{"id":"https://openalex.org/W2031318656","doi":"https://doi.org/10.1126/science.1130716","title":"Tandem Riboswitch Architectures Exhibit Complex Gene Control Functions","display_name":"Tandem Riboswitch Architectures Exhibit Complex Gene Control Functions","publication_year":2006,"publication_date":"2006-10-12","ids":{"openalex":"https://openalex.org/W2031318656","doi":"https://doi.org/10.1126/science.1130716","mag":"2031318656","pmid":"https://pubmed.ncbi.nlm.nih.gov/17038623"},"language":"en","primary_location":{"id":"doi:10.1126/science.1130716","doi":"https://doi.org/10.1126/science.1130716","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1130716","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054878394","display_name":"Narasimhan Sudarsan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Narasimhan Sudarsan","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033537158","display_name":"Ming Chen Hammond","orcid":"https://orcid.org/0000-0003-2666-4764","observed_orcids":["https://orcid.org/0000-0003-2666-4764"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming C. Hammond","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040621377","display_name":"Kirsten F. Block","orcid":"https://orcid.org/0000-0003-4401-3754","observed_orcids":["https://orcid.org/0000-0003-4401-3754"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten F. Block","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005312084","display_name":"R\u00fcdiger Welz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ru\u0308diger Welz","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079232304","display_name":"Jeffrey E. Barrick","orcid":"https://orcid.org/0000-0003-0888-7358","observed_orcids":["https://orcid.org/0000-0003-0888-7358"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey E. Barrick","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109442290","display_name":"Adam Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Roth","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058375820","display_name":"Ronald R. Breaker","orcid":"https://orcid.org/0000-0002-2165-536X","observed_orcids":["https://orcid.org/0000-0002-2165-536X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald R. Breaker","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Yale University, Post Office Box 208103, New Haven, CT 06520\u20138103, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033537158","https://openalex.org/A5054878394","https://openalex.org/A5058375820"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":9.373,"has_fulltext":false,"cited_by_count":264,"citation_normalized_percentile":{"value":0.98974471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"314","issue":"5797","first_page":"300","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.8069999814033508},{"id":"https://openalex.org/keywords/coenzyme-b12","display_name":"coenzyme B12","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bacillus-clausii","display_name":"Bacillus clausii","score":0.9490000009536743},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.8859999775886536},{"id":"https://openalex.org/keywords/metabolite-sensing","display_name":"metabolite sensing","score":0.6570000052452087},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C148625055","wikidata":"https://www.wikidata.org/wiki/Q418840","display_name":"Riboswitch","level":5,"score":0.97515869140625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6246844530105591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5447574257850647},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5135385990142822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5131107568740845},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.510408341884613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49601230025291443},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.4475117027759552},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4398103356361389},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4157436490058899},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.37534528970718384},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.11208200454711914}],"mesh":[{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003038","descriptor_name":"Cobamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003038","descriptor_name":"Cobamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1130716","doi":"https://doi.org/10.1126/science.1130716","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1130716","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:17038623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17038623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1177650334","display_name":null,"funder_award_id":"GM 068819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G33749474","display_name":"Predoctoral Program in Cellular and Molecular Biology","funder_award_id":"T32GM007223","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6178556887","display_name":"Natural mRNA Genetic Switches that Bind Metabolites","funder_award_id":"R01GM068819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7572530057","display_name":null,"funder_award_id":"GM 07223-31","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1590443741","https://openalex.org/W1753084790","https://openalex.org/W1972708527","https://openalex.org/W1973541487","https://openalex.org/W1987568156","https://openalex.org/W1998709767","https://openalex.org/W1999404678","https://openalex.org/W2005675760","https://openalex.org/W2007511193","https://openalex.org/W2007909703","https://openalex.org/W2008697605","https://openalex.org/W2010231172","https://openalex.org/W2012690027","https://openalex.org/W2012879790","https://openalex.org/W2014839221","https://openalex.org/W2035955641","https://openalex.org/W2041053455","https://openalex.org/W2041230751","https://openalex.org/W2045401515","https://openalex.org/W2049105226","https://openalex.org/W2078005731","https://openalex.org/W2088196774","https://openalex.org/W2088267546","https://openalex.org/W2090900888","https://openalex.org/W2114001343","https://openalex.org/W2120200447","https://openalex.org/W2122282339","https://openalex.org/W2122749842","https://openalex.org/W2124094019","https://openalex.org/W2131538597","https://openalex.org/W2131841865","https://openalex.org/W2153461732","https://openalex.org/W2154386202","https://openalex.org/W2155326939","https://openalex.org/W6814421486"],"related_works":["https://openalex.org/W2041724323","https://openalex.org/W1968058281","https://openalex.org/W4295498033","https://openalex.org/W2111056884","https://openalex.org/W2792575173","https://openalex.org/W2069165607","https://openalex.org/W2012684630","https://openalex.org/W2122282339","https://openalex.org/W7097340028","https://openalex.org/W1992590388"],"abstract_inverted_index":{"Riboswitches":[0],"are":[1],"structured":[2],"RNAs":[3],"typically":[4],"located":[5],"in":[6],"the":[7,36,40,77],"5'":[8,37],"untranslated":[9],"regions":[10],"of":[11,39,79],"bacterial":[12],"mRNAs":[13],"that":[14,35,49,65],"bind":[15],"metabolites":[16],"and":[17,26,53,76],"control":[18,63],"gene":[19,62],"expression.":[20],"Most":[21],"riboswitches":[22,48],"sense":[23],"one":[24],"metabolite":[25],"function":[27],"as":[28,67],"simple":[29,86],"genetic":[30,95],"switches.":[31],"However,":[32],"we":[33],"found":[34],"region":[38],"Bacillus":[41],"clausii":[42],"metE":[43],"messenger":[44],"RNA":[45,87],"includes":[46],"two":[47],"respond":[50],"to":[51,92],"S-adenosylmethionine":[52],"coenzyme":[54],"B12.":[55],"This":[56],"tandem":[57,81],"arrangement":[58],"yields":[59],"a":[60,68],"composite":[61],"system":[64],"functions":[66],"two-input":[69],"Boolean":[70],"NOR":[71],"logic":[72],"gate.":[73],"These":[74],"findings":[75],"discovery":[78],"additional":[80],"riboswitch":[82],"architectures":[83],"reveal":[84],"how":[85],"elements":[88],"can":[89],"be":[90],"assembled":[91],"make":[93],"sophisticated":[94],"decisions":[96],"without":[97],"involving":[98],"protein":[99],"factors.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":18}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
