{"id":"https://openalex.org/W2031294083","doi":"https://doi.org/10.4161/cc.4.3.1530","title":"An Unusual Gene Dosage Effect of p27kip1 in a Mouse Model of Prostate Cancer","display_name":"An Unusual Gene Dosage Effect of p27kip1 in a Mouse Model of Prostate Cancer","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2031294083","doi":"https://doi.org/10.4161/cc.4.3.1530","mag":"2031294083","pmid":"https://pubmed.ncbi.nlm.nih.gov/15701964"},"language":"en","primary_location":{"id":"doi:10.4161/cc.4.3.1530","doi":"https://doi.org/10.4161/cc.4.3.1530","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.4.3.1530","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.4.3.1530?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.4.3.1530?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033587895","display_name":"Cory T. Abate-Shen","orcid":"https://orcid.org/0000-0002-5021-0570","observed_orcids":["https://orcid.org/0000-0002-5021-0570"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory Abate-Shen","raw_affiliation_strings":["679 Hoes Lane ; Piscataway , New Jersey 08854 USA;","Center for Advanced Biotechnology and Medicine ; and Departments of Medicine and","Center for Advanced Biotechnology and Medicine, Department of Medicine, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"679 Hoes Lane ; Piscataway , New Jersey 08854 USA;","institution_ids":[]},{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine ; and Departments of Medicine and","institution_ids":[]},{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, Department of Medicine, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025125161","display_name":"Michael M. Shen","orcid":"https://orcid.org/0000-0002-4042-1657","observed_orcids":["https://orcid.org/0000-0002-4042-1657"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Shen","raw_affiliation_strings":["Pediatrics ; Cancer Institute of New Jersey ; UMDNJ-Robert Wood Johnson Medical School ; 679 Hoes Lane ; Piscataway , NJ 08854 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics ; Cancer Institute of New Jersey ; UMDNJ-Robert Wood Johnson Medical School ; 679 Hoes Lane ; Piscataway , NJ 08854 USA","institution_ids":["https://openalex.org/I4390039325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4390039325"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15157274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"3","first_page":"426","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.11100000143051147,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.8360000252723694},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/prostate-carcinogenesis","display_name":"prostate carcinogenesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-cycle-inhibitors","display_name":"cell cycle inhibitors","score":0.777999997138977},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6480000019073486},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8226149082183838},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7749072313308716},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6926838159561157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6813482046127319},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6754260063171387},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6189196705818176},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6135097742080688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5254710912704468},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5096161365509033},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4668852388858795},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.4600304365158081},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20759662985801697}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.4.3.1530","doi":"https://doi.org/10.4161/cc.4.3.1530","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.4.3.1530","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.4.3.1530?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:15701964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15701964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.4.3.1530","doi":"https://doi.org/10.4161/cc.4.3.1530","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.4.3.1530","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.4.3.1530?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1378233318","display_name":"Growth Factor Signaling in Prostate Development &Cancer","funder_award_id":"R01DK060887","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1690314897","display_name":null,"funder_award_id":"CA 84294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2390683131","display_name":null,"funder_award_id":"CA76501","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2445723821","display_name":"Elucidation of cancer pathways and druggable targets using mouse models.","funder_award_id":"U01CA084294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4780552116","display_name":"Roles of Nkx3.1 in prostate development and cancer","funder_award_id":"R01CA076501","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7380143532","display_name":null,"funder_award_id":"DK60887","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031294083.pdf","grobid_xml":"https://content.openalex.org/works/W2031294083.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125941911","https://openalex.org/W1978052913","https://openalex.org/W2096586949","https://openalex.org/W1987295322","https://openalex.org/W7023717853","https://openalex.org/W1495102760","https://openalex.org/W2124662269","https://openalex.org/W4237920942","https://openalex.org/W2004768524","https://openalex.org/W1969412746"],"abstract_inverted_index":{"Expression":[0],"of":[1,13,24,28,64],"the":[2,61],"p27kip1":[3,43,54,65],"cell":[4],"cycle":[5],"inhibitor":[6],"is":[7,17,36,47],"downregulated":[8],"in":[9,42,53,67],"a":[10,25,39,73],"wide":[11],"range":[12],"carcinomas,":[14],"yet":[15],"it":[16],"rarely":[18],"inactivated":[19],"completely.":[20],"Our":[21],"recent":[22],"studies":[23],"mouse":[26],"model":[27],"prostate":[29],"carcinogenesis":[30],"have":[31],"revealed":[32],"that":[33],"cancer":[34],"progression":[35],"enhanced":[37],"by":[38,50],"two-fold":[40],"reduction":[41],"gene":[44],"dosage,":[45],"but":[46],"unexpectedly":[48],"inhibited":[49],"further":[51],"decrease":[52],"activity.":[55],"This":[56],"paradoxical":[57],"finding":[58],"may":[59],"explain":[60],"unusual":[62],"features":[63],"downregulation":[66],"human":[68],"cancer,":[69],"and":[70],"also":[71],"suggests":[72],"potential":[74],"route":[75],"for":[76],"therapeutic":[77],"intervention.":[78]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
