449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3187371492385864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24188649654388428},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.15279799699783325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1489216387271881},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08635219931602478},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/cddis.2015.90","doi":"https://doi.org/10.1038/cddis.2015.90","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2015.90","pdf_url":"https://www.nature.com/articles/cddis201590.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmid:25880086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25880086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/23993603","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993603","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004779195","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/2141","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease","raw_type":"journal article"},{"id":"pmh:oai:naosite.lb.nagasaki-u.ac.jp:10069/37339","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10069/37339","pdf_url":null,"source":{"id":"https://openalex.org/S4306400113","display_name":"Nagasaki University's Academic Output SITE (Nagasaki University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43777268","host_organization_name":"Nagasaki University","host_organization_lineage":["https://openalex.org/I43777268"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1038/cddis.2015.90","doi":"https://doi.org/10.1038/cddis.2015.90","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2015.90","pdf_url":"https://www.nature.com/articles/cddis201590.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G367263213","display_name":"Involvement of cPLA2 in apoptotic and non-apoptotic cell death","funder_award_id":"24390421","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6452579454","display_name":"dual-function stress response protein","funder_award_id":"25462921","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031318871.pdf","grobid_xml":"https://content.openalex.org/works/W2031318871.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W153866532","https://openalex.org/W1523693806","https://openalex.org/W1577397450","https://openalex.org/W1579324310","https://openalex.org/W1866197725","https://openalex.org/W1893185987","https://openalex.org/W1968937229","https://openalex.org/W1970090817","https://openalex.org/W1970369203","https://openalex.org/W1972130588","https://openalex.org/W1977258127","https://openalex.org/W1978301900","https://openalex.org/W1988330295","https://openalex.org/W1991958238","https://openalex.org/W1999603875","https://openalex.org/W1999719904","https://openalex.org/W2000608506","https://openalex.org/W2001399725","https://openalex.org/W2017151574","https://openalex.org/W2017170278","https://openalex.org/W2024846866","https://openalex.org/W2025406984","https://openalex.org/W2025518316","https://openalex.org/W2027849614","https://openalex.org/W2028279477","https://openalex.org/W2031840568","https://openalex.org/W2033363278","https://openalex.org/W2034132952","https://openalex.org/W2043583138","https://openalex.org/W2048004251","https://openalex.org/W2048030072","https://openalex.org/W2051293392","https://openalex.org/W2056549304","https://openalex.org/W2062918974","https://openalex.org/W2066538173","https://openalex.org/W2074697320","https://openalex.org/W2074911710","https://openalex.org/W2080901528","https://openalex.org/W2082429191","https://openalex.org/W2084101023","https://openalex.org/W2091604713","https://openalex.org/W2100026237","https://openalex.org/W2100948166","https://openalex.org/W2106314483","https://openalex.org/W2106958893","https://openalex.org/W2109034822","https://openalex.org/W2114360920","https://openalex.org/W2125985978","https://openalex.org/W2127848114","https://openalex.org/W2131985202","https://openalex.org/W2134361367","https://openalex.org/W2154419144","https://openalex.org/W2155884826","https://openalex.org/W2159466552","https://openalex.org/W2161002188","https://openalex.org/W2162695817","https://openalex.org/W2169388089","https://openalex.org/W4248908020"],"related_works":["https://openalex.org/W2084101023","https://openalex.org/W4246904614","https://openalex.org/W2040755325","https://openalex.org/W2153933079","https://openalex.org/W2040401878","https://openalex.org/W1480803585","https://openalex.org/W2032063579","https://openalex.org/W3164631798","https://openalex.org/W2969627376","https://openalex.org/W3043439016"],"abstract_inverted_index":{"The":[0,46],"signaling":[1,64],"pathway":[2],"leading":[3],"to":[4,54,137],"the":[5,40,61,114,134,149],"endoplasmic":[6],"reticulum":[7],"(ER)":[8],"stress":[9,63,76,141],"responses":[10,37,142],"has":[11],"not":[12],"been":[13],"fully":[14],"elucidated.":[15],"Here":[16],"we":[17],"showed":[18],"that":[19,124],"glycogen":[20],"synthase":[21],"kinase-3\u03b2":[22],"(GSK-3\u03b2)-dependent":[23],"downregulation":[24,107,126],"of":[25,48,108,116,127,151],"\u03b3-taxilin":[26,49,68,94,109,128],"and":[27,39,43,78,88,100,110,129,143],"nascent":[28],"polypeptide-associated":[29],"complex":[30],"\u03b1-subunit":[31],"(\u03b1NAC)":[32],"mediates":[33],"hypoxia-induced":[34,139],"unfolded":[35],"protein":[36],"(UPRs)":[38],"subsequent":[41],"apoptotic":[42],"autophagic":[44],"pathways.":[45,82],"degradation":[47],"or":[50,69],"\u03b1NAC":[51,70,101,111],"was":[52],"sufficient":[53],"initiate":[55],"UPRs":[56],"in":[57,90,113],"normoxic":[58],"cells.":[59],"However,":[60],"ER":[62,75,140],"pathways":[65],"initiated":[66],"by":[67],"were":[71],"distinct,":[72],"triggering":[73],"different":[74,80],"sensors":[77],"activating":[79],"downstream":[81],"Hypoxia":[83],"caused":[84],"GSK-3\u03b2-dependent":[85,125],"tau":[86,97],"hyperphosphorylation":[87,98],"cleavage":[89],"neuronal":[91],"cells,":[92],"but":[93],"ablation":[95,102],"induced":[96,103],"alone":[99],"neither":[104],"changes.":[105],"Notably,":[106],"occurs":[112],"brain":[115],"patients":[117],"with":[118],"Alzheimer's":[119],"disease.":[120],"These":[121],"results":[122],"suggest":[123],"\u03b1NAC,":[130],"which":[131],"differently":[132],"activate":[133],"UPRs,":[135],"merge":[136],"regulate":[138],"provide":[144],"a":[145],"new":[146],"insight":[147],"into":[148],"pathogenesis":[150],"neurodegenerative":[152],"diseases.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
